41results about How to "Hypoglycemic activity" patented technology

The invention discloses a rosa roxburghii polysaccharide, as well as a preparation method and application thereof. The preparation method mainly comprises raw material pretreatment, extraction, deproteinization, de-coloration, alcohol precipitation, as well as separation and purification, wherein the extraction is to mix pretreated rosa roxburghii dry powder and water in a mass volume ratio of (1to 15) to (1 to 35), and perform extraction at a temperature of 55 to 95 DEG C; perform centrifugal separation to obtain a rosa roxburghii polysaccharide extracting solution, and concentrate the rosaroxburghii polysaccharide extracting solution under reduced pressure to 1 / 3 to 1 / 6 of the original volume to obtain a concentrated solution of the rosa roxburghii polysaccharide. The rosa roxburghii polysaccharide prepared by the invention has the advantages of high purity and uniform molecular weight. Compared with the existing rosa roxburghii polysaccharide, as proved by in-vitro fermentation experiments, the rosa roxburghii polysaccharide disclosed by the invention can promote the generation of short-chain fatty acids such as acetic acid, propionic acid and butyric acid, promote the growthof beneficial bacteria such as lactic acid bacteria and bifidobacterium, and can be taken as prebiotics. Meanwhile, the rosa roxburghii polysaccharide can inhibit the activity of alpha-glucosidase, and can be applied to healthy foods or medicines having auxiliary therapy effects on intestinal diseases and diabetes mellitus.

The invention provides a new high B-ring berberine and palmatine derivative. The structural formula is shown in the description. The invention also provides a preparation technology and application ofthe high B-ring berberine and palmatine derivative. Pharmacodynamic tests prove that the compound provided by the invention has a relatively good effect of reducing blood glucose in vitro and is partially superior to a positive control of berberine hydrochloride. The high B-ring berberine and palmatine derivative provided by the invention has a remarkable drug effect and possibly provides a new clinical medication option.

The invention belongs to the field of medicine, and particularly relates to an oral pharmaceutical composition for treating diabetic. The oral pharmaceutical composition is prepared from, by weight, pharmaceutically acceptable excipients, 11-23 parts of kava piperine B and 5-10 parts of tartaric acid pimavanserin. The oral pharmaceutical composition is granules preferably. Animal experiments showthat a compound of kava piperine B and tartaric acid pimavanserin has good antidiabetic effect and safety.

The invention provides nanoparticles capable of assisting in lowering blood sugar and a preparation method thereof, belonging to the technical field of biological pharmacy. A gulfweed oligosaccharide-stevia rebaudian leaf tea preparation solution used as a water phase and soybean lecithin used as a surfactant are compounded with a red yeast citraurin ethanol solution to obtain gulfweed functional oligosaccharide-citraurin nanoparticles capable of assisting in lowering blood sugar. The nanoparticles have the effect of assisting in lowering blood sugar. By using the nano carrier for embedment, the nanoparticles have the effects of enhancing the stability of blood-sugar-lowering active components, prolonging the acting time and enhancing the blood-sugar-lowering action, and obviously enhance the bioavailability of the functional oligosaccharides and pigments.

The invention discloses a wakame polysaccharide and its application in the preparation of α-glucosidase activity inhibiting drugs. The two polysaccharides Up-3 and Up-4 prepared by the present invention have characteristic molecular weights of 78-282 kDa and 41-314 kDa respectively; Up-3 is mainly composed of glucuronic acid, mannose and fucose, and Up-4 is mainly composed of Composition of rhamnose, glucuronic acid and fucose; IC for α-glucosidase inhibitory activity 50 The values ​​were 113.40±3.02μg / mL and 50.53±3.47μg / mL, respectively, and significantly inhibited the increase in blood sugar caused by oral administration of maltose. This shows that the sulfated polysaccharides Up-3 and Up-4 can reduce the level of postprandial blood sugar by inhibiting the activity of α-glucosidase in the intestine, thereby achieving the hypoglycemic effect.

The present invention relates to a process for isolating plant Argyrobium roseum extract that contains flavonoid glycoside, wherein the extract possesses hypoglycaemic activity. The present invention also contemplates a composition containing the extract and a method of treating various hyperglycaemic conditions including non-insulin dependent diabetes mellitus disease condition by administering the extract.

A preparation method and application of a highly active tetranuclear polymer. The invention discloses a tetranuclear copper compound containing difluorooxamide ligand and its preparation method and application. Dissolve the copper salt in 5-10ml of methanol and add it to the methanol solution of the above-mentioned mononuclear copper ligand, react at 60°C for 1 hour, then add the methanol solution containing 2mmol of 1,10-phenanthroline ligand to the above-mentioned ligand Reflux at 60°C for 5 hours, filter, and slowly volatilize the filtrate for 1 week to obtain blue blocky crystals. That is, it is a tetranuclear copper compound containing difluorooxamide ligand, and the copper salts are: copper perchlorate, copper chloride, copper bromide and the like. Compared with the platinum anti-cancer commonly used at present, the compound of the present invention has the characteristics of high anti-cancer activity, low cost, simple preparation method and the like. At the same time, it was found for the first time that the synthesized compound has a high activity in reducing blood sugar, which provides a new way for the development of drugs for related purposes.