Maintenance of bronchial patency by local delivery of cytotoxic, cytostatic, or anti-neoplastic agent
A cytotoxic, anti-tumor agent technology, applied in the field of maintaining bronchial patency by local delivery of cytotoxic agents, cytostatic agents or anti-tumor agents, can solve the problems of side effects, less than ideal, less than ideal devices and methods, etc.
Inactive Publication Date: 2016-08-17
MERCATOR MEDSYST INC
View PDF8 Cites 2 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
[0007] However, many current devices and methods may be less than ideal for safe, reliable and / or effective delivery of therapeutic agents to the bronchial wall
Drugs such as mitomycin, paclitaxel, and other antineoplastic agents have been applied to the epithelial surface of the bronchi, but retention of the applied drug may be less than ideal in at least some cases
As many of these bronchial disorders are localized in situ, disadvantages of current clinical practice paradigms, including systemic and inhaled drugs, may include overall side effects resulting from increased absorption and decreased local concentrations in the target area
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0062] By way of example, the first eight figures show needle injection catheters that can benefit from the dual modulus balloons provided by the present invention.
[0063] like Figures 1A-2B As shown, the microfabricated endoluminal catheter 10 includes an actuator 12 having an actuator body 12a and a central longitudinal axis 12b. The actuator body forms a more or less C-shaped profile with an opening or slot 12d extending substantially along its length. As discussed in more detail below, when the actuator is in the unactuated state (folded state), the microneedle 14 is positioned within the actuator body ( Figure 1B ). When the actuator is operated in the actuated state (opened state), the microneedles move out of the actuator body ( Figure 2B ).
[0064] The actuator may be capped at its proximal end 12e and distal end 12f by the leading end 16 and the tip 18 of the treatment catheter 20, respectively. Through the use of radiopaque coatings or markers, the cathete...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
Methods for maintaining patency in a bronchus of a patient are presented. A catheter is positioned within the bronchus. A target region of one or more of a bronchial wall, submucosa, media, and adventitia is punctured at or adjacent a location of a debulked bronchial carcinoma with an injection needle disposed on a distal end of the catheter. Such puncturing is achieved by expanding a balloon disposed on the distal end of the catheter. The balloon is comprised of at least two materials of different elastic modulus, which allows for a flexible but relatively non-distensible, unfolding component of the balloon as well as an elastomeric, inflatable component of the balloon. Through the injection needle, an amount of cytotoxic, cytostatic, or anti-neoplastic agent is delivered to the target region. The delivered amount is effective to limit by a therapeutically beneficial amount recurrent bronchial occlusion due to recurrence of the bronchial carcinoma.
Description
[0001] cross reference [0002] This PCT application claims the benefit of U.S. Provisional Application No. 61 / 895,779, filed October 25, 2013, which is incorporated herein by reference. Background technique [0003] The present invention generally relates to medical methods and devices. More specifically, the present invention relates to endoluminal catheters having balloons with sections of differing material moduli that, when inflated, improve the tool's abutment against luminal structures such as the walls of blood vessels or the walls of other body lumens such as the bronchi or urethra. juxtaposition. The invention further relates to methods and systems for delivering agents into or near surrounding or enveloping smooth muscle or connective tissue portions of ducts, blood vessels, or luminal organs for the prevention or treatment of disease. [0004] Of particular interest to the present invention is the treatment of bronchial diseases. The bronchi in the airway carry...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/24
CPCA61M25/003A61M25/0108A61M25/1029A61N1/0529A61M2025/0087A61M2025/0183A61M2025/1059A61M2025/1086A61L29/14A61K31/337A61M25/0084A61M25/10A61M2025/0092A61M2025/105A61P11/04A61P35/00A61P43/00
Inventor K·P·塞瓦德
Owner MERCATOR MEDSYST INC