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Use of INTS10 gene/protein in inhibiting HBV gene duplication or preventing or treating HBV associated diseases

An INTS10, 1.INTS10 technology, applied in gene therapy, peptide/protein components, antiviral agents, etc., can solve problems that need to be strengthened, and achieve accurate and reliable results, accurate results, and good specificity.

Inactive Publication Date: 2016-08-10
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, research on the prevention or treatment of liver diseases caused by HBV still needs to be strengthened

Method used

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  • Use of INTS10 gene/protein in inhibiting HBV gene duplication or preventing or treating HBV associated diseases
  • Use of INTS10 gene/protein in inhibiting HBV gene duplication or preventing or treating HBV associated diseases
  • Use of INTS10 gene/protein in inhibiting HBV gene duplication or preventing or treating HBV associated diseases

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Experimental program
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Embodiment 1

[0049] 1. Material method:

[0050] Study population:

[0051] This genome-wide association study is divided into two parts: the discovery phase and the validation phase. All study subjects were Chinese adult individuals, recruited from southern, central and northern China, including a total of 5,156 cases and 4,413 controls. The case samples were those with persistent HBV infection, and the inclusion criteria were positive serum hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (anti-HBc immunoglobulin G, IgG anti-HBc) for at least 6 months. The control samples were self-limited recoverers after HBV infection, and the inclusion criteria were serum HBsAg negative and IgG anti-HBc positive for at least 6 months. The individuals in the case-control population were not related. All patients had signed informed consent, and this study was approved by the Ethics Committee of the Institute of Radiation and Radiation Medicine.

[0052] The excavation stage include...

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Abstract

The invention discloses a use of an INTS10 gene / protein in inhibiting HBV gene duplication or preventing or treating HBV associated diseases. Therefore, target cells such as liver cells or liver cancer cells excessively express the INTS10 gene, so that the duplication of the HBV gene in the liver cells or the liver cancer cells can be effectively inhibited, and therefore, the HBV associated diseases are effectively prevented or treated.

Description

technical field [0001] The present invention relates to the use of INTS10 gene / protein in inhibiting HBV gene replication or preventing or treating HBV-related diseases. Background technique [0002] Hepatitis B virus (HBV) infection is one of the most common viral infectious diseases in the world, and there are about 250 million HBV chronic carriers worldwide. There are about 120 million HBV chronic carriers in my country, which is the endemic area of ​​HBV infection. HBV infection may cause a series of liver diseases, including chronic hepatitis B, cirrhosis, and even liver cancer. Hepatitis B patients spend as much as 100 billion RMB in medical expenses every year, and the indirect loss is estimated to be more than double the direct loss. Therefore, hepatitis B is one of the most serious infectious diseases that endanger the health of our people and cause national economic losses. Effective prevention and treatment of hepatitis B is an important goal of public health i...

Claims

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Application Information

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IPC IPC(8): A61K48/00A61K38/17C12Q1/68A61P1/16A61P31/20A61P35/00
CPCA61K38/17A61K48/005C12Q1/6886C12Q1/706C12Q2600/158
Inventor 周钢桥张红星贺福初李元丰翟芸
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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