Secondary forming process of medical film-coated rubber plug

Abstract

The invention relates to a secondary forming process of a medical film-coated rubber plug. The secondary forming process comprises the following specific steps: (1) rubber raw material are prepared by 100 phr of halogenated butyl rubber, 50-80 phr of calcined kaolin, 3-10 phr of zinc oxide, 1-2 phr of stearic acid, 1-5 phr of vulcanized resins and 1-5 phr of pigment; (2) a plug neck is formed through once mold pressing; and the 2 / 3 peripheral wall of the plug neck and the bottom surface of the plug neck are coated with film layers; and (3) the film-coated plug neck is mounted in a mold; and the rubber raw materials are filled for secondary mold pressing, so that the film-coated plug neck is combined with a plug head as a whole. The secondary forming process has the following beneficial effects: the secondary forming process of the medical film-coated rubber plug is to coat the film at the plug neck part, directly contacted with medicines, of the rubber plug through an unique secondary forming technology to isolate direct contact between rubber and the medicines so as to prevent pollution of the medicines by the rubber plug; and the sealing surface of the rubber plug is not coated with a film, so that the rubber plug keeps proper elastic sealing effect.

Description

technical field [0001] The invention belongs to the field of medical rubber stoppers, in particular to a secondary molding process of medical film-coated rubber stoppers. Background technique [0002] As a sealing material directly in contact with medicines, medicinal rubber stoppers must have excellent airtightness, good chemical stability and biological inertness. On the one hand, the medicinal rubber stopper itself cannot interact with the raw materials of the drug to affect the quality of the drug. [0003] The existing materials used in the production of medical rubber stoppers mainly include natural rubber, polyisoprene rubber, butyl rubber and halogenated butyl rubber. Under normal circumstances, various compounding agents are added to mix evenly and then made by molding process made. Various compounding agents in the matching system that support the formation of rubber stopper characteristics have different chemical activities. When the rubber stopper is in direct ...

AI Technical Summary

Problems solved by technology

So strictly speaking, the impact of the rubber stopper on the stability of the sealed medicine is not whether there is a problem, but how long and how much it will pollute the medicine.

At the same time, due to the great difference in the activity of the drug itself, and the emergence of new drugs, so far, the medicinal rubber sealing ring is limited by the material material and formula level, and there is no unique formula that can meet the relative requirements of all drug raw materials. capacity

[0004] While the existing film coating technology solves the compatibility problem in the direct contact between the rubber stopper and the medicine, it affects the tightness between the rubber stopper and the glass bottle mouth, that is, it affects the sealing effect on the medicine.

Because of the existing coating technology, regardless of double-sided or single-sided coating, the sealing surface of the rubber stopper is also coated, so that the lubricating effect of the smooth surface of the film will affect the use of rubber to elastically seal the glass bottle mouth.

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