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Traditional Chinese medicine suppository preparation method for treating female premature ovarian failure and suppository thereof

A technology for premature ovarian failure and suppositories, which is applied in the fields of pharmaceutical formulations, suppository delivery, and medical preparations containing active ingredients, etc. It can solve problems that are unfavorable to the disease and damage the health of patients, so as to reduce the curative effect, increase the cost, and have good feasibility Effect

Inactive Publication Date: 2016-12-07
马佳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For physical therapy, there is also a limit, and it cannot be excessive. Excessiveness is not conducive to the condition and will damage the health of the patient.

Method used

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  • Traditional Chinese medicine suppository preparation method for treating female premature ovarian failure and suppository thereof
  • Traditional Chinese medicine suppository preparation method for treating female premature ovarian failure and suppository thereof
  • Traditional Chinese medicine suppository preparation method for treating female premature ovarian failure and suppository thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] 1000g of Bletilla striata, 1000g of Angelica dahurica, and 1000g of peppermint are vaporized into crystals by distillation, then pulverized, passed through a 100-120 mesh sieve, and used as component 1 for later use; then 1000g of white peony root, 1000g of Mildew Spatholobus, 1000g of motherwort, and Fu 1000g, Comfrey 1000g, Patrinia 1000g, Ligustrum lucidum 1000g, Eclipta 1000g, Mulberry 1000g, Cuscuta 1000g, Epimedium 1000g, Paeonol 1000g, Pueraria 1000g, Sophora flavescens 1000g, Cnidium 1000g, Smilax tuckahoe 1000g, 1000g Kochia scoparia, 1000g chopped dandelion, soak them in a stainless steel bucket with a cover, add 70% ethanol solution, the mass is 0.8-1 times that of coarse particles, stir evenly, keep it moist and airtight for more than 1 hour, make Fully expand; wrap the filter plate at the bottom of the percolation cylinder with a gauze bag and spread it flat, then mix and loosen the wet and expanded drug samples, then use a stainless steel spoon to hold the ...

Embodiment 2

[0061] 1100g of Bletilla striata, 1200g of Angelica dahurica, and 1200g of peppermint are vaporized into crystals by distillation, then pulverized, passed through a 100-120 mesh sieve, and used as component 1 for later use; then 1200g of white peony root, 1200g of Mildew Spatholobus, 1200g of motherwort, and Fu 1200g, Comfrey 1200g, Patrinia 1200g, Ligustrum lucidum 1200g, Eclipta 1200g, Mulberry 1200g, Cuscuta 1200g, Epimedium 1200g, Paeonol 1200g, Pueraria 1200g, Sophora flavescens 1200g, Cnidium 1200g, Smilax tuckahoe 1200g, Kochia chinensis 1200g, dandelion 1200g, chopped, placed in ethanol and heated under reflux to extract twice, each time for 1-2 hours, combine the two extracts and let stand; combine the above two extracts, concentrate under reduced pressure The filtrate with a density of 1.38 at a density of 70°C, recover ethanol, adjust the specific gravity of the obtained filtrate to 1.60, and pass it into a spray dryer for spray drying. The compressed air pressure of...

Embodiment 3

[0077] Embodiment 3: skin allergy test result

[0078] Use the suppository of the present invention to carry out induction and excitation contact tests, and treat the test mice after 24 hours and 48 hours, and there is no phenomenon such as erythema and edema in the skin, and there is no difference with the negative control group. The results show that the suppository has close to zero skin reaction intensity, that is, no skin allergy.

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Abstract

The invention discloses a traditional Chinese medicine suppository preparation method for treating female premature ovarian failure. The traditional Chinese medicine suppository preparation method comprises the steps that (a) bletilla striata, radix angelicae and mint are taken and vaporized into crystals by adopting a distillation method, smashing and fine screening are performed to obtain a component 1 for standby application; (b) the residual raw materials are subjected to ethanol extraction and concentration to obtain a component 2; (c) after the component 1 and the component 2 are mixed, a substrate is added for blending, the suppository is prepared through sizing, and sterilization and bagging are performed. In the step (a), the medicinal raw materials bletilla striata, radix angelicae and mint are taken and vaporized by adopting a distillation method to obtain a crystal substance, then smashing is performed, 100-120-mesh screening is performed to obtain the component 1 for standby application. The effective ingredients of the medicinal raw materials are scientifically compatible, and the suppository can directly reach focus, is quick in effect, small in side effect and capable of effectively relieving the pain of patients and achieving the purpose of dispelling diseases.

Description

technical field [0001] The invention relates to a medical preparation containing components derived from plants, in particular to a traditional Chinese medicine suppository for treating women with premature ovarian failure and a preparation method thereof. Background technique [0002] Premature ovarian failure (POF) refers to the phenomenon of amenorrhea before the age of 40 caused by ovarian failure. It is characterized by primary or secondary amenorrhea accompanied by elevated blood gonadotropin levels and decreased estrogen levels, accompanied by a series of low estrogen symptoms such as hot flashes, hyperhidrosis, facial flushing, and low libido. The average natural menopausal age of women is 50-52 years old, and there are differences in the distribution of menopausal age among races and regions, but the absolute value is not much different. Coulam et al. summarized the natural amenorrhea of ​​1858 women, and the incidence of POF was 1% for those younger than 40 years ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K36/90A61K9/02A61P15/00
CPCA61K36/71A61K9/0034A61K9/02A61K36/185A61K36/232A61K36/234A61K36/28A61K36/288A61K36/296A61K36/30A61K36/39A61K36/43A61K36/486A61K36/488A61K36/489A61K36/533A61K36/534A61K36/605A61K36/638A61K36/65A61K36/8905A61K36/896A61K36/898A61K36/90A61K47/10A61K47/14A61K47/44A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 马佳
Owner 马佳
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