A kind of auxiliary hypoglycemic nanoparticle and preparation method thereof

A nanoparticle, hypoglycemic technology, applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. Enhanced hypoglycemic effect, improved stability and bioavailability

Active Publication Date: 2019-08-13
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the conventional drugs for the treatment of diabetes are mainly oral hypoglycemic drugs and long-term insulin injections, but they all have different degrees of side effects, and the application of drugs is limited, which cannot meet the needs of today's fast-paced life and the ever-improving quality of life. It is necessary to find a natural substance dosage form with long-lasting hypoglycemic effect, low toxicity, convenient administration and portability

Method used

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  • A kind of auxiliary hypoglycemic nanoparticle and preparation method thereof
  • A kind of auxiliary hypoglycemic nanoparticle and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0018] A combination of sargassum oligosaccharides and monascus orange pigment assists blood sugar-lowering nanoparticles. The main raw materials include the following in parts by weight: 200 parts of sargassum, 1 part of monascus orange pigment, 2 parts of stevia leaves, 12 parts of sargassum, 8 parts of Eucheuma, 10 parts of Gracilaria, 100 parts of edible ethanol, 20 parts of soybean oil, and 75 parts of soybean lecithin.

[0019] The preparation method includes as follows:

[0020] (1) Dried 200 g of Sargassum algae, crushed them, added 95% ethanol to the dry powder of Sargassum and refluxed them for 2 hours, and the ratio of dry powder weight to ethanol volume was 1:18g / mL. Sargassum powder: Distilled water is added to the Sargassum powder, wherein the mass ratio of Sargassum to the volume of distilled water is 1:27, extracted by water extraction at 85°C for 2 hours, after the extraction is completed, filter, and repeat the above steps twice for the filter residue Extrac...

Embodiment 2

[0026] A combination of sargassum oligosaccharides and monascus orange pigment assists blood sugar-lowering nanoparticles. The main raw materials include the following in parts by weight: 100 parts of sargassum, 0.5 parts of monascus orange pigment, 1 part of stevia leaf, 10 parts of sargassum, 7 parts of Eucheuma, 5 parts of Gracilaria, 50 parts of edible ethanol, 10 parts of soybean oil, and 60 parts of soybean lecithin.

[0027] The preparation method includes as follows:

[0028] (1) Dry 100 parts of Sargassum algae and crush them, add 95% ethanol to the dry powder of Sargassum and reflux for extraction for 1 hour, the ratio of dry powder weight to ethanol volume is 1:15g / mL, remove ethanol after reflux, and dry to obtain dry degreasing Sargassum powder; distilled water is added to the Sargassum powder, wherein the mass of Sargasso to the volume ratio of distilled water is 1:25, and the water extraction method is used to extract for 2 hours at 85°C. After the extraction is...

Embodiment 3

[0034]A combination of sargassum oligosaccharides and monascus orange pigment assists blood sugar-lowering nanoparticles. The main raw materials include the following in parts by weight: 250 parts of sargassum, 1.3 parts of monascus orange pigment, 3 parts of stevia leaves, 15 parts of Shanzao, 10 parts of Eucheuma, 15 parts of Gracilaria, 130 parts of edible ethanol, 25 parts of soybean oil, and 90 parts of soybean lecithin.

[0035] The preparation method includes as follows:

[0036] (1) Dried and crushed 250 parts of Sargassum, added 95% ethanol to the dry powder of Sargassum and refluxed for 2 hours, the ratio of dry powder weight to ethanol volume was 1:20g / mL, after the reflux was completed, the ethanol was removed, and dried to obtain dry degreasing Sargassum powder; distilled water is added to the Sargassum powder, wherein the mass of Sargassum and the volume ratio of distilled water are 1:30, and the water extraction method is used to extract at 90°C for 3 hours. Aft...

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Abstract

The invention provides nanoparticles capable of assisting in lowering blood sugar and a preparation method thereof, belonging to the technical field of biological pharmacy. A gulfweed oligosaccharide-stevia rebaudian leaf tea preparation solution used as a water phase and soybean lecithin used as a surfactant are compounded with a red yeast citraurin ethanol solution to obtain gulfweed functional oligosaccharide-citraurin nanoparticles capable of assisting in lowering blood sugar. The nanoparticles have the effect of assisting in lowering blood sugar. By using the nano carrier for embedment, the nanoparticles have the effects of enhancing the stability of blood-sugar-lowering active components, prolonging the acting time and enhancing the blood-sugar-lowering action, and obviously enhance the bioavailability of the functional oligosaccharides and pigments.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and specifically relates to a nanoparticle for assisting blood sugar reduction and a preparation method thereof. Background technique [0002] Diabetes mellitus is a metabolic disease characterized by hyperglycemia, caused by defective insulin secretion or impaired biological action. my country is rich in sargassum resources and widely distributed along the coast. Sargassum has low fat content and is rich in minerals and vitamins. Sargassum polysaccharide has good hypoglycemic activity. Orange pigment is an important part of Monascus pigment, which has certain antibacterial properties. Orange pigment is an intermediate component in the biosynthetic pathway of Monascus pigment, which is easily oxidized or reduced to yellow or red pigment. There are very few studies on orange pigment at home and abroad, and the application in food and other fields has not been fully developed and rese...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/287A61K36/899A61K36/062A61K9/51A61K47/46A61K47/24A61P3/10
CPCA61K9/5123A61K36/02A61K36/062A61K36/236A61K36/287A61K36/899A61K47/46A61K2236/331A61K2300/00
Inventor 赵超杨成凤刘斌吕旭聪陈玉青张璐
Owner FUJIAN AGRI & FORESTRY UNIV
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