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Applications of cannabidiol in preparing medicines for treating gouty arthritis

A technology for gouty arthritis and cannabidiol is applied in the application field of cannabidiol in the preparation of medicines for the treatment of gouty arthritis, which can solve the problems of bone marrow suppression, large side effects, and easy occurrence of gastrointestinal symptoms, and achieve relief Symptoms, rich sources, and the effect of preventing and treating hyperuricemia

Inactive Publication Date: 2016-11-09
云南瑞酚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, colchicine, a specific drug for the clinical treatment of acute gouty arthritis, has relatively large side effects, and is prone to adverse reactions such as gastrointestinal symptoms and bone marrow suppression. Therefore, it is urgent to develop a drug with specific effects and relatively small side effects

Method used

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  • Applications of cannabidiol in preparing medicines for treating gouty arthritis
  • Applications of cannabidiol in preparing medicines for treating gouty arthritis
  • Applications of cannabidiol in preparing medicines for treating gouty arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take cannabis flowers and leaves, after impurity removal, drying, and crushing, CO2 super-extraction, ethanol redissolution after impurity removal, chromatographic separation of the solution and pentane elution, collect the eluate, concentrate under reduced pressure, vacuum Dried and pulverized to obtain cannabidiol.

[0034] Get 100 grams of cannabidiol (through 80 mesh sieve), add 60 grams of microcrystalline cellulose, pass through 80 mesh sieve three times, mix well, spray 95% ethanol solution, make soft material, pass through 40 mesh sieve to granulate, 60 ℃ for half an hour, packed in 3# capsules, aluminum-plastic composite packaging, made into capsules.

Embodiment 2

[0036] Take the mixture of cannabis flowers, leaves, and hemp bran, remove impurities, dry, and pulverize, then extract with CO2, and dissolve in ethanol after removing impurities. The solution is separated by chromatography and eluted with pentane, and the eluate is collected. Concentrate under reduced pressure, dry in vacuum, and pulverize to obtain cannabidiol.

[0037] Take cannabidiol powder, add 5-20% of dry starch and 1-5% of magnesium stearate, mix, granulate, dry and compress to form tablets.

Embodiment 3

[0039] Repeat Example 2, with the following differences: get the cannabidiol powder, add sucrose water and a conventional amount of preservatives, stabilizers and other auxiliary materials. Filter, sterilize, and divide into 10mL bottles to make oral liquid.

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Abstract

The invention discloses applications of cannabidiol in preparing medicines for treating gouty arthritis. For the first time, the inventor finds that cannabidiol has the effect of obviously reducing creatinine and uric acid in serum of mice suffering from hyperuricemia, so that the hyperuricemia can be prevented and treated; meanwhile, cannabidiol can regulate the cell factors of the body, effectively resist inflammation, and alleviate gouty arthritis symptoms, and has treatment and prevention effects for the gouty arthritis. The invention further provides medicinal preparations of cannabidiol for treating gouty arthritis and corresponding medicinal dosage forms of the medicinal preparations, the medicines with different dosage forms used clinically can be prepared with a conventional preparation method, and the use is convenient.

Description

technical field [0001] The present invention relates to the new application of cannabis extract cannabidiol in medicine, in particular to the application of cannabidiol in the preparation of medicine for treating gouty arthritis. Background technique [0002] Gouty arthritis is a class of diseases caused by purine metabolism disorders in the body. Purine undergoes a series of metabolic changes, and the final product is called uric acid. Uric acid has no physiological function in the human body. Under normal circumstances, 2 / 3 of the uric acid produced in the body is excreted by the kidneys, and 1 / 3 is excreted by the large intestine. Uric acid in the body is constantly produced and excreted, so it maintains a certain concentration in the blood. In the process of purine synthesis and decomposition, various enzymes are involved. Due to the disorder of congenital abnormal metabolism of enzymes, the synthesis of uric acid is increased or the excretion is decreased, which can c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61P19/06A61P19/02
CPCA61K31/05
Inventor 陈天睿胡瀞月
Owner 云南瑞酚生物科技有限公司
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