A device and method for making large-section and large-thickness brain tissue slices

A technology for making devices and brain tissue, applied in the field of biological histology and pathology experiments, can solve the problems of difficult and high-quality production of slices, and achieve the effect of ensuring the cutting action

Inactive Publication Date: 2019-04-30
SHANDONG UNIV QILU HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

By designing a brand-new structure, the present invention effectively solves the problem that it is difficult to produce high-quality brain tissue slices with large sections and large thicknesses such as pig brains and bovine brains.

Method used

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  • A device and method for making large-section and large-thickness brain tissue slices
  • A device and method for making large-section and large-thickness brain tissue slices
  • A device and method for making large-section and large-thickness brain tissue slices

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: A kind of production device of large section and large thickness brain tissue section, its structure is as follows Figure 1-4 shown, including:

[0042] A base 101 with a cuboid structure groove 103 , a positioning plate 301 and a stopper 5 . The upper left side of the base 101 has three threaded positioning holes 104, of which the three threaded positioning holes 104 are used to cooperate with the positioning plate 301, and the upper right side has two countersunk through holes 102, two countersunk through holes 102 is used for cooperating with stopper 5.

[0043] There are four countersunk through holes 302 on the positioning plate 301, and the small diameter of the countersunk through holes 302 is slightly larger than the outer diameter of the screw used in conjunction, so that it is convenient to adjust the left and right positions of the positioning plate 301 on the base 101 to make it close to the base 101 The left side of the right stopper 5. Am...

Embodiment 2

[0051] This example relates to the preparation of 5 mm thick porcine brain tissue slices on the puncture path of the subthalamic nucleus during deep brain stimulation surgery.

[0052]The porcine brain hemispheres are left-right symmetrical in shape and physiological structure, and the mechanical properties of the materials are the same, so each porcine brain hemisphere has a suitable puncture path. The porcine brain tissue can be cut and separated from the mid-sagittal plane by using the cutting guide groove in the middle of the positioning plate 301 .

[0053] refer to Figure 5 As shown, first place the side with a distance of 5mm from the guide groove against the left side of the stopper 5. Align the mid-sagittal plane of the pig brain with the right side of the cutting guide groove 602 of the positioning plate 301, insert the cutting knife 2 into the cutting guide groove 602, and make the right side of the cutting knife 2 close to the cutting guide groove The right side...

Embodiment 3

[0057] This embodiment relates to the preparation of 6 mm thick brain tissue slices on the coronal plane of porcine brain.

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Abstract

The invention relates to a making device and method for large-section and large-thickness brain tissue slices, and belongs to the related technical field of biological histology and pathology experiments. The device mainly comprises a base with a groove, and the groove is used for preventing interference between a knife and the base when the knife is used for cutting brain tissue; the top of the base is detachably connected with a locating plate and a stop block separately, and the height of the stop block is higher than that of the locating plate; the stop block is a cuboid, and the left side face serves as the datum plane of brain tissue to be cut, wherein the locating plate is provided with guide grooves used for guiding the knife. According to the making device, the locating plate and the stop block are detachably connected, and therefore replacing is convenient; the guide grooves comprise one chopping guide groove and four slicing guide grooves, the distances between the slicing guide grooves and the side wall of the locating plate are different, and therefore the brain tissue slices with different thicknesses can be cut. According to the making device and method for the large-section and large-thickness brain tissue slices, the problem that large-section and large-thickness brain tissue slices of pig brains, cattle brains and the like are difficult to manufacture at high quality is effectively solved.

Description

technical field [0001] The invention belongs to the technical field related to biological histology and pathology experiments, and in particular relates to a device and method for making large-section and large-thickness brain tissue slices. Background technique [0002] With the growth of age and the increase of work and life pressure, certain nuclei in the human brain become dysfunctional, leading to some mental disorders, such as depression and Parkinson's disease. In addition, brain impact incidents caused by traffic accidents and falls are not uncommon. [0003] Accurate determination of the mechanical properties of brain tissue materials is helpful for neurosurgeons to accurately understand the mechanical properties of various functional nuclei materials in brain tissue, which in turn helps neurosurgeons to diagnose and determine the degree of brain lesions and plan surgical plans , Implementation. [0004] Restricted by medical ethics and sources of materials, anima...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N1/06
CPCG01N1/06
Inventor 李学恩李新钢王东海赵鹏贾德泽李刚
Owner SHANDONG UNIV QILU HOSPITAL
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