6-APA (6-amino-penicillanic acid) and preparation method thereof

A technology of aminopenicillic acid and potassium penicillin, applied in the field of penicillin, can solve the problems of high investment, high cost, large amount of organic solvent and the like
CN106086151AInactive Publication Date: 2016-11-09FARMASINO PHARMA ANHUI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FARMASINO PHARMA ANHUI
Publication Date
2016-11-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a preparation method of 6-APA (6-amino-penicillanic acid). 6-APA is prepared from a potassium carbonate reversed-extraction liquid of benzylpenicillin potassium directly, a molecular formula of 6-APA is C8H12N2O3S, and the molecular weight is 216.26. With the adoption of the process, a crystallization step can be omitted, and crystallization yield loss is avoided; extracting and washing processes of a penicillin solvent are optimized in a technical process; with the adoption of the advanced preparation process, the preparation method is higher in yield and lower in cost.
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Description

technical field

[0001] The present invention relates to a kind of penicillin, especially a kind of 6-aminopenicillanic acid adopting advanced technology and its preparation method and application. Background technique

[0002] Amoxicillin is one of the most commonly used penicillin-like broad-spectrum β-lactam antibiotics. It is a white powder with a half-life of about 61.3 minutes. It has a bacteriolytic effect and is mainly used to treat bacterial infections caused by susceptible microorganisms. Stable under acidic conditions, the gastrointestinal absorption rate reaches 90%. Amoxicillin has a strong bactericidal effect and a strong ability to penetrate cell walls. It is one of the most widely used oral penicillins at present, and its preparations include capsules, tablets, granules, dispersible tablets and so on.

[0003] 6-aminopenicillanic acid (6-APA) is an important intermediate in the production of amoxicillin. 6-aminopenicillanic acid (6-APA) is also known as pe...

Claims

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