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Polyamide-amine dendrimer supported sodium alginate antibacterial hydrogel as well as preparation method and application thereof

A technology of sodium alginate and polyamide, applied in the field of biomedical materials and functional polymers, can solve the problems of lack of antibacterial properties, achieve good swelling and pH sensitivity, reduce the cleaning process, and simple process

Active Publication Date: 2016-11-16
深圳禾昕科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the lack of antibacterial properties of traditional sodium alginate hydrogels, the present invention adopts polyamide-

Method used

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  • Polyamide-amine dendrimer supported sodium alginate antibacterial hydrogel as well as preparation method and application thereof
  • Polyamide-amine dendrimer supported sodium alginate antibacterial hydrogel as well as preparation method and application thereof
  • Polyamide-amine dendrimer supported sodium alginate antibacterial hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A sodium alginate antibacterial hydrogel loaded with polyamide-amine dendrimers, the consumption of polyamide-amine dendrimers and sodium alginate is shown in Table 1 below, and the consumption of cross-linking agent calcium carbonate is 0.7 (calcium carbonate and sodium alginate molar ratio), the consumption of gluconolactone is 2:1 (the molar ratio of gluconolactone and calcium carbonate); the generation number of described polyamidoamine dendrimers is 2 generations.

[0027] The consumption of each raw material component in the antibacterial hydrogel of table 1

[0028]

[0029] A sodium alginate antibacterial hydrogel loaded with polyamide-amine dendrimers is prepared by the following method:

[0030] (1) Take raw materials according to the amount of each raw material in Table 1;

[0031] (2) Sodium alginate is added into water, fully stirred to make it dissolve to obtain a sodium alginate solution with a concentration of 3% by mass;

[0032] (3) dissolving the...

Embodiment 2

[0040] A sodium alginate antibacterial hydrogel loaded with polyamide-amine dendrimers is prepared by the following method:

[0041] (1) Take raw materials: sodium alginate 80%, polyamide-amine dendrimers 20%, the consumption of crosslinking agent calcium carbonate is 0.7 (calcium carbonate and sodium alginate mol ratio), the consumption of gluconolactone is 2:1 (the molar ratio of gluconolactone and calcium carbonate);

[0042] (2) Adding the set amount of sodium alginate into water respectively, fully stirring to dissolve it to obtain a sodium alginate solution with a concentration of 1% to 5% by mass;

[0043] (3) dissolving the polyamide-amine dendrimers in water, adjusting the pH value to be neutral by hydrochloric acid, and obtaining a polyamide-amine dendrimer solution;

[0044] (4) Add the polyamide-amine dendrimer solution into the sodium alginate solution, mix evenly, then add calcium carbonate powder and stir quickly, then add gluconolactone powder and stir well, let...

Embodiment 3

[0051] A sodium alginate antibacterial hydrogel loaded with polyamide-amine dendrimers is prepared by the following method:

[0052] (1) Take raw materials: sodium alginate 80%, polyamide-amine dendrimers 20%, the consumption of crosslinking agent calcium carbonate is 0.3 (calcium carbonate and sodium alginate mol ratio), the consumption of gluconolactone is 2:1 (the molar ratio of gluconolactone and calcium carbonate);

[0053] (2) Add sodium alginate of different set amounts into water respectively, stir well to make it dissolve, and obtain a sodium alginate solution with a mass percentage concentration of 3%;

[0054] (3) dissolving the polyamide-amine dendrimers in water, adjusting the pH value to be neutral by hydrochloric acid, and obtaining a polyamide-amine dendrimer solution;

[0055] (4) Add the polyamide-amine dendrimer solution into the sodium alginate solution, mix evenly, then add calcium carbonate powder and stir quickly, then add gluconolactone powder and stir...

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Abstract

The invention belongs to the technical field of functional polymer materials and particularly relates to polyamide-amine dendrimer supported sodium alginate antibacterial hydrogel as well as a preparation method and an application thereof. The hydrogel is prepared from polyamide-amine dendrimers and sodium alginate through physical crosslinking under the action of a crosslinking agent. Sodium alginate and the polyamide-amine dendrimers are taken as raw materials, and the polyamide-amine dendrimer supported sodium alginate antibacterial hydrogel is obtained through the physical crosslinking under the action of a crosslinking agent, wherein the polyamide-amine dendrimers are effectively supported through electrostatic interaction between a large quantity of amino groups of the polyamide-amine dendrimers and carboxyl groups of sodium alginate; besides, compared with chemical crosslinking, the physical crosslinking adopts a physical crosslinking agent which is nontoxic, harmless and free of environmental pollution, and a later process for clearing a chemical crosslinking agent can be omitted; the hydrogel has good antibacterial performance on Gram-negative bacteria and gram-positive bacteria and has good swelling performance and pH sensitivity.

Description

technical field [0001] The invention belongs to the technical field of functional polymers, and also belongs to the technical field of biomedical materials, and specifically relates to an antibacterial hydrogel loaded with polyamide-amine dendrimers and its preparation method and application. Background technique [0002] Hydrogel is a polymer with a three-dimensional network structure, which has good water absorption, swelling and permeability, so it is widely used in biomedical materials, food and agriculture and other fields. According to whether the hydrogel itself can respond to external stimuli, it can be divided into ordinary hydrogel and smart hydrogel. Most hydrogels are formed by chemical crosslinking, but they can also be physically crosslinked. At present, most hydrogel products in the medical field use chemical cross-linking. However, the cross-linking agent added during the chemical cross-linking process generally has toxic side effects and is difficult to rem...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/04C08L87/00C08K3/26C08K5/1545
CPCC08J3/075C08J2305/04C08J2487/00C08L5/04C08L87/00C08K2003/265C08K5/1545
Inventor 何广华李亚祝超刘良殷以华易英
Owner 深圳禾昕科技有限公司
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