Undaria pinnatifida extract polysaccharides and applications thereof in preparation of alpha-glucosidase activity inhibition drugs

A technology of undaria pinnatifida and undaria pinnatifida, which is applied in the application field of preparing α-glucosidase activity inhibitory drugs, and achieves the effects of easy operation, strong inhibitory effect, and low process cost
CN111116771AActive Publication Date: 2020-05-08ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2020-05-08

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Abstract

The invention discloses Undaria pinnatifida polysaccharides and applications of the Undaria pinnatifida polysaccharides in the preparation of alpha-glucosidase activity inhibition drugs. The characteristic molecular weights of the two polysaccharides Up-3 and Up-4 are 78-282 kDa and 41-314 kDa respectively; the Up-3 is mainly composed of glucuronic acid, mannose and fucose, and the Up-4 is mainlycomposed of rhamnose, glucuronic acid and fucose; and the IC50 values of the alpha-glucosidase inhibitory activity of the Up-3 and Up-4 are 113.40 + / -3.02 [mu]g / mL and 50.53 + / -3.47 [mu]g / mL respectively, and the Up-3 and Up-4 have the effect of remarkably inhibiting blood glucose rise caused by oral maltose. Therefore, the sulfated polysaccharides Up-3 and Up-4 can reduce the postprandial blood sugar level by inhibiting the activity of alpha-glucosidase in intestinal tracts so as to achieve the effect of reducing blood sugar.
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Description

technical field

[0001] The invention relates to two sulfated polysaccharides derived from wakame seaweed and the application thereof in the preparation of α-glucosidase activity inhibiting drugs. Background technique

[0002] Diabetes is a chronic metabolic disorder with high blood sugar caused by insulin resistance or insufficient insulin secretion. In recent years, the number of people with diabetes in the world has increased year by year. The number of people with diabetes in the world has reached 425 million and this number is estimated to reach 462 million in 2040 (IDF Diabetes Atlas), of which WHO (2018) reported that about 90% of diabetic patients were diagnosed with type 2 diabetes. Type 2 diabetes is mainly characterized by defects in insulin secretion and insulin resistance. In the early stage of the onset, hyperglycemia is finally caused by increased hepatic glucose production and decreased peripheral glucose uptake.

[0003] α-glucosidase is an important digesti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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