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Application of nitraria plant or nitraria plant extract to preparation of medicine for inhibiting fatty acid synthase, healthcare products, food or daily use chemical

A technology of fatty acid synthase and extract, which is applied in the fields of medicine and biology to achieve the effect of inhibiting growth, obvious activity, and mature industrial production

Inactive Publication Date: 2016-08-31
王小艳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, so far, there has been no relevant report on the inhibitory effect of Nitraria on the activity of fatty acid synthase

Method used

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  • Application of nitraria plant or nitraria plant extract to preparation of medicine for inhibiting fatty acid synthase, healthcare products, food or daily use chemical

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 white thorn fruit powder of the present invention

[0033] Get Nitraria tangutorum Bobr. fresh fruit 35g, squeeze the juice, filter, collect the filtrate, and dry to obtain 22.05g of Nitraria tangutorum Bobr. powder I of the present invention. The total flavonoid content was determined to be 15.1%.

Embodiment 2

[0034] Embodiment 2 The preparation method of Nitraria thorn fruit extract of the present invention

[0035] 1. Take 35g of fresh fruit of Nitraria tangutorum Bobr., squeeze the juice, filter, collect the filter residue, dry, crush, and set aside;

[0036] 2. Extract the pulverized filter residue with 50% v / v ethanol aqueous solution, the ratio of solid to liquid is 1:10, the extraction temperature is 45°C, the extraction time is 45min, extract once, collect the extract, concentrate and dry to obtain the invention The thorn fruit extract II is 3.88g in total. It has been determined that the total flavonoid content is 68.7%.

Embodiment 3

[0037] Embodiment 3 The preparation method of Nitraria japonica fruit extract of the present invention

[0038] 1. Take 48g of dried fruit of Nitraria tangutorum Bobr. and crush it to obtain whole fruit powder;

[0039] 2. Extract the whole fruit powder with 70% v / v ethanol aqueous solution, the ratio of solid to liquid is 1:30, the extraction temperature is 70°C, the extraction time is 120min, extract 3 times, and collect the extract;

[0040]3. Filter the extract through two stages of microfiltration membrane and ultrafiltration membrane in sequence, the filtration temperature is 20-30°C, the filtration pressure is 1.0-6.0bar; the microfiltration membrane pore size is 0.01μm-10μm, and the microfiltration membrane filtration flow rate is 20~ 500kg / h; the ultrafiltration membrane pore size is 0.002~0.1 μm, and the ultrafiltration membrane filtration flow rate is 10~500kg / h; the ultrafiltration membrane retentate is collected and dried to obtain a total of 6.76g of Nitraria jap...

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Abstract

The invention discloses application of nitraria plant or nitraria plant extract to preparation of medicine for inhibiting fatty acid synthase, healthcare products, food or daily use chemical. The enzyme activity experimental result shows that nitraria sibirica pall powder and the extract have a remarkable inhibiting effect on fatty acid synthase. The nitraria sibirica pall extract has a higher ability to inhibit fatty acid synthase than known fatty acid synthase inhibitor quercetin.

Description

technical field [0001] The invention relates to the use of Nitraria plants or their extracts in the preparation of medicines, health care products, food or daily chemical products for inhibiting fatty acid synthase, and belongs to the fields of medicine and biology. Background technique [0002] Fatty acid synthase (FAS) is the most important enzyme in the process of fat synthesis in biological cells. Tian Weixi and others proposed that "inhibiting FAS activity is an effective method to control animal body fat level" (Tian Weixi, 1994. Regulation of Animal Body Fat Level and Fatty Acid Synthase Activity. Chemistry of Life, 14, (1): 184; Tian Weixi et al. ,1996. The relationship between body fat level and liver fatty acid synthase activity of laying hens in different growth stages. Journal of Biochemistry, 12(2):234-236; Mei Li et al.,1999.Factors influencing the levels of fatty acid synthase complex activity in fowl. Biochemistry and Molecular Biology International, 47(1):6...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K8/97A61Q19/00A61P3/04A23L33/105
CPCA61K36/185A23V2002/00A61K8/97A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2800/10A61Q19/00A23V2250/21A23V2200/332A23V2200/308
Inventor 王小艳
Owner 王小艳
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