Application of Ulmus pumila fruit extract in preparation of neuroprotective therapy drugs

A neuroprotection and extract technology, applied in the field of medicine, can solve the problems such as no relevant reports in the research of elm coin, and achieve the effects of good market development prospect, simple and convenient preparation method, and high yield.

Active Publication Date: 2016-10-12
NANYANG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Through a large number of literature surveys, we found that there

Method used

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  • Application of Ulmus pumila fruit extract in preparation of neuroprotective therapy drugs
  • Application of Ulmus pumila fruit extract in preparation of neuroprotective therapy drugs
  • Application of Ulmus pumila fruit extract in preparation of neuroprotective therapy drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A kind of elm money extract, such as figure 1 shown, prepared by the following steps:

[0027] (1) After drying at 40°C, crush Yuqian to 30 meshes, mix it with ethanol solution with a volume fraction of 80% at a volume ratio of 1:6, soak for 20 minutes, then place it in an ultrasonic extractor, and ultrasonicate at a power of 300W Extract for 20 minutes, extract twice continuously, filter and combine the filtrate after extraction, and concentrate the obtained filtrate under reduced pressure at 40°C to obtain ethanol extract;

[0028] (2) Add distilled water to the ethanol extraction extract, wherein the volume ratio of ethanol extraction extract to distilled water is 1:1, then stir evenly to obtain a dispersion, after standing for 20 hours, filter to obtain a filtrate, and then add the same volume of chloroform (filtrate: chloroform=1:1 V / V), extract 2 times to get chloroform extract layer and water layer, then use n-butanol to extract n-butanol extract and water layer...

Embodiment 2

[0033] A kind of elm money extract, such as figure 1 shown, prepared by the following steps:

[0034] (1) After drying at 45°C, yuqian was crushed to 40 meshes, mixed with ethanol solution with a volume fraction of 85% in a volume ratio of 1:7, soaked for 30 minutes, then placed in an ultrasonic extractor, and ultrasonicated at a power of 250W Extract for 30 minutes, extract continuously for 3 times, filter and combine the filtrate after extraction, and concentrate the obtained filtrate under reduced pressure at 45°C to obtain ethanol extract;

[0035] (2) Add distilled water to the ethanol extraction extract, wherein the volume ratio of ethanol extraction extract to distilled water is 1:2, then stir evenly to obtain a dispersion, after standing for 25 hours, filter to obtain a filtrate, and then add the same volume of chloroform (filtrate: chloroform=1:1 V / V), extracted 3 times to obtain the chloroform extract layer and the water layer, then adopted n-butanol to extract the ...

Embodiment 3

[0040] A kind of elm money extract, such as figure 1 shown, prepared by the following steps:

[0041] (1) After drying at 50°C, yuqian was crushed to 50 meshes, mixed with ethanol solution with a volume fraction of 83% in a volume ratio of 1:8, soaked for 40 minutes, then placed in an ultrasonic extractor, and ultrasonicated at a power of 220W Extract for 35 minutes, extract continuously for 2 times, filter and combine the filtrate after extraction, and concentrate the obtained filtrate under reduced pressure at 50°C to obtain ethanol extract;

[0042] (2) Add distilled water to the ethanol extraction extract, wherein the volume ratio of ethanol extraction extract to distilled water is 1:1, then stir evenly to obtain a dispersion, after standing for 28 hours, filter to obtain a filtrate, and then add the same volume of chloroform (filtrate: chloroform=1:1 V / V), extract 2 times to get chloroform extract layer and water layer, then use n-butanol to extract n-butanol extract and...

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Abstract

The invention discloses application of Ulmus pumila fruit extract in preparation of neuroprotective therapy drugs. The prepared Ulmus pumila fruit extract has no toxic or side effects on human bodies, and has a remarkable neuroprotective effect on PC12 cell damage models respectively induced by serum deprivation and rotenone.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the use of an extract of elm money in the preparation of neuroprotective drugs. Background technique [0002] Nerve cells are the basic functional unit of the nervous system and the main functional carrier of the central nervous system. They are highly differentiated cells and have no regenerative ability. Many diseases can cause damage to nerve cells, such as poisoning, hypoxia, cerebral apoplexy, degenerative diseases, etc., which can generally be classified into three categories, namely oxidative stress damage, excitatory amino acid damage and neurodegenerative damage, and nerve cells are severely Damage is often irreversible. Nerve cell damage will be accompanied by serious consequences, such as cerebral infarction, cerebral hemorrhage, Parkinson's disease, brain atrophy, etc., which seriously endanger human health and life safety and impose a heavy burden on in...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P25/00A61P25/28
CPCA61K36/185A61K2236/333A61K2236/51A61K2236/53A61K2236/55
Inventor 马勤阁魏荣锐张正辉桑志培柳文敏高丽
Owner NANYANG NORMAL UNIV
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