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Nand logic gate based on gold nanocluster solid phase composite and its construction method

A technology of gold nano-clusters and composites, applied in the field of nanometers, can solve the problems of difficult integration of logic gates, poor portability, non-replacement, etc., and achieve simple and fast preparation process, diversified signal reading, and fast response speed Effect

Active Publication Date: 2018-10-23
FUJIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the logic operation systems have the following disadvantages: (1) involve complex modification or labeling process, and the cost is high; (2) they are not resettable; (3) they are poor in portability and difficult to attach to solid surfaces; (4) ) cannot handle multiple input signals at the same time and the integration between logic gates is very difficult
Although many fluorescent dyes have been reported to perform logic operations, the problems of high cost, poor photostability, prone to autoxidation, and high toxicity limit their further applications.

Method used

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  • Nand logic gate based on gold nanocluster solid phase composite and its construction method
  • Nand logic gate based on gold nanocluster solid phase composite and its construction method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of BSA / 3-MPA-gold nanocluster fluorescent material: Mix 2.5 mL bovine serum albumin with a concentration of 50 mg / mL and 2.5 mL chloroauric acid solution with a concentration of 10 mmol / L, and then add 0.25 mL concentration 1 mol / L sodium hydroxide solution and 0.25 mL 4 mol / L 3-mercaptopropionic acid solution were shaken and mixed, and reacted at 4 °C for 1 hour, and the reaction solution changed from light yellow to colorless. The reaction solution was dialyzed in 20 mmol / L pH 3 phosphate buffer for 48 hours with a dialysis bag with a molecular weight cut-off of 7000, and then dialyzed in deionized water for 12 hours to obtain a BSA / 3-MPA-gold nanocluster solution. Stored in the dark at 4 °C, it can remain relatively stable for at least two months.

Embodiment 2

[0034] Preparation of gold nanoclusters-polyelectrolyte solid-phase composite: 0.5 mL of 0.5 mol / L sodium chloride solution (containing 10 mg / mL polydiallyldimethylammonium chloride) was added to 0.5 mL of Into the gold nanocluster solution prepared in Example 1, sonicate for 15 seconds; then add 1 mL of 0.5 mol / L sodium chloride solution (containing 10 mg / mL sodium polystyrene sulfonate), sonicate for 1 minute, vortex After spinning for 30 minutes, a white colloidal dispersion was finally obtained. 25 μL of the prepared colloidal dispersion was drop-coated on a glass slide, then placed in an oven at 37 °C, and taken out after 30 minutes to obtain a gold nanocluster-polyelectrolyte solid-phase composite.

Embodiment 3

[0036] Add 10 mL of 50 mmol / L acetate buffer solution with pH=3.0 to the gold nanocluster-polyelectrolyte solid-phase composite prepared in Example 2, react at room temperature for 10 minutes, and observe at a wavelength of 302 nm by an ultraviolet lamp. The nanocluster-polyelectrolyte solid-phase composite has orange-yellow fluorescence. That is, when the input signal is (0, 0), the output signal is 1 (see figure 1 ).

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Abstract

The invention discloses a NAND logic gate based on gold nanocluster solid compound and an establishment method thereof. On the basis of the phenomenon that the fluorescence of bovine serum albumin-3-mercapto propionic acid-gold nanocluster-polyelectrolyte solid compound can be induced to be quenched by Fe2+ and H2O2 coexisting in a acetate buffer solution with pH=3.0, Fe2+ and H2O2 are used as input signals and the gold nanocluster-polyelectrolyte solid compound is used as a signal converter to establish a NAND type solid logic gate system. The logic gate system has the advantages such as simple operation (no modification or marking process), good transplantability, resettable and diversification of signal reading; the logic gate system has good application prospect in fields such as clinical diagnosis, chemical sensing and environmental monitoring.

Description

technical field [0001] The invention relates to a NAND logic gate based on a BSA / 3-MPA-gold nano cluster-polyelectrolyte solid-phase compound and a construction method thereof, belonging to the field of nanotechnology. Background technique [0002] In the past few decades, chemical Boolean logic gates have attracted extensive attention and have been applied in many fields such as clinical diagnosis, chemical sensing, and environmental monitoring. At present, different types of logic gates, such as AND, OR, IMPLICATION, NAND, NOR, and INHIBIT, can be constructed by using different materials (such as nucleic acids, enzymes, organic molecules, and nanomaterials). However, most of the logic operation systems have the following disadvantages: (1) involve complex modification or labeling process, and the cost is high; (2) they are not resettable; (3) they are poor in portability and difficult to attach to solid surfaces; (4) ) cannot process multiple input signals at the same tim...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G02F3/00
CPCG02F3/00
Inventor 陈伟邓豪华李光文吴艳玉王文俊
Owner FUJIAN MEDICAL UNIV