Multi-material gradient mixed liquid drop formation device based on micro-fluidic chip

Abstract

The invention provides a multi-material gradient mixed liquid drop formation device based on a micro-fluidic chip. The device comprises an upper layer micro-fluidic chip, a middle layer micro-fluidic chip and a lower layer plate chip. Solution entrances, microchannel networks and solution exits are arranged on the upper layer micro-fluidic chip and the middle layer micro-fluidic chip respectively; the microchannel networks of the upper layer micro-fluidic chip and the middle layer micro-fluidic chip are composed of concentric annular channels and radial subchannels with same quantity which are connected in an alternatively distributed mode respectively; the solution entrances of the upper layer micro-fluidic chip and the middle layer micro-fluidic chip are communicated with the first concentric annular channel and the first set of radial subchannels in same-layer chip microchannel networks respectively; the solution exits of the upper layer micro-fluidic chip and the middle layer micro-fluidic chip are communicated with the last set of radial subchannels in the same-layer chip microchannel networks respectively, and the solution exits of the upper layer micro-fluidic chip is communicated with the solution exits of the middle layer micro-fluidic chip and corresponds to the solution exits of the middle layer micro-fluidic chip one to one.

Description

technical field

[0001] The invention belongs to the technical field of chemical analysis, and in particular relates to a multi-substance gradient mixed droplet forming device based on a microfluidic chip. Background technique

[0002] In drug sustained-release research, the preparation of sustained-release drug-loaded particles is the first work to be done. Because it is necessary to investigate the combined therapeutic effect of different drugs and the dosage ratio of different drugs, the synthesis and preparation of particles with different contents and contents with different ratios are often involved in the particle synthesis process. In the field of analytical chemistry, analysis and detection based on suspension microcarriers is a widely used detection technology. The suspension carriers used are generally spherical particles with luminescent properties. In the detection, the identification of the particles is realized by identifying the difference in the optical sign...

Examples

Embodiment 1

[0040] A microfluidic chip-based multi-substance gradient mixed droplet forming device, its structure is as follows figure 1 As shown, it includes the upper microfluidic chip 2, the middle microfluidic chip 3 and the lower flat plate chip 4, and the material of each chip is polydimethylsiloxane, wherein the upper microfluidic chip 2 and the middle microfluidic chip 3 are respectively provided with 4 solution inlets, 3 concentric circular channels and 3 groups of radial branch channels, and solution outlets; the upper microfluidic chip 2 is also provided with the middle microfluidic chip The solution inlets are connected and correspond to the four through holes 10 one by one, and the four solution inlets 5 and the four through holes 10 of the upper microfluidic chip are all located in the first concentric circular channel 71 at the center of the chip and the first group of radial branch passages, and each along the first concentric circular passage 71 is center-symmetrically di...

Embodiment 2

[0053] The multi-substance gradient mixed droplet forming device based on the microfluidic chip of this embodiment is the same as that of Embodiment 1, the difference is that the number of solution inlets on the upper microfluidic chip and the middle microfluidic chip are 2 respectively, and the upper microfluidic chip The number of through holes in the control chip is 2, the number of concentric circular channels and radial branch channels on the two-layer microfluidic chip is 4; the number of independent branch channels in the first group of radial branch channels is 4, and the number of There are 8 in the second group, 16 in the third group, and 32 in the fourth group; the radii of the 4 concentric circular channels arranged in sequence from the direction of the center to the outside are: 0.4 mm, 4.0mm, 6 mm, 8.0 mm; the lengths of independent branch channels in the first group to the fourth group of radial branch channels were 40 mm, 25 mm, 14 mm, and 8 mm, respectively. T...

technical field

[0001] The invention belongs to the technical field of chemical analysis, and in particular relates to a multi-substance gradient mixed droplet forming device based on a microfluidic chip. Background technique

[0002] In drug sustained-release research, the preparation of sustained-release drug-loaded particles is the first work to be done. Because it is necessary to investigate the combined therapeutic effect of different drugs and the dosage ratio of different drugs, the synthesis and preparation of particles with different contents and contents with different ratios are often involved in the particle synthesis process. In the field of analytical chemistry, analysis and detection based on suspension microcarriers is a widely used detection technology. The suspension carriers used are generally spherical particles with luminescent properties. In the detection, the identification of the particles is realized by identifying the difference in the optical sign...

Examples

Embodiment 1

[0040] A microfluidic chip-based multi-substance gradient mixed droplet forming device, its structure is as follows figure 1 As shown, it includes the upper microfluidic chip 2, the middle microfluidic chip 3 and the lower flat plate chip 4, and the material of each chip is polydimethylsiloxane, wherein the upper microfluidic chip 2 and the middle microfluidic chip 3 are respectively provided with 4 solution inlets, 3 concentric circular channels and 3 groups of radial branch channels, and solution outlets; the upper microfluidic chip 2 is also provided with the middle microfluidic chip The solution inlets are connected and correspond to the four through holes 10 one by one, and the four solution inlets 5 and the four through holes 10 of the upper microfluidic chip are all located in the first concentric circular channel 71 at the center of the chip and the first group of radial branch passages, and each along the first concentric circular passage 71 is center-symmetrically di...

Embodiment 2

[0053] The multi-substance gradient mixed droplet forming device based on the microfluidic chip of this embodiment is the same as that of Embodiment 1, the difference is that the number of solution inlets on the upper microfluidic chip and the middle microfluidic chip are 2 respectively, and the upper microfluidic chip The number of through holes in the control chip is 2, the number of concentric circular channels and radial branch channels on the two-layer microfluidic chip is 4; the number of independent branch channels in the first group of radial branch channels is 4, and the number of There are 8 in the second group, 16 in the third group, and 32 in the fourth group; the radii of the 4 concentric circular channels arranged in sequence from the direction of the center to the outside are: 0.4 mm, 4.0mm, 6 mm, 8.0 mm; the lengths of independent branch channels in the first group to the fourth group of radial branch channels were 40 mm, 25 mm, 14 mm, and 8 mm, respectively. T...

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