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Application of indole-3-carbinol, diindolylmethane and derivatives of indole-3-carbinol and diindolylmethane in preparation of medicine for treating keratosis pilaris

A technology of diindolylmethane and diindolylethane is applied in the application field of preparing medicines for the treatment of keratosis pilaris, can solve problems such as affecting the appearance of skin of patients with keratosis pilaris, achieves inhibition of cancer cell growth, formula simple effect

Inactive Publication Date: 2016-11-09
张阳康
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no definite treatment for keratosis pilaris so far. Although keratosis pilaris is not a serious problem, it greatly affects the skin appearance of patients with keratosis pilaris

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The invention provides a technical scheme for the application of indole-3-carbinol, diindolylmethane and derivatives thereof in the preparation of medicines for treating keratosis pilaris: indole-3-carbinol, diindolylmethane and derivatives thereof are used in the preparation Application of drugs in keratosis pilaris.

[0016] The ointment includes the following components by weight: 8 parts of indole-3-carbinol, 4 parts of diindolylmethane, 5 parts of 6-bromoindole-3-carbinol, 4 parts of diindolylethane, 4 parts of diindolyl 3 parts of propane, 14.5 parts of auxiliary materials, 7 parts of oil base.

[0017] The auxiliary materials include the following components by weight: 1 part of salicylic acid, 2 parts of vitamin A, 1 part of tretinoin, 0.5 parts of chamomile, 3 parts of glycerin, 2 parts of chard extract, 3 parts of cod liver oil extract, 2 parts of tomato extract .

[0018] The ointment is prepared by the following steps:

[0019] S1: Weighing and proportion...

Embodiment 2

[0024] Application of indole-3-carbinol, diindolylmethane and derivatives thereof in the preparation of medicines for treating keratosis pilaris.

[0025] The ointment includes the following components by weight: 19 parts of indole-3-carbinol, 14 parts of diindolylmethane, 13 parts of 6-bromoindole-3-carbinol, 9 parts of diindolylethane, 9 parts of propane, 34 parts of auxiliary materials, 15 parts of oil base.

[0026] The auxiliary materials include the following components by weight: 3 parts of salicylic acid, 5 parts of vitamin A, 4 parts of tretinoin, 0.8 parts of chamomile, 5 parts of glycerin, 5 parts of chard extract, 5 parts of cod liver oil extract, and 5 parts of tomato extract .

[0027] The ointment is prepared by the following steps:

[0028] S1: Weighing and proportioning, weighing and taking the required raw materials according to a certain proportion of components;

[0029] S2: Stirring of auxiliary materials, transfer salicylic acid, vitamin A, tretinoin, ...

Embodiment 3

[0033] Application of indole-3-carbinol, diindolylmethane and derivatives thereof in the preparation of medicines for treating keratosis pilaris.

[0034] The ointment includes the following components by weight: 10 parts of indole-3-carbinol, 9 parts of diindolylmethane, 7 parts of 6-bromoindole-3-carbinol, 5 parts of diindolylethane, 5 parts of diindolyl 7 parts of propane, 23.3 parts of auxiliary materials, 11 parts of oil base.

[0035] The auxiliary materials include the following components by weight: 2 parts of salicylic acid, 3 parts of vitamin A, 3 parts of tretinoin, 0.3 parts of chamomile, 4 parts of glycerin, 4 parts of chard extract, 4 parts of cod liver oil extract, and 3 parts of tomato extract .

[0036] The ointment is prepared by the following steps:

[0037] S1: Weighing and proportioning, weighing and taking the required raw materials according to a certain proportion of components;

[0038] S2: Stirring of auxiliary materials, transfer salicylic acid, v...

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Abstract

The invention relates to the technical field of biological medicine, in particular to application of indole-3-carbinol, diindolylmethane and derivatives of indole-3-carbinol and diindolylmethane in preparation of medicine for treating keratosis pilaris. An ointment is prepared from, by weight, 8-19 parts of indole-3-carbinol, 4-14 parts of diindolylmethane, 5-13 parts of 6-bromoindole-3-carbinol, 4-9 parts of diindolylethane, 3-9 parts of diindolylpropane, 14-34 parts of auxiliary materials and 7-15 parts of a grease matrix. The ointment is prepared through the following steps of 1 weighing and proportioning, 2 auxiliary material stirring, 3 auxiliary material filtering and 4 ointment preparing. Accordingly, the formula is simpler, more scientific and more reasonable, and indole-3-carbinol, diindolylmethane and the derivatives of indole-3-carbinol and diindolylmethane have the effect of inhibiting growth of cancer cells; through assistance of the auxiliary materials, the ointment achieves the effect of treating the keratosis pilaris.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of indole-3-carbinol, diindolylmethane and derivatives thereof in the preparation of medicines for treating keratosis pilaris. Background technique [0002] Keratosis pilaris, also known as perikeratosis pilaris for those without an inflammatory response, is commonly known as chicken skin disease. It is often mistaken for acne or inadequate skin hygiene and cleaning, but it is actually an autosomal hereditary disease that cannot be cured. It most often occurs on the front or outside of the arms and legs, and is often mistaken for acne, pimples, or uncleanness. Occasionally it can be seen on the buttocks, back and cheeks. The disease has fewer cases or is not obvious in early childhood, but it is high in adolescence, and then gradually reduces until it disappears with age. It is characterized by severe symptoms in winter. Keratosis pilaris has no definite tr...

Claims

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Application Information

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IPC IPC(8): A61K31/404A61K9/06A61P17/00
CPCA61K9/06A61K31/404A61K47/46
Inventor 张阳康
Owner 张阳康
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