A biomarker group for diagnosis of coronary atherosclerosis and stable angina

Abstract

A marker group for making diagnosis to distinguish coronary arterial atherosclerosis from stable angina pectoris. The marker group comprises one or more of glutathione, β-hydroxybutyric acid, proline, fumaric acid, phenylalanine and lactic acid. When a single marker is used for making diagnosis to distinguish patients with the stable angina pectoris from patients with the coronary arterial atherosclerosis, the areas under curve (AUC) of a ROC curve are all 0.7 or larger, and the marker has a clinical diagnosis significance; when the marker is used for diagnosis in combination, with the increase of the combination number, the AUC is further increased and reaches 0.988 when 6 markers are combined, and the sensitivity and the specificity are 98.5% and 98.3% respectively under the optimum cutoff value. The metabolic marker group can be used to accurately making diagnosis to distinguish the coronary arterial atherosclerosis from the stable angina pectoris, and has high sensitivity and specificity.

Description

technical field

[0001] The invention belongs to the field of biochemistry and relates to metabolic markers for diagnosis and classification of coronary heart disease, in particular to a group of metabolic markers for diagnosing and distinguishing coronary atherosclerosis and stable angina pectoris. Background technique

[0002] Coronary heart disease, also known as ischemic heart disease, involves atherosclerosis in the arteries supplying myocardial blood, that is, coronary atherosclerotic lesions cause vascular lumen narrowing or plaque formation or even rupture and complete blockage, resulting in myocardial ischemia and hypoxia. Or necrosis leads to cardiac ischemic disease, which leads to a series of serious cardiovascular events such as clinical angina pectoris and myocardial infarction. Coronary heart disease is the main killer of human health. It has the characteristics of high incidence rate, high disability rate, high recurrence rate, high mortality rate, and many co...

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