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Pharmaceutical composition of alarelin acetate and medical application of pharmaceutical composition

A kind of technology of alarelin acetate and composition, applied in the field of biomedicine, can solve the problems such as the related report of alarelin acetate that have not been seen, and achieve the effect of outstanding substantive characteristics and improved therapeutic effect

Inactive Publication Date: 2016-08-10
高满珍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are many kinds of hepatitis prevention and treatment drugs, but there are still no effective prevention and treatment drugs for acute liver failure
[0004] So far, there has been no report on the correlation between acetrelin acetate and its pharmaceutical composition and acute liver failure

Method used

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  • Pharmaceutical composition of alarelin acetate and medical application of pharmaceutical composition
  • Pharmaceutical composition of alarelin acetate and medical application of pharmaceutical composition
  • Pharmaceutical composition of alarelin acetate and medical application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0022] Separation method: (a) Grind the dried rhizome (2kg) and extract with 80% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether (3L×3 times) 3 times), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a) The ethyl acetate extract in (a) was removed with D101 type macroporous resin, first eluted with 25% ethanol for 8 column volumes, then with 70% ethanol for 12 column volumes, collected 70% eluate, and subtracted Concentrate under pressure to get 70% ethanol elution concentrate; (c) in step (b), 70% ethanol elution concentrate is separated with normal phase silica gel, and the volume ratio is 85:1 (10 column volumes), 45:1 successively (8 column volumes), 25:1 (10 column...

Embodiment 2

[0026] Embodiment 2: pharmacological action

[0027] 1. Materials and methods

[0028] 1.1 Animals

[0029] Wistar rats, body weight 170-200g, both male and female.

[0030] 1.2 Reagents and samples

[0031] Amorelin acetate was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Galactosamine (GalN) was purchased from Chongqing Medical University, and Tang reagent was produced by Xiamen Shang Reagent Factory.

[0032] 1.3 Instruments

[0033] Automatic amino acid analyzer (Beckman company)

[0034] 1.4 Rat grouping and model preparation

[0035] The rats were randomly divided into 5 groups, 12 in each group, which were normal control group, model control group, acerelin acetate group (64 mg·kg -1 ), compound (I) group (64mg·kg -1 ), acetrolene acetate and compound (I) composition group [32mg·kg -1 Amolide Acetate+32mg·kg -1 Compound (I)]. At th...

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Abstract

The invention discloses a pharmaceutical composition of acetolide acetate and its medical application. The pharmaceutical composition of acetolide acetate provided by the invention contains acetolide acetate and a kind of The obtained natural product compound (I) with a novel structure, alanorelin acetate and compound (I) acting alone can reduce the content of serum transaminase, bilirubin and urea nitrogen in animals with liver damage, alleviate jaundice and renal dysfunction, And can reduce plasma endotoxin content; when alanorelin acetate and compound (I) act in combination, the pharmacological effect is more obvious, can be developed into the medicine for the treatment of acute liver failure, has outstanding substantive characteristics compared with the prior art and significant progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of acerelin acetate, in particular to a pharmaceutical composition of acerelin acetate and its application in acute liver failure. Background technique [0002] Alanorelin acetate is a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH), which can stimulate the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH) at the initial stage of medication, causing short-term ovarian-derived steroid hormones. Elevated; repeated medication can inhibit the release of LH and FSH from the pituitary gland, reduce the level of estradiol in the blood, and achieve the effect of drug ovariectomy. This inhibitory effect can be used to treat hormone-dependent diseases such as endometriosis. [0003] There are many kinds of hepatitis prevention and treatment drugs, but there are still no effective prevention and treatment drugs for ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D303/36C07D301/32A61K38/08A61K31/336A61P1/16
CPCC07D303/36A61K31/336A61K38/08C07D301/32
Inventor 高满珍
Owner 高满珍
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