Preparation method of medical PLLA (poly-l-lactic acid) melt-spun fibers

A poly-L-lactic acid and melt-spinning technology, which is applied in melt-spinning, medical science, textiles and papermaking, etc., can solve unknown problems, melt-spun fibers do not have good biocompatibility, and no one prepares medical PLLA melt-spun fibers Scaffold cell performance and other issues

Inactive Publication Date: 2016-09-28
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen from these documents that these studies focus on the preparation, structure and performance of PLLA melt-spun fibers for industrial use, while there are few reports on the melt-spinning of medical PLLA, and it is unknown whether it can be melt-spun
And there are currently many studies on electrospun nanofiber scaffolds of PLLA used in the biomedical field (Kurpinski KT, Stephenson JT, Janairo RRR, et al. The effect of fiber alignment and heparin coating on cell infiltration into nanofibrous PLLA scaffolds. Biomaterials 2010;31(13):3536-42; Yang F, Murugan R, Wang S, et al. Electrospinning of nano/micro scale poly (L-lactic acid) aligned fibers and their potential in neural tissue engineering. Biomaterials 2005;26 (15):2603-10), but no one prepared medical PLLA melt-spun fibers and studied the cell properties on the fiber scaffolds
[0007] From these literatures (Nishimura Y, Takasu A, Inai Y, et al. Melt spinning of poly(L-lactic acid) and its biode

Method used

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  • Preparation method of medical PLLA (poly-l-lactic acid) melt-spun fibers
  • Preparation method of medical PLLA (poly-l-lactic acid) melt-spun fibers
  • Preparation method of medical PLLA (poly-l-lactic acid) melt-spun fibers

Examples

Experimental program
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Effect test

Embodiment 1

[0030] 1) PLLA purchased from Jinan Daigang Bioengineering Co., Ltd. has a molecular weight of 300,000 and a melting point of 176.90°C. The PLLA slices were dried at 60 °C for 24 h in a DHG-9240A electric blast drying oven to remove moisture.

[0031] 2) The PLLA melt-spun nascent fiber was prepared by extruding with a single-orifice screw extruder. The screw speed was controlled at 84.2 rad / min, the temperature of the left hot plate was 240 °C, the temperature of the right hot plate was 240 °C, and the pressure was 12.5 MPa.

[0032] 3) GKR103 winding machine was used to draw and wind the prepared melt-spun nascent fiber at a winding speed of 150 m / min.

[0033] The medical PLLA melt-spun fibers with a diameter of 27.95±5.81 μm, a smooth surface, a circular cross section and a melting point of 170.69°C were obtained.

[0034] The surface and cross-sectional morphology of the medical PLLA melt-spun fiber made in this example are as follows: figure 1 , 2 As shown, the fiber ...

Embodiment 2

[0036] 1) with embodiment step 1);

[0037] 2) PLLA melt-spun nascent fibers were prepared by extruding with a 36-orifice screw extruder. The hole diameter D of the 36-orifice plate was 0.3 mm, the hole length L / hole diameter D=3, the screw speed was controlled to be 88 rad / min, and the screw temperature is 230°C.

[0038] 3) The prepared melt-spun as-spun fibers were wound by a winding machine at a winding speed of 70 m / min. The medical PLLA melt-spun fibers with a diameter of 160±30 μm, a smooth surface, a circular cross section and a melting point of 170.69°C were obtained.

[0039] The surface and cross-sectional morphology of the medical PLLA melt-spun fiber made in this example are as follows: image 3 , 4 As shown, the fiber diameter is as Figure 7 shown.

Embodiment 3

[0041] 1) with embodiment step 1);

[0042] 2) PLLA melt-spun nascent fibers were prepared by extruding with a 24-orifice screw extruder. The hole diameter D of the 24-orifice plate was 0.3 mm, the hole length L / hole diameter D=3, the control screw speed was 88 rad / min, and the screw temperature is 230°C.

[0043] 3) The prepared melt-spun as-spun fibers were wound by a winding machine at a winding speed of 70 m / min. The medical PLLA melt-spun fibers with a diameter of 70.30±11.41 μm, a smooth surface, a circular cross section and a melting point of 170.69°C were obtained.

[0044] The surface and cross-sectional morphology of the medical PLLA melt-spun fiber made in this example are as follows: Figure 5 , 6 As shown, the fiber diameter is as Figure 7 As shown, the DSC curve is as Figure 8 shown.

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Abstract

The invention discloses a preparation method of medical PLLA (poly-l-lactic acid) melt-spun fibers. The preparation method comprises steps as follows: medical PLLA with good biodegradability and biocompatibility is sliced, dried, extruded by a screw extruder with a single-orifice plate, a 36-orifice plate or a 24-orifice plate for melt spinning and drafting winding, and the medical PLLA melt-spun fibers are prepared. The medical PLLA melt-spun fibers prepared with the method has smaller fiber diameter, smooth surface, circular cross section and higher melting point. The medical PLLA melt-spun fibers have better application prospect, can be used for simulating the fiber network structure in an ECM (extracellular matrix), and can be used for preparing fiber scaffolds applied to tissue engineering as well as woven fabric and knitted fabric scaffolds applied to blood vessels, nerves, ligaments, muscle, knees, tendons, bone tissue engineering, drug release and loading and the like.

Description

technical field [0001] The invention relates to a preparation method of medical poly-L-lactic acid melt spinning fiber. Background technique [0002] A good scaffold material should mimic the physical structure and chemical composition of natural extracellular matrix (ECM) (Shin H, Jo S, Mikos AG. Biomimetic materials for tissue engineering. Biomaterials 2003;24(24):4353-64; Wei G, Ma PX. Nanostructured biomaterials for regeneration. Adv Funct Mater 2008;18(22):3568-82). Among them, ECM is a natural ordered structure, which plays a very important role in maintaining the structure and function of cells and tissues (Stevens MM. Exploring and Engineering the Cell-Surface Interface. Biophys J 2011; 100(3 ):189a). The diameter of biological fibers in ECM is tens of nanometers to micrometers, which can provide a microenvironment suitable for cell growth. This oriented fibrous structure can guide tissue morphogenesis and remodeling, and can act as a bioactive factor to regulate ...

Claims

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Application Information

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IPC IPC(8): D01D5/08D04H1/724A61L27/18A61L27/50
CPCA61L27/18A61L27/50D01D5/08D04H1/724C08L67/04
Inventor 冯建永赵磊郭丹丹杲爽朱延圆伍永康
Owner ZHEJIANG SCI-TECH UNIV
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