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Multi-reflecting time-of-flight mass spectrometer with an axial pulsed converter

A time-of-flight mass spectrometry and time-of-flight technology, applied in the field of time-of-flight mass spectrometry, can solve problems such as increasing costs, and achieve the effects of improving working ratio, high isobaric abundance, and good peak shape

Active Publication Date: 2017-02-15
LECO CORPORATION
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Problems solved by technology

This may require the use of at least two pulse generators, which adds to the cost and becomes challenging when combined with a 100kHz pulse rate when utilizing codes that are frequently pulsed
Fourth, further reduction of the gyration period (required for higher resolution) by using high accelerating fields in the OA is limited by the associated increase in ion packet energy spread beyond the MR-TOF energy acceptance
[0010] Thus, there are still some practical issues related to orthogonal acceleration for MR-TOF MS

Method used

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  • Multi-reflecting time-of-flight mass spectrometer with an axial pulsed converter
  • Multi-reflecting time-of-flight mass spectrometer with an axial pulsed converter
  • Multi-reflecting time-of-flight mass spectrometer with an axial pulsed converter

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Embodiment 111

[0153] see Figure 11 , another embodiment 111 of the axial beamforming device of the present disclosure includes the following components arranged axially in sequence: an accumulating ion source (exemplified as an ion chamber 112, a reflector 113, and an extractor 114); a continuous acceleration stage 43; a spatial focusing A lens 44; a time selector 45; a beamformer 47 formed by parallel electrodes 46, 48; an energy filter 49; and a TOF analyzer 50, which may be a Re-TOF MS or MR-TOF MS. The pulse generators 45p and 46p are connected to the time selector 45 and the electrode 46, respectively. Thus, the time selector 45 is optionally embodied as an additional electrode.

[0154] Figure 11 The cumulative ion source chamber 112 of embodiment 111 includes at least one electrode 113 for soft pulse extraction of ion packets having: ΔT ≈ 1 μs; and a small energy spread of about ΔK ≈ 1 eV. Thus, the product ΔK*ΔT is close to 1 eV*μs. Embodiment 111 includes an exemplary enclose...

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Abstract

Apparatuses (41, 91, 111, 115, 121, 151) and methods (31) for time-of-flight mass spectrometry providing effective pulsed conversion of continuous ion beams into pulsed ion packets is disclosed. Bunching of energetic continuous ion beams forms ion packets, which are filtered by a subsequent isochronous energy filter (49, 79, 81-84, 110). The bunching method is particularly suitable for ion sources with relatively large spatial emittance, otherwise unable to fir the acceptance of orthogonal accelerators. The method is particularly suitable for multi-reflecting TOF MS, which accommodates small size ion packets and where the duty cycle advantage of orthogonal accelerators is minor.

Description

technical field [0001] The present disclosure relates to time-of-flight mass spectrometry and to improved pulsed ion conversion methods for single-reflection and multi-reflection time-of-flight mass spectrometers. Background technique [0002] Time-of-flight mass spectrometers (TOF MS) determine the mass-to-charge ratio (m / z) of ions by accelerating ions through the TOF MS, toward a detector, and recording measurements of the ion's travel time within the TOFMS to the detector. Some implementations utilize two TOF MSs in series (TOF / TOF). Other implementations of TOF MS may include gas chromatography (GC-TOF MS) or liquid chromatography (LC-TOF MS) to process samples prior to analysis by TOF MS. Alternatively, such implementations of GC-TOF MS and LC-TOF MS may utilize quadrupole ion traps (LC-Q-TOF and GC-Q-TOF), such as in US Patent Application 2013 / 0068942. [0003] The parameters of TOF MS depend on efficient coupling to a pulsed and continuous ion source. To form io...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/40
CPCH01J49/406H01J49/44H01J49/403H01J49/06G01N30/72H01J49/0031
Inventor A·N·维尔恩驰寇韦
Owner LECO CORPORATION
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