Preparation method and application of high-activity tetranuclear polymer
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A copper compound and mononuclear technology, applied in the application field of anti-diabetic drugs, can solve the problems that have not been reported in the research, and achieve the effect of simple preparation method, high activity and low cost
Active Publication Date: 2019-10-11
WEIFANG MEDICAL UNIV +1
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In the existing research on hypoglycemic drugs, there are many reports on PTP1B inhibitors, but there is no report on the PTP1B inhibitory activity of this class of compounds
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Embodiment 1
[0017] Dissolve 2 mmol of oxamide mononuclear copper ligand in 10 ml of methanol, dissolve 2 mmol of copper perchlorate in 5 ml of methanol, add it to the methanol solution of the above mononuclear copper ligand, react at 60 ° C for 1 hour, and then dissolve the dissolved Add 2 mmol of 1,10-phenanthroline ligand methanol solution to the mixture of the above ligands, reflux at 60°C for 5 hours, filter, and the filtrate slowly volatilizes for 1 week to obtain blue blocky crystals, which are difluorinated Amide Ligand Tetranuclear Copper Compounds.
[0018] Infrared, elemental analysis and X-ray single crystal diffraction results:
[0019] Infrared spectrum (KBr, cm -1 ):ν(N-H)3419νas(C=O)16281574;ν s (C6H6-H) 1464 726
[0020] Elemental analysis: Calculated: C, 42.39; H, 3.43; N, 9.15%. Found: C, 42.37; H, 3.45; N, 9.16%.
[0021] X-ray single crystal diffraction results:
[0022]
[0023] Molecular structural formula of tetranuclear copper compound containing difluoroox...
Embodiment 2
[0028] Dissolve 2 mmol of the oxamide mononuclear copper ligand in 20 ml of methanol, dissolve 2 mmol of copper chloride in 10 ml of methanol, add it to the methanol solution of the above mononuclear copper ligand, react at 60 ° C for 1 hour, and then dissolve 2 mmol The methanol solution of 1,10-phenanthroline ligand was added to the mixture of the above ligands, refluxed at 60°C for 5 hours, filtered, and the filtrate was slowly volatilized for 1 week to obtain blue blocky crystals. It is tetranuclear copper compound containing difluorooxamide ligand.
Embodiment 3
[0030] Dissolve 2 mmol of oxamide mononuclear copper ligand in 10 ml of methanol, dissolve 2 mmol of copper bromide in 5 ml of methanol and add it to the methanol solution of the above mononuclear copper ligand, react at 60 ° C for 1 hour, and then dissolve 2 mmol The methanol solution of 1,10-phenanthroline ligand was added to the mixture of the above ligands, refluxed at 60°C for 5 hours, filtered, and the filtrate was slowly volatilized for 1 week to obtain blue blocky crystals. It is tetranuclear copper compound containing difluorooxamide ligand.
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Abstract
The invention relates to a preparation method and application of a high-activity tetranuclear polymer, and discloses a tetranuclear copper compound containing difluoro-oxamide ligands, and a preparation method and application thereof. The structural formula of the tetranuclear copper compound is shown as below. The preparation method includes the following steps: dissolving 2 mmol of oxamide mononuclear copper ligands in 10-20 ml of methanol, dissolving 2mmol of copper salts in 5-10 ml of methanol, adding the dissolved copper salts to the methanol solution of the mononuclear copper ligands tocarry out a reaction at 60 DEG C for 1 hour, adding a methanol solution, in which 2 mmol of 1,10-phenanthroline ligands are dissolved, to the mixed solution of the ligands, carrying out reflux at 60 DEG C for 5 hours before filtering, and slowly volatilizing filter liquor for 1 week to obtain a blue blocky crystal, namely the tetranuclear copper compound containing the difluoro-oxamide ligands. The copper salts include copper perchlorate, copper chloride, copper bromide and the like. Compared with currently used platinum-based anticancer compounds, the tetranuclear copper compound has the advantages of high anticancer activity, low cost, simplicity in preparation, and the like. It is found for the first time that the synthesized compound has high activity in sugar reduction, providing a new way for developing related drugs.
Description
technical field [0001] The invention relates to a preparation method of a fluorine-containing oxamide ligand tetranuclear copper compound, and the application of the compound in the preparation of anticancer drugs and antidiabetic drugs. Background technique [0002] Since the discovery of cisplatin, transition metal compounds with targeting functions on proteins and DNA have attracted people's attention in the field of anticancer drugs. However, the research on oxamide coordination compounds mostly focuses on the field of catalysis and molecular magnetism. In recent years, more and more researchers Application of oxamide complexes in the research of anticancer drugs. [0003] Type II diabetes, as an endocrine disorder and metabolic disease, has become the third chronic disease that seriously threatens human health after tumors and cardiovascular diseases. In the existing research on hypoglycemic drugs, there are many reports on PTP1B inhibitors, but there is no report on ...
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