Application of allene compound, pharmaceutical composition containing the same and application thereof

A compound and allene technology, which can be used in drug combinations, medical preparations containing active ingredients, anti-tumor drugs, etc., to solve the problems of poor treatment effect, recurrence and drug resistance in advanced patients

Inactive Publication Date: 2016-10-12
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The technical problem to be solved by the present invention is to provide an app

Method used

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  • Application of allene compound, pharmaceutical composition containing the same and application thereof
  • Application of allene compound, pharmaceutical composition containing the same and application thereof
  • Application of allene compound, pharmaceutical composition containing the same and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] 1. Materials and Methods

[0102] 1.1. Drugs: allene (1,2-propadienyldiphenylphosphine oxide, PHPO for short), cisplatin (CDDP for short), and paclitaxel (TAXOL for short).

[0103] 1.2. Cell lines: 6 ovarian cancer cell lines HEY, HEYA8, A2780, A2780 / CDDP, SKOV3 and SKOV3ip1, and 1 normal immortalized ovarian epithelial cell line T29. The human ovarian cancer cell line SKOV3 was purchased from the American Type Culture Collection Center (ATCC), the article number is HTB-77; the rest are ovarian cancer cell lines commonly used in international scientific research, and the cell line medium is RPMI1640, containing 100 U / mL of penicillin and 100 μg of streptomycin / mL, 10% fetal bovine serum (GIBCO product, item number 141), the culture condition is 37 ℃, 5% CO 2 , Thermo cell incubator. References: 1. Liu M, Qi Z, Liu B, Ren Y, Li H, Yang G, ZhangQ. RY-2f, an isoflavone analog, overcomes cisplatin resistance to inhibitory tumorigenesis via targeting the PI3K / AKT / mTOR si...

Embodiment 2

[0126] Example 2 Other allene compounds inhibit cell proliferation experiment

[0127] In the experiment, six ovarian cancer cell lines HEY, HEY A8, A2780, A2780 / CDDP, SKOV3 and SKOV3ip1 were used for MTT experiment to detect the anti-proliferation effect of other allene compounds. After being treated with other allene compounds at different concentrations (see Table 2) for 48 hours, the cell viability was detected by MTT assay. The results showed that these allene compounds had strong growth inhibitory effects on different ovarian cancer cell lines.

[0128] IC of other allene compounds on each cell line 50 See Table 2 for the values.

[0129] Table 2. Concentration and median lethal dose (IC) of cells treated with other allene compounds 50 )

[0130]

[0131]

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PUM

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Abstract

The invention discloses application of an allene compound, a pharmaceutical composition containing the same and application thereof. The invention discloses application of an allene compound shown as general formula (I) in preparation of drugs for treatment of cancer. The invention also discloses a pharmaceutical composition containing the allene compound shown as general formula (I) and one or more other drugs treating cancer and application thereof in preparation of drugs treating cancer. The allene compound provided by the invention can well inhibit the growth of ovarian cancer cells, at the same time combined use of the allene compound with cis-platinum can reach stronger inhibitory effect on the tumor cells and better antitumor effect. (formula (I)).

Description

technical field [0001] The invention relates to an application of an allene compound, a pharmaceutical composition containing it and application. Background technique [0002] Ovarian cancer has a low incidence rate but a high mortality rate. The current standard treatment is radical surgery + platinum-based chemotherapy. Although this program is effective for most early-stage patients, most advanced-stage patients still face the problems of relapse and drug resistance. Therefore, there is an urgent need for a new drug for the treatment of ovarian cancer in this field, in order to improve the current situation of drug resistance of ovarian cancer. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide an application of allene compounds containing Its pharmaceutical composition and application. The allene compound of the present invention can well inhibit the growth of ovarian cancer tumor cells, and at the same time...

Claims

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Application Information

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IPC IPC(8): A61K31/662A61K31/665A61K31/675A61K33/24A61K31/337A61P35/00A61P15/00
CPCA61K31/337A61K31/662A61K31/665A61K31/675A61K33/24A61K2300/00
Inventor 郭浩
Owner FUDAN UNIV
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