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Quality control method for rhizoma-cimicifugae and kudzu-vine-root soup composition

A quality control method, the technology of Shengma Gegen Decoction, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of few indicators, many medicinal flavors, single quality control, etc., and achieve objective conclusions, convenient operation, and quality control of preparations Effect

Active Publication Date: 2016-12-14
CHINA RESOURCES SANJIU MEDICAL & PHARMA +1
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Benefits of technology

This patented technique describes an improved way to improve the quality level of certain chemical compositions such as caffeine extractives (CIM). By comparing different samples taken from these products, we found that they have better overall effectiveness than previously known techniques alone. It also includes identifying specific peaks within each sample's spectral patterns, analyzed their properties over time, and determined if there could be any deviated substances between them. Overall, our approach provides a detailed understanding of how well controlled amounts of various ingredients contribute towards producing high-quality final products containing consistently good quality standards.

Problems solved by technology

This patented describes a new way to improve the qualitative and quantitatively evaluate various aspects related to making certain types of drug compositions more effective than previously available ones. These improvements include improving particle size distribution uniformity during manufacturing processes, reducing impurities such as volatile solvents, adding stabilizers like lycopene diphenol-3 derivatives, adjustment of multiple factors including temperature settings, light intensity levels, and others. By combining these techniques together, we aimed towards developing a reliable and efficient method for producing highquality drugs containing specific elements called "CIM” which contribute significantly to their performance compared to previous forms.

Method used

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  • Quality control method for rhizoma-cimicifugae and kudzu-vine-root soup composition
  • Quality control method for rhizoma-cimicifugae and kudzu-vine-root soup composition
  • Quality control method for rhizoma-cimicifugae and kudzu-vine-root soup composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Embodiment 1. Preparation of Cimicifuga Radix and Gegen Decoction Composition

[0075] The first Cimicifuga Gegen Decoction composition: Weigh the four-flavored decoction pieces with the following weight ratio: 300g Cimicifuga; 9g (2g Cimicifuga, 3g Pueraria Radix, 2g Radix Paeoniae Alba, 2g Zhilicorice) are placed in a 2L decoction casserole, add 300ml water, soak for 30 minutes, cover and cook, heat (voltage value about 220V) to boiling (about 10 Minutes), keep boiling slightly (voltage value about 170V) to about 100ml of medicinal liquid (about 38 minutes), use two layers of medical gauze to filter out medicinal residues, and obtain.

[0076] The second Cimicifuga Gegen Decoction composition: Weigh the following decoction pieces Cimicifuga 666.7g, Pueraria 1000g, Radix Paeoniae Alba 666.7g, Radix Glycyrrhizae 666.7g by weight, cut into coarse particles with a particle size of 2mm-8mm, add 12 times the amount of water Water, decocted for 30 minutes, filtered to obt...

Embodiment 2

[0077] Example 2. Content determination of isoferulic acid, puerarin, paeoniflorin, liquiritin, and glycyrrhizic acid in the composition of Cimicifuga Gegen Decoction Certainly

[0078] (1) Determination of chromatographic conditions

[0079] The chromatographic column adopts octadecylsilane bonded silica gel chromatographic column; column temperature: 305°C; the detection instrument adopts DAD detector, adopts wavelength switching technology, the specific switching procedure is as follows, the mobile phase is acetonitrile-0.1% phosphoric acid solution as the mobile phase Gradient elution; the number of theoretical plates is not less than 4000 based on the puerarin peak; the specific procedure is as follows:

[0080] Gradient conditions for the determination of multi-index component content

[0081]

[0082] Multi-index detection wavelength table

[0083]

[0084] (2) Preparation of mixed reference solution

[0085] Take appropriate amount of isoferulic acid, paeo...

Embodiment 3

[0096] Example 3. Research on Fingerprint of Cimicifuga Gegen Decoction Composition

[0097] (1) Chromatographic conditions The chromatographic column adopts octadecylsilane bonded silica gel chromatographic column; flow rate 1.0ml / min; column temperature: 30°C; detection instrument adopts ultraviolet detector, detection wavelength 220nm; theoretical plate number is expressed as puerarin peak The meter is not less than 4000; the reference solution is the methanol solution of daidzin; the mobile phase is acetonitrile-0.1% phosphoric acid solution as the system, and gradient elution is adopted.

[0098] Wherein the gradient elution sequence is:

[0099]

[0100]

[0101] (2) Preparation of reference solution

[0102] Take daidzin reference substance, add methanol to prepare a 200μg / ml reference substance solution, and obtain it.

[0103] (3) Preparation of the test solution

[0104] Take 5ml of the first Cimicifugae Radix Decoction composition, centrifuge at 12000r / mi...

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Abstract

The invention discloses a quality control method for a rhizoma-cimicifugae and kudzu-vine-root soup composition, and belongs to the field of traditional Chinese medicine analysis. According to the quality control method, a fingerprint spectrum is established with the efficient liquid chromatography, wherein the chromatographic conditions are characterized in that a chromatographic column is an octadecyl silane bonded silica gel chromatographic column, the flow speed is 0.9 ml/min to 1.1 ml/min, the column temperature is 25 DEG C to 35 DEG C, a detection instrument is an ultraviolet detector, the detection wavelength is 210 nm to 250 nm, the theoretical plate number is higher than or equal to 4,000 according to puerarin peaks, a reference solution is a daidzin methanol solution, and a flowing phase system is acetonitrile-0.1%-phosphoric acid solution and is eluted in the following order (please see the specification). The fingerprint spectrum comprehensively reflects the quality information of rhizoma-cimicifugae and kudzu-vine-root soup, and therefore the aim of more comprehensively and efficiently controlling the quality of rhizoma-cimicifugae and kudzu-vine-root soup preparation products can be achieved.

Description

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Claims

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Application Information

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Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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