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Belladonna liquid extract preparation method and application

The technology of belladonna liquid extract and belladonna grass is applied in the directions of medical preparations, pharmaceutical formulations, plant raw materials, etc. containing active ingredients, and can solve the problem of high impurity content in the finished extract, affecting the efficacy of medicine, and insufficient extraction of active ingredients. and other problems, to achieve high purity, good properties, and good efficacy.

Inactive Publication Date: 2016-12-14
CHONGQING WANWUCHUNSHENG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Belladonna is often prepared into extracts or liquid extracts for medicine. The preparation process of belladonna liquid extracts is clearly recorded in the Pharmacopoeia. However, the extraction of active components of belladonna liquid extracts prepared according to the process in the Insufficient. On the one hand, the impurity content of the finished extract is high, which will affect the color, shape and efficacy of the liquid extract.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Follow the steps below to prepare belladonna liquid extract:

[0036] 1. Wash and crush 1kg of belladonna herb, and impregnate it with 85% ethanol. Among them, the amount of ethanol added is twice that of medicinal herbs, and the mixture of medicinal herbs and solvents is stirred during impregnation;

[0037] 2. After soaking for 48 hours, carry out percolation. The speed of releasing the solvent during percolation is 1ml / min, and collects 2.5 times the amount of initial eluting liquid;

[0038] 3. Continue percolation to obtain 1.5 times of continuous filtrate, and combine two batches of filtrate for primary concentration. Wherein, the primary concentration is carried out at 50°C and a pressure of -0.5Mpa;

[0039] 4. After step 3 is completed, carry out secondary concentration, the secondary concentration is carried out at 50°C and pressure -0.8Mpa;

[0040] 5. Water-sedimentation is carried out on the medicinal liquid after secondary concentration. The water-sett...

Embodiment 2

[0044] Follow the steps below to prepare belladonna liquid extract:

[0045] 1. Wash and crush 2kg of belladonna herbs, and impregnate them with 85% ethanol. Among them, the amount of ethanol added is twice that of medicinal herbs, and the mixture of medicinal herbs and solvents is stirred during impregnation;

[0046] 2. After soaking for 50 hours, carry out percolation. The speed of releasing the solvent during percolation is 6ml / min, and the first eluting liquid of 3.5 times of amount is collected;

[0047] 3. Continue percolation to obtain 2.5 times of continuous filtrate, and combine two batches of filtrate for primary concentration. Wherein, the primary concentration is carried out at 50°C and a pressure of -0.7Mpa;

[0048] 4. After step 3 is completed, carry out secondary concentration, and the secondary concentration is carried out at 50°C and a pressure of -0.95Mpa;

[0049] 5. Carry out water extraction to the medicinal liquid after secondary concentration. The ...

Embodiment 3

[0053] Follow the steps below to prepare belladonna liquid extract:

[0054] 1. Wash and crush 100kg of belladonna herbs, and impregnate them with 85% ethanol. Among them, the amount of ethanol added is twice that of medicinal herbs, and the mixture of medicinal herbs and solvents is stirred during impregnation;

[0055] 2. After soaking for 40 hours, carry out percolation. The speed of releasing solvent during percolation is 400ml / min, and collects 2.5 times the amount of the first eluting liquid;

[0056] 3. Continue percolation to obtain 1.5 times of continuous filtrate, and combine two batches of filtrate for primary concentration. Wherein, the primary concentration is carried out at 50°C and a pressure of -0.6Mpa;

[0057] 4. After step 3 is completed, carry out secondary concentration, the secondary concentration is carried out at 50°C and pressure -0.9Mpa;

[0058]5. Carry out water extraction to the medicinal liquid after secondary concentration. The water extracti...

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Abstract

The invention provides a belladonna liquid extract preparation method which is characterized by particularly including the steps: 1) pre-treating belladonna herbs and then impregnating the belladonna herbs by ethyl alcohol; 2) percolating the belladonna herbs after impregnation, and combining and concentrating percolating liquid; 3) sinking and filtering the concentrated percolating liquid; 4) concentrating filtrate in the step 3) into extract, performing alcohol precipitation and then filtering the extract; 5) preparing and filling the belladonna liquid extract. The invention further provides the belladonna liquid extract prepared by the method. Compared with the prior art, the method has the advantages that effective active components in the belladonna herbs can be more sufficiently extracted, purer extract can be obtained, and the belladonna liquid extract prepared by the method conforms to all regulations of pharmacopeia and has good characters, higher purity and better efficacy.

Description

technical field [0001] The invention relates to the field of Chinese herbal medicines, in particular to a preparation method and application of belladonna liquid extract. Background technique [0002] Belladonna, alias: wild belladonna, beauty grass, belladonna grass, Latin name: Atropa belladonnaL. Solanaceae, belladonna is a perennial herb, or it is annual due to cultivation, with strong and cylindrical roots. The lower part of the stem is single, with purple, the upper part is forked branched, and the shoots are green. It is native to Europe and introduced to China in the 1930s. Belladonna is an infinite growth type. Herbs perennial, or annual due to cultivation. Roots are erect cylindrical. Stem flat hollow cylindrical. The leaves are alternate at the lower part of the stem, with short handles, and the leaves are ovate, ovate-elliptic or elliptic. Like warm and humid climate, afraid of cold, avoid high temperature. It is cultivated in Shandong, Zhejiang and other pl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61K47/02
CPCA61K36/81A61K47/02A61K2236/333A61K2236/39A61K2236/51A61K2236/53
Inventor 刘维范秀林幸忠
Owner CHONGQING WANWUCHUNSHENG PHARMA CO LTD
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