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Multi-stage self-control micro-fluidic chip

A microfluidic chip and chip technology, applied in fluid controllers, laboratory containers, laboratory utensils, etc., can solve problems such as inconvenient operation

Active Publication Date: 2016-09-28
HANGZHOU TINKER BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] These microfluidic chips that rely on air pumps and centrifuges have solved some problems well, but they are still not very convenient in practical applications, especially in field operations.

Method used

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  • Multi-stage self-control micro-fluidic chip
  • Multi-stage self-control micro-fluidic chip

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] like figure 1 As shown, a multi-level self-controlled microfluidic chip is made of polymethyl methacrylate, consisting of a cover layer, an intermediate layer and a bottom layer, the cover layer includes a sample inlet and a vent, and the The middle layer includes a microfluidic channel, a reaction pool 1, a reaction pool 2, and a reaction pool 3. The microfluidic channel is connected in series with all the inlets, vents, and reaction pools, and the inlets and vents are respectively located at both ends of the reaction pool. The time valve 1 is located in the microfluidic channel between the reaction pool 1 and the reaction pool 2, and the time valve 2 is located in the microfluidic channel between the reaction pool 2 and the reaction pool 3.

[0019] The reaction pool and the microfluidic channel are modified according to actual needs, and the closer to the air vent, the stronger the hydrophilicity of the surface of the chip. The modification method can be physical mo...

Embodiment 2

[0024] like figure 2 A multi-level self-controlled microfluidic chip is made of polymethyl methacrylate and consists of a cover layer, a middle layer and a bottom layer, the cover layer includes a sample inlet and a vent, and the middle The layer includes a microfluidic channel, reaction pool 1 and reaction pool 2, the microfluidic channel is connected in series with all the inlets, vents, and reaction pools, and the inlets and vents are located at both ends of the reaction pool, and the time valve 1 is located In the microfluidic channel between cell 1 and reaction cell 2.

[0025] The reaction pool and the microfluidic channel are modified according to actual needs, and the closer to the air vent, the stronger the hydrophilicity of the surface of the chip. The modification method can be physical modification or chemical modification, including metal deposition, vapor phase deposition, and hydrophilic group modification. like figure 1 As shown, the reaction cell 1 is not ...

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Abstract

The invention provides a multi-stage self-control micro-fluidic chip which consists of a cover plate layer, a middle layer and a bottom plate layer, wherein the cover plate layer comprises a sample inlet and an air vent; the middle layer comprises a micro-fluidic channel, at least two reaction tanks and at least one time valve; the micro-fluidic channel is in series connection with the sample inlet, the air vent and the reaction tanks; the connecting sequence is that the sample inlet, the reaction tanks and the air vent; and the time valve is positioned in the micro-fluidic channel between two reaction tanks. The surfaces of the reaction tanks and the surface of the micro-fluidic channel are subjected to different modifying treatment according to the needs, and the closer to the surface of a chip of the air vent, the stronger the hydrophilicity; and the time valve consists of water-soluble sugar or alcohol substances. The hydrophilicity of the surface-modified micro-fluidic channel and reaction tanks can be combined with the time valve for controlling flowing of the liquid in the micro-fluidic chip. The innovative points are that the hydrophilicity of the reaction tanks is different due to the fact that the surface of the micro-fluidic channel is modified, and the micro-fluidic channel is matched with the time valve, so that the liquid in the chip is driven without external power, and therefore, self-control is realized.

Description

technical field [0001] The invention relates to the technical field of microfluidic chips, in particular to a multi-stage self-controlled microfluidic chip. Background technique [0002] Microfluidic chip, also known as microfluidic chip laboratory, is a technology that integrates macroscopic and complex biochemical experiments into a thin slice of several square centimeters, and has broad development prospects. At present, the driving forces for the movement of liquids in microfluidic chips are usually air pressure and centrifugal force. [0003] Patent document CN 105498875 A provides a centrifugal microfluidic chip for preparing droplets. The chip is composed of a three-layer structure, and the dispersed phase and continuous phase introduced into the chip are driven by the force of the centrifuge to form droplets. [0004] Patent document CN 204514801 U discloses a disposable microfluidic chip for on-site detection of pesticide residues. When the chip is applied, a micro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/50273B01L2300/0887B01L2300/161B01L2400/0463
Inventor 叶嘉明陈秋英张一休
Owner HANGZHOU TINKER BIOTECHNOLOGY CO LTD