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Application of low-dose sildenafil as antitumor drug

An anti-tumor drug, the technology of sildenafil, applied in the field of medicine, can solve the problems of low curative effect, large toxic and side effects, and insignificant anti-tumor curative effect, so as to achieve the effects of controlling tumor growth and promoting tumor improvement.

Inactive Publication Date: 2017-02-15
GUANGZHOU DONGLAI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the problems of low curative effect and relatively large toxic and side effects in most antitumor drugs at home and abroad, especially the problem that the antitumor curative effect of normal dose of sildenafil is not obvious when used alone, the present invention provides a low-dose sildenafil as a The application technology of anti-tumor drugs has a good curative effect on tumor treatment, but has no obvious toxic and side effects, and has a significant advancement in tumor treatment technology

Method used

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  • Application of low-dose sildenafil as antitumor drug
  • Application of low-dose sildenafil as antitumor drug
  • Application of low-dose sildenafil as antitumor drug

Examples

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Embodiment 1

[0032] A kind of application of low-dose sildenafil as antitumor drug, the chemical name of described sildenafil is 1-[4-ethoxyl group-3-[5-(6,7-dihydro-1-methanone) Base-7-oxo-3-propyl-1H-pyrazolo[4,3d]pyrimidine)]benzenesulfonyl]-4-methylpiperazine citrate, its molecular structure is as figure 1 shown. The oral dose of the sildenafil is 2-25 mg, figure 2 is a schematic diagram of sildenafil as an antitumor dose window, and the unit is mg.

[0033] For oral administration, sildenafil citrate contains an effective dose of 10 mg, which is made into sugar-coated tablets by conventional techniques and taken to achieve anti-tumor effects.

Embodiment 2

[0035] A kind of application of low-dose sildenafil as antitumor drug, the chemical name of described sildenafil is 1-[4-ethoxyl group-3-[5-(6,7-dihydro-1-methanone) Base-7-oxo-3-propyl-1H-pyrazolo[4,3d]pyrimidine)]benzenesulfonyl]-4-methylpiperazine citrate, its molecular structure is as figure 1 shown. The oral dose of the sildenafil is 2-25 mg, figure 2 is a schematic diagram of sildenafil as an antitumor dose window, and the unit is mg.

[0036] When taken internally, sildenafil citrate contains an effective dose of 20 mg, which is made into sugar-coated tablets by conventional techniques and taken to achieve anti-tumor effects.

Embodiment 3

[0038] A kind of application of low-dose sildenafil as antitumor drug, the chemical name of described sildenafil is 1-[4-ethoxyl group-3-[5-(6,7-dihydro-1-methanone) Base-7-oxo-3-propyl-1H-pyrazolo[4,3d]pyrimidine)]benzenesulfonyl]-4-methylpiperazine citrate, its molecular structure is as figure 1 shown. The oral dose of the sildenafil is 2-25 mg, figure 2 is a schematic diagram of sildenafil as an antitumor dose window, and the unit is mg.

[0039] For oral administration, sildenafil citrate contains an effective dose of 5 mg, which is made into sugar-coated tablets by conventional techniques and taken to achieve anti-tumor effects.

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Abstract

The invention relates to the technical field of medicine and discloses an application of low-dose sildenafil as an antitumor drug. The chemical name of sildenafil is 1-[4-ethoxy-3-[5-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazol[4,3d]pyrimidin)]phenylsulfonyl]-4-methylpiperazin citrate, and the use dose of sildenafil is 2-25 mg. Sildenafil citrate with the oral dose of 2-25 mg, the injection dose of 2-10 mg or the external application dose lower than 1% by mass is applied to malignant tumor treatment, the tumor growth suppressing efficiency reaches 50% or higher, obvious toxic and side effects are not generated, and the effects of effective control of tumor growth and promotion of tumor recovery are achieved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of low-dose sildenafil as an antitumor drug. Background technique [0002] Malignant tumor, also known as cancer, can occur in most tissues and organs of the body. Its main clinical features are rapid growth, strong infiltration of tissues, transfer to other parts of the body, and the production of harmful substances that destroy normal organ tissue structures. , making the body dysfunctional and seriously threatening the life of the patient. The latest data from WHO shows that by 2020, the global cancer incidence will increase by 50%, that is, 15 million new cancer patients will be added every year. Not only that, the number of cancer deaths is also rising rapidly around the world. In 2007, a total of 7.6 million people died of cancer worldwide, and this number may increase to 13.2 million in 2030. Moreover, 20% of the world's new cancer patients are in China,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61P35/00
CPCA61K31/519A61K9/06A61P35/00A61K9/0053A61K9/0019
Inventor 刘誉
Owner GUANGZHOU DONGLAI BIOTECH CO LTD