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Joint application of EGFR (epidermal growth factor receptor) small-molecular irreversible inhibitor and T cells in antitumor therapy

A technology of small molecules and inhibitors, which is applied in the field of combination of EGFR small molecule irreversible inhibitors and T cells in anti-tumor therapy, which can solve the problems of limited therapeutic effect of cancer types

Inactive Publication Date: 2016-10-12
JIANGSU YINUOWAN CELL CLINIC CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, although these methods have achieved good clinical results, due to the huge differences between each individual and the huge heterogeneity of tumors; therefore, the existing methods have limited therapeutic effects on many cancer types new and improved forms of treatment that demonstrate clinical benefit are urgently needed

Method used

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  • Joint application of EGFR (epidermal growth factor receptor) small-molecular irreversible inhibitor and T cells in antitumor therapy
  • Joint application of EGFR (epidermal growth factor receptor) small-molecular irreversible inhibitor and T cells in antitumor therapy
  • Joint application of EGFR (epidermal growth factor receptor) small-molecular irreversible inhibitor and T cells in antitumor therapy

Examples

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Comparison scheme
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Embodiment Construction

[0044] The following examples illustrate the invention and are not intended to limit the scope of the invention in any way.

[0045] 1. Materials and methods:

[0046] (1), reagents and mice:

[0047] A431 cells, H1975 cells, N87 cells, SW620 cells, DMSO, biological grade, DMEM medium;

[0048] RPMI-1640 medium, fetal bovine serum, MTT, double antibody, trypsin and other related organic and inorganic reagents;

[0049] Six-week-old female BALB / c female mice were selected and cultured under SPF conditions, with 12 hours of light, 12 hours of darkness, and a constant temperature of 24°C; and followed the guidelines for the correct and humane use of research animals;

[0050] (two), experimental method:

[0051] Cell-level activity determination is to test the growth inhibitory ability of compounds on cancer cells; the selected cell models are human epidermal cancer cell A431 cell line, human non-small cell lung cancer cell line H1975 cell line, human gastric cancer cell line ...

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Abstract

The invention relates to joint application of epidermal growth factor receptor (EGFR) small-molecular irreversible inhibitor (E)-N-[4-[4[(3-fluorobenzyloxy)-3-chlorophenyl]amino]-7-ethoxy-quinazoline-6-yl]-3-(pyrrolidie-2-yl)acrylamide and T cells in antitumor therapy, reducing the size of tumors in an individual and inhibiting cancer cell growth or metastatic cancer development.

Description

technical field [0001] The present invention relates to small molecule irreversible inhibitors of epithelial growth factor receptor (EGFR) (E)-N-[4-[4-[(3-fluorobenzyloxy)-3-chlorophenyl]amino]-7-ethane Oxy-quinazolin-6-yl]-3-(pyrrolidin-2-yl)acrylamide combined with T cells in antitumor therapy reduces tumor size and inhibits cancer cell growth or inhibits metastasis in an individual cancer development. Background technique [0002] In recent years, cancer has become the number one killer that seriously affects human health, and the number of deaths due to cancer is as high as 2.11 million in my country every year. The drug resistance of tumor cells in the course of medication is one of the important reasons why tumors are difficult to cure; abnormal protein kinase activity is involved in many cancers; therefore, the use of kinase inhibitors has become an important treatment method. Among them, EGFR (epidermal The development of small molecule inhibitors targeting growth ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/17A61P35/00A61P35/04A61K31/517
CPCA61K35/17A61K31/517
Inventor 曾骥孟胡鹏唐振州蒙明慧陈彪
Owner JIANGSU YINUOWAN CELL CLINIC CO LTD