Pharmaceutical composition for reducing progressive stroke and brain injury by applying rosmarinic acid

A technology of rosmarinic acid and composition, which is applied in the field of pharmacy, can solve the problems of no neuroprotective agents, achieve significant neuroprotective effects, inhibit inflammatory reactions, and have low cost effects

Active Publication Date: 2019-04-09
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, actively seeking new drugs with multiple neuroprotective effects has always been the focus of research and development of drugs for the treatment of ischemic stroke, but so far there is no clinically proven neuroprotective agent with clear efficacy

Method used

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  • Pharmaceutical composition for reducing progressive stroke and brain injury by applying rosmarinic acid
  • Pharmaceutical composition for reducing progressive stroke and brain injury by applying rosmarinic acid
  • Pharmaceutical composition for reducing progressive stroke and brain injury by applying rosmarinic acid

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Embodiment 1

[0023] 1 Materials 1.1 Experimental animals Healthy adult ♂, 60 SPF grade SD rats, body weight (280±20) g, purchased from Shanghai Slack Experimental Animal Co., Ltd., certificate number: 2007000509960, license number: SCXK (Shanghai) From 2007 to 0005, he was raised in the SPF level animal laboratory of the Experimental Animal Center of Fujian University of Traditional Chinese Medicine. Maintain constant temperature and humidity for 24 hours, sufficient food and drinking water, simulate natural diurnal changes, give light from 6:00 to 18:00, and be in the dark state from 18:00 to 6:00 the next day, and feed adaptively for a week.

[0024]1.2 Main Reagents and Test Drugs Total RNA Extraction Kit RNeasy® Mini Kit (QIAGEN, Cat. No.: 74106), Reverse Transcription Kit RT Kit (Fermentas, Cat. No.: K1622), Fluorescent Quantitative PCR Master Mix (Applied Biosystems, Cat. No. :R11022), PCR primers were synthesized by Shanghai Jierui Biological Engineering Co., Ltd. TNF-α gene primers...

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Abstract

The invention provides a pharmaceutical composition for reducing progressive stroke and brain injury by applying rosmarinic acid and belongs to the field of pharmacy. The pharmaceutical composition isprepared from the rosmarinic acid and salidroside, wherein the mass ratio of the rosmarinic acid to the salidroside is 1 to 1. The rosmarinic acid and salidroside combined medicine provided by the invention has more remarkable function characteristics of neuroprotection, inflammatory response inhibition and the like for tMCAO rats than those of single administration and accords with an international new orientation of screening new drugs at current. The rosmarinic acid and salidroside combined medicine provided by the application is used as a novel possible neuroprotective agent and a potential neuroprotective mechanism and provides a new experimental evidence for clinical treatment and application.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a pharmaceutical composition for reducing brain damage caused by cerebral apoplexy by applying rosmarinic acid. Background technique [0002] Stroke, commonly known as cerebral apoplexy, is a sudden-onset cerebral blood circulation disorder and the most serious complication of cerebrovascular diseases. According to my country's third national cause of death survey (2012), the fatality rate of stroke ranks first, as high as 22.45%, and the disability rate is as high as 75%, which brings serious burdens to families and society. [0003] Over the past 30 years, nearly 200 stroke drugs have entered clinical trials around the world. But so far, only tissue-type fibrinolytic agent (tPA) has been approved by the US FDA for clinical application. However, due to the shortcoming that tPA can only be used for patients with cerebral thrombosis and its treatment "time window" is narrow (...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61K31/216A61P9/10
CPCA61K31/216A61K31/7032A61P9/10A61K2300/00
Inventor 魏艺聪卢伟车苏容
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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