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Calcipotriol-betamethasone composition with improved stability

A technology of betamethasone and composition, applied in the field of compositions containing calcipotriol betamethasone

Active Publication Date: 2019-11-26
JIANGSU SEMPOLL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The above-mentioned technology does not completely solve the above-mentioned problems, and there is still a large room for improvement in the stability of the calcipotriol-betamethasone compound preparation

Method used

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  • Calcipotriol-betamethasone composition with improved stability
  • Calcipotriol-betamethasone composition with improved stability
  • Calcipotriol-betamethasone composition with improved stability

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The composition is as follows:

[0037]

[0038] Description: The degree of polymerization of ethylene glycol groups in the molecular structure of caprylic capric acid macrogol glyceride is 2, and the proportion of fatty acids (distribution) in the molecular structure is: the proportion of caprylic acid is 95.4%, the proportion of capric acid is 3.0%, and the proportion of dodecanoic acid The sum of its higher fatty acids and lower fatty acids than caprylic acid is 1.6%.

Embodiment 2

[0040] The composition is as follows:

[0041]

[0042] Explanation: The degree of polymerization of ethylene glycol group in the molecular structure of caprylic capric acid macrogol glyceride is 4, and the proportion of fatty acids (distribution) in the molecular structure is: the proportion of caprylic acid is 90.6%, the proportion of capric acid is 7.6%, and the proportion of dodecanoic acid The sum of its higher fatty acids and lower fatty acids than caprylic acid is 1.8%.

Embodiment 3

[0044] The composition is as follows:

[0045]

[0046] Explanation: The degree of polymerization of ethylene glycol group in the molecular structure of caprylic capric acid macrogol glyceride is 4, and the proportion of fatty acids (distribution) in the molecular structure is: the proportion of caprylic acid is 90.6%, the proportion of capric acid is 7.6%, and the proportion of dodecanoic acid The total proportion of higher fatty acids and fatty acids lower than caprylic acid is 1.8%

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Abstract

The invention discloses a composition containing calcipotriol and betamethasone. The composition comprises a vitamin D derivative or the like (such as calcipotriol), betamethasone, vitamin E-TPGS (vitamin E polyethyleneglycol succinate), labrasol and a pharmaceutically acceptable additive, wherein the polymerization degree of the ethylene glycol group in the molecular structure of the labrasol is 2-4, and the fatty acid (composition) ratio in the molecular structure is as follows: the ratio of caprylic acid is not lower than 88%, the ratio of decanoic acid is not higher than 10%, and the sum of the ratios of dodecanoic acid and higher fatty acid and fatty acid lower than the caprylic acid is not higher than 2%. The stability of the composition is improved.

Description

technical field [0001] The invention relates to a composition containing calcipotriol betamethasone. More specifically, a calcipotriol-betamethasone-containing composition with improved stability. Background technique [0002] Calcipotriol-betamethasone ointment entered the market in 2006, mainly for the treatment of stable plaque psoriasis suitable for topical treatment, and has become the drug of choice for the treatment of this disease. [0003] During the treatment of psoriasis, combination therapy comprising two or more different pharmacologically active compounds is often required. Reported patient noncompliance with treatment orders for chronic diseases such as psoriasis presents a serious challenge to healthcare workers. As a compound preparation for the treatment of psoriasis, on the one hand, the form of external application of this composition makes the administration of calcipotriol-betamethasone ointment more convenient, and the compliance between doctors and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/593A61K47/14A61K47/22A61P17/06A61K31/573
CPCA61K31/573A61K31/593A61K47/14A61K47/22A61K2300/00
Inventor 蔡蓓蕾周越强李燕
Owner JIANGSU SEMPOLL PHARMA
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