Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of Ulmus pumila fruit extract in preparation of neuroprotective therapy drugs

A neuroprotection and extract technology, applied in the field of medicine, can solve the problems such as no relevant reports in the research of elm coin, and achieve the effects of good market development prospect, simple and convenient preparation method, and high yield.

Active Publication Date: 2016-10-12
NANYANG NORMAL UNIV
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through a large number of literature surveys, we found that there is no relevant report on the research on neuroprotection of Yuqian

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of Ulmus pumila fruit extract in preparation of neuroprotective therapy drugs
  • Application of Ulmus pumila fruit extract in preparation of neuroprotective therapy drugs
  • Application of Ulmus pumila fruit extract in preparation of neuroprotective therapy drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A kind of elm money extract, such as figure 1 shown, prepared by the following steps:

[0027] (1) After drying at 40°C, crush Yuqian to 30 meshes, mix it with ethanol solution with a volume fraction of 80% at a volume ratio of 1:6, soak for 20 minutes, then place it in an ultrasonic extractor, and ultrasonicate at a power of 300W Extract for 20 minutes, extract twice continuously, filter and combine the filtrate after extraction, and concentrate the obtained filtrate under reduced pressure at 40°C to obtain ethanol extract;

[0028] (2) Add distilled water to the ethanol extraction extract, wherein the volume ratio of ethanol extraction extract to distilled water is 1:1, then stir evenly to obtain a dispersion, after standing for 20 hours, filter to obtain a filtrate, and then add the same volume of chloroform (filtrate: chloroform=1:1 V / V), extract 2 times to get chloroform extract layer and water layer, then use n-butanol to extract n-butanol extract and water layer...

Embodiment 2

[0033] A kind of elm money extract, such as figure 1 shown, prepared by the following steps:

[0034] (1) After drying at 45°C, yuqian was crushed to 40 meshes, mixed with ethanol solution with a volume fraction of 85% in a volume ratio of 1:7, soaked for 30 minutes, then placed in an ultrasonic extractor, and ultrasonicated at a power of 250W Extract for 30 minutes, extract continuously for 3 times, filter and combine the filtrate after extraction, and concentrate the obtained filtrate under reduced pressure at 45°C to obtain ethanol extract;

[0035] (2) Add distilled water to the ethanol extraction extract, wherein the volume ratio of ethanol extraction extract to distilled water is 1:2, then stir evenly to obtain a dispersion, after standing for 25 hours, filter to obtain a filtrate, and then add the same volume of chloroform (filtrate: chloroform=1:1 V / V), extracted 3 times to obtain the chloroform extract layer and the water layer, then adopted n-butanol to extract the ...

Embodiment 3

[0040] A kind of elm money extract, such as figure 1 shown, prepared by the following steps:

[0041] (1) After drying at 50°C, yuqian was crushed to 50 meshes, mixed with ethanol solution with a volume fraction of 83% in a volume ratio of 1:8, soaked for 40 minutes, then placed in an ultrasonic extractor, and ultrasonicated at a power of 220W Extract for 35 minutes, extract continuously for 2 times, filter and combine the filtrate after extraction, and concentrate the obtained filtrate under reduced pressure at 50°C to obtain ethanol extract;

[0042] (2) Add distilled water to the ethanol extraction extract, wherein the volume ratio of ethanol extraction extract to distilled water is 1:1, then stir evenly to obtain a dispersion, after standing for 28 hours, filter to obtain a filtrate, and then add the same volume of chloroform (filtrate: chloroform=1:1 V / V), extract 2 times to get chloroform extract layer and water layer, then use n-butanol to extract n-butanol extract and...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of Ulmus pumila fruit extract in preparation of neuroprotective therapy drugs. The prepared Ulmus pumila fruit extract has no toxic or side effects on human bodies, and has a remarkable neuroprotective effect on PC12 cell damage models respectively induced by serum deprivation and rotenone.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the use of an extract of elm money in the preparation of neuroprotective drugs. Background technique [0002] Nerve cells are the basic functional unit of the nervous system and the main functional carrier of the central nervous system. They are highly differentiated cells and have no regenerative ability. Many diseases can cause damage to nerve cells, such as poisoning, hypoxia, cerebral apoplexy, degenerative diseases, etc., which can generally be classified into three categories, namely oxidative stress damage, excitatory amino acid damage and neurodegenerative damage, and nerve cells are severely Damage is often irreversible. Nerve cell damage will be accompanied by serious consequences, such as cerebral infarction, cerebral hemorrhage, Parkinson's disease, brain atrophy, etc., which seriously endanger human health and life safety and impose a heavy burden on in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/185A61P25/00A61P25/28
CPCA61K36/185A61K2236/333A61K2236/51A61K2236/53A61K2236/55
Inventor 马勤阁魏荣锐张正辉桑志培柳文敏高丽
Owner NANYANG NORMAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com