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Spatial resolution spectrum acquisition equipment, fluorescence imaging equipment and ion mobility spectrometer

An ion mobility spectrometer, a spatially resolved technology, used in fluorescence/phosphorescence, instruments, scientific instruments, etc.

Active Publication Date: 2019-01-11
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

When using experiments to demonstrate the theory of ion mobility spectroscopy, the movement process can only be inferred from the transient migration time spectrum of ion arrival

Method used

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  • Spatial resolution spectrum acquisition equipment, fluorescence imaging equipment and ion mobility spectrometer
  • Spatial resolution spectrum acquisition equipment, fluorescence imaging equipment and ion mobility spectrometer
  • Spatial resolution spectrum acquisition equipment, fluorescence imaging equipment and ion mobility spectrometer

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[0041] (1) The diameter of the transfer tube for ion mobility spectrometry is 16 mm, and the device structure is such that the outer edge of the turntable is preferably tangent to the inner diameter and outer edge of the transfer tube. A glass disc with a radius of 10 cm was used as the receiving plate to replace the traditional detector, and the opening time of the ion gate was 300 μm. After the door is opened, the sample ions move towards the receiving plate at a substantially constant speed in the transfer tube after experiencing a period of variable acceleration. The receiving plate captures the ions that hit its surface in turn and removes the receiving plate without disturbing the ion surface. Placed in a fluorescence imaging device, the spatially resolved spectral pattern of the sample in the ion mobility spectrum was photographed in the camera.

[0042] (2) The scale is marked on the receiving plate, and the ion gate is triggered to open each time the scale moves to th...

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Abstract

A spatially resolved spectrum collection device for ion mobility spectrometers, comprising an ionization source for generating fluorescent sample ions, a transfer tube for separating sample ions, and a receiving plate arranged at the output port of the transfer tube, where the receiving plate receives During the process of fluorescent sample ions, the receiving plate and the output port of the transfer tube move relatively, so that different plate surface areas of the receiving plate sequentially capture the fluorescent sample ions arriving at the receiving plate in order of mobility, Wherein the speed of the relative movement is greater than or equal to the moving speed of the fluorescent sample ions, so that the fluorescent sample ions struck on the receiving plate are spread out. Also disclosed herein is a fluorescence developing device used in conjunction with the space-resolved spectrum acquisition device, and an ion mobility spectrometer having the space-resolution spectrum acquisition device and the fluorescence development device. The invention changes the traditional detection mode of the ion mobility spectrometer so as to improve the detection capability of the ion mobility spectrometer.

Description

technical field [0001] The present invention relates to an ion mobility spectrometer, in particular to a spatially resolved spectrum collection device for an ion mobility spectrometer, a fluorescence developing device and an ion mobility spectrometer with the above equipment. Background technique [0002] Fluorescent molecules headed by biomacromolecular proteins usually have complex structures and have biological characteristics corresponding to the spatial configuration. Ion mobility spectrometers can analyze and study the structures of such molecules through special resolution methods (mobility). Especially for some fluorescent molecules whose mass-to-charge ratio is close or arranged in the same spatial configuration with large differences. [0003] At present, the detection of sample ion mobility usually uses the two-dimensional curve of ion current on the detector versus drift time to obtain its time-step resolution spectrum. The time ladder is easy to understand and ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/62G01N21/64G01N27/622
CPCG01N21/6428G01N27/622G01N2201/06113
Inventor 王晓浩倪凯郭开泰唐彬超史渊余泉钱翔
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV