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A combination of markers for diagnosing liver cancer and its application

A marker, liver cancer technology, applied in the field of oncology and diagnosis, can solve the problem of lack of methods

Active Publication Date: 2020-03-17
SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, currently there is a lack of suitable methods

Method used

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  • A combination of markers for diagnosing liver cancer and its application
  • A combination of markers for diagnosing liver cancer and its application
  • A combination of markers for diagnosing liver cancer and its application

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Embodiment Construction

[0061] After in-depth research, the inventors have found that sphingosine-1-phosphate and syndecan-1 are abnormally expressed in the serum of patients with liver cancer, and there is a significant correlation, which can be used as markers for liver cancer staging detection.

[0062] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. For the specific experimental method not indicated in the following examples, according to the paper Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7 / syndecan-1 / TGF- β autocrine loop. 2016. doi: 10.18632 / oncotarget.11450. The staging diagnosis of liver cancer not specifically involved in this paper will be described in detail below.

[0063] Specifically, the inventors detected 40 pairs of live...

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Abstract

The invention relates to a marker combination used for liver cancer detection grading, and an application thereof, and concretely provides a use of syndecan-1 and sphingosine-1-phosphate in the preparation of a diagnostic kit for liver cancer detection grading. Researches show that the expression levels of the syndecan-1 and the sphingosine-1-phosphate in liver cancer patient's serum are substantially higher than those in normal healthy person's serum, the expression level of the syndecan-1 in liver cancer patient's serum are positively correlated with the expression level of the sphingosine-1-phosphate in the liver cancer patient's serum, and the expression levels of the syndecan-1 and the sphingosine-1-phosphate in serums of patients in different grades are obviously different. The syndecan-1 and the sphingosine-1-phosphate combination can be used as a liver cancer grading diagnosis (especially serologic diagnosis) marker, and can be used to provide a corresponding detection method and kit for realizing the liver cancer grading detection.

Description

【Technical field】 [0001] The invention relates to the technical field of oncology and diagnosis, in particular to a marker combination for diagnosing liver cancer and its application. 【Background technique】 [0002] Heparan sulfate (heparan sulfate) proteoglycan (proteoglycan) syndecan-1, the main component of the extracellular coat (glycocalyx), is a transmembrane protein that combines heparan sulfate and chondroitin sulfate on its extracellular domain (ectodomain) (chondroitin sulfate) side chain. [0003] Sphingosine-1-phosphate (Sphingosine-1-phosphate, S1P), also known as sphingosine-1-phosphate, is carried by serum albumin or high-density lipoprotein. Under normal circumstances, the blood concentration is 0.3-0.5 µM, and it can act as a second messenger or bind to the cell surface receptor 1-phosphate sphingosine type I receptor (S1P1) to exert biological functions. [0004] Currently, studies on the synergistic relationship between syndecan-1 and sphingosine-1-phosp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/574
CPCG01N33/57438G01N33/57484G01N2800/7028
Inventor 曾烨
Owner SICHUAN UNIV