A kind of preparation method and application of highly active tetranuclear polymer

A copper compound, mononuclear technology, applied in the application field of anti-diabetic drugs, can solve problems such as no reports on research, and achieve the effects of simple preparation method, low cost and high activity

Active Publication Date: 2021-06-29
WEIFANG MEDICAL UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing research on hypoglycemic drugs, there are many reports on PTP1B inhibitors, but there is no report on the PTP1B inhibitory activity of this class of compounds

Method used

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  • A kind of preparation method and application of highly active tetranuclear polymer
  • A kind of preparation method and application of highly active tetranuclear polymer
  • A kind of preparation method and application of highly active tetranuclear polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Dissolve 2 mmol of oxamide mononuclear copper ligand in 10 ml of methanol, dissolve 2 mmol of copper perchlorate in 5 ml of methanol, add it to the methanol solution of the above mononuclear copper ligand, react at 60 ° C for 1 hour, and then dissolve the dissolved Add 2 mmol of 1,10-phenanthroline ligand methanol solution to the mixture of the above ligands, reflux at 60°C for 5 hours, filter, and the filtrate slowly volatilizes for 1 week to obtain blue blocky crystals, which are difluorinated Amide Ligand Tetranuclear Copper Compounds.

[0018] Infrared, elemental analysis and X-ray single crystal diffraction results:

[0019] Infrared spectrum (KBr, cm -1 ):ν(N-H)3419νas(C=O)16281574;ν s (C6H6-H) 1464 726

[0020] Elemental analysis: Calculated: C, 42.39; H, 3.43; N, 9.15%. Found: C, 42.37; H, 3.45; N, 9.16%.

[0021] X-ray single crystal diffraction results:

[0022]

[0023] Molecular structural formula of tetranuclear copper compound containing difluoroox...

Embodiment 2

[0028] Dissolve 2 mmol of the oxamide mononuclear copper ligand in 20 ml of methanol, dissolve 2 mmol of copper chloride in 10 ml of methanol, add it to the methanol solution of the above mononuclear copper ligand, react at 60 ° C for 1 hour, and then dissolve 2 mmol The methanol solution of 1,10-phenanthroline ligand was added to the mixture of the above ligands, refluxed at 60°C for 5 hours, filtered, and the filtrate was slowly volatilized for 1 week to obtain blue blocky crystals. It is tetranuclear copper compound containing difluorooxamide ligand.

Embodiment 3

[0030] Dissolve 2 mmol of oxamide mononuclear copper ligand in 10 ml of methanol, dissolve 2 mmol of copper bromide in 5 ml of methanol and add it to the methanol solution of the above mononuclear copper ligand, react at 60 ° C for 1 hour, and then dissolve 2 mmol The methanol solution of 1,10-phenanthroline ligand was added to the mixture of the above ligands, refluxed at 60°C for 5 hours, filtered, and the filtrate was slowly volatilized for 1 week to obtain blue blocky crystals. It is tetranuclear copper compound containing difluorooxamide ligand.

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Abstract

A preparation method and application of a highly active tetranuclear polymer. The invention discloses a tetranuclear copper compound containing difluorooxamide ligand and its preparation method and application. Dissolve the copper salt in 5-10ml of methanol and add it to the methanol solution of the above-mentioned mononuclear copper ligand, react at 60°C for 1 hour, then add the methanol solution containing 2mmol of 1,10-phenanthroline ligand to the above-mentioned ligand Reflux at 60°C for 5 hours, filter, and slowly volatilize the filtrate for 1 week to obtain blue blocky crystals. That is, it is a tetranuclear copper compound containing difluorooxamide ligand, and the copper salts are: copper perchlorate, copper chloride, copper bromide and the like. Compared with the platinum anti-cancer commonly used at present, the compound of the present invention has the characteristics of high anti-cancer activity, low cost, simple preparation method and the like. At the same time, it was found for the first time that the synthesized compound has a high activity in reducing blood sugar, which provides a new way for the development of drugs for related purposes.

Description

technical field [0001] The invention relates to a preparation method of a fluorine-containing oxamide ligand tetranuclear copper compound, and the application of the compound in the preparation of anticancer drugs and antidiabetic drugs. Background technique [0002] Since the discovery of cisplatin, transition metal compounds with targeting functions on proteins and DNA have attracted people's attention in the field of anticancer drugs. However, the research on oxamide coordination compounds mostly focuses on the field of catalysis and molecular magnetism. In recent years, more and more researchers Application of oxamide complexes in the research of anticancer drugs. [0003] Type II diabetes, as an endocrine disorder and metabolic disease, has become the third chronic disease that seriously threatens human health after tumors and cardiovascular diseases. In the existing research on hypoglycemic drugs, there are many reports on PTP1B inhibitors, but there is no report on ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F1/08A61P35/00A61P3/10
CPCA61P3/10A61P35/00C07B2200/13C07F1/005
Inventor 宋伟国胡亚杰王西龙李法辉郭守东甲宗青杨振勇
Owner WEIFANG MEDICAL UNIV
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