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Medical devices with non-uniform coatings for enhanced echogenicity

A technology for medical devices and coatings, applied in the fields of physics, biology, and medicine, can solve the problems of difficult to obtain ultrasonic imaging coatings, difficult to control the concentration and size of bubbles, etc.

Active Publication Date: 2017-03-01
ENCAPSON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of air bubbles to improve ultrasound visibility has the disadvantage that it is difficult to control the concentration and size of the bubbles formed, leading to coating-to-coat variation, making it more difficult to achieve optimal coatings for ultrasound imaging

Method used

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  • Medical devices with non-uniform coatings for enhanced echogenicity
  • Medical devices with non-uniform coatings for enhanced echogenicity
  • Medical devices with non-uniform coatings for enhanced echogenicity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0130] Commercially available solid glass microspheres (from Cospheric) ranging in diameter from 10 μm to 22 μm, 22 μm to 27 μm, 27 μm to 32 μm, 32 μm to 38 μm, 38 μm were thoroughly mixed in the polyurethane coating matrix to 45 μm and 45 μm to 53 μm, all of the solid glass microspheres have a density of 2.5 g / mL. Microspheres were added in varying amounts to prepare mixtures containing 0.5 vol.% to 75.0 vol.% microspheres in the coating matrix. Subsequently, coating films of 30 μm or 60 μm thickness were drawn on both glass slides and PEBAX 6233 sheets as substrates using a film maker. It has been determined that the density of the microspheres ranges from 2 particles / mm 2 Up to 1831 particles / mm 2 Variety.

[0131] Coated substrates were measured ultrasonically using a 33 mm line array probe operated in brightness mode (B-mode) at 6 MHz. At an angle of approximately 45 degrees, the substrate was placed within a commercially available ultrasonic phantom that served as th...

Embodiment 2

[0137] Commercially available solid glass microspheres ranging in diameter from 10 μm to 22 μm, 22 μm to 27 μm, 27 μm to 32 μm, 32 μm to 38 μm, 38 μm to 45 μm, and 45 μm were thoroughly mixed in the polyurethane coating matrix All of the solid glass microspheres have a density of 2.5 g / mL to 53 μm. Microspheres were added in varying amounts to prepare mixtures containing 0.5 vol.% to 75.0 vol.% microspheres in the coating matrix. Subsequently, 30 μm or 60 μm thick test strips were drawn on glass slides using a film maker. These test strips were applied by masking the areas that were not to be coated. Measure the width of the test strip.

[0138] Coated substrates were measured ultrasonically using a 33 mm line array probe operated in brightness mode (B-mode) at 6 MHz. At an angle of approximately 45 degrees, the substrate was placed within a commercially available ultrasound body membrane that served as the medium.

[0139] Determine the width of the test strip visible und...

Embodiment 3

[0150] Solid glass microspheres ranging in diameter from 38 to 45 μm with a density of 2.5 g / mL were thoroughly mixed in the polyurethane coating matrix as described above. These particles were subsequently coated on glass slides and plastic (PEBAX 6233) at different densities. Coated substrates were measured ultrasonically using a 33 mm line array probe operated in brightness mode (B-mode) at 6 MHz. At an angle of approximately 45 degrees, the substrate was placed within a commercially available ultrasound body membrane that served as the medium. In the same manner as described in Example 1, the contrast-to-noise ratio (CNR) was determined from the recorded images, and the determined CNR was plotted against the microsphere concentration ( Figure 7 ).

[0151] Such as Figure 7 As can be seen in , the CNR values ​​for glass and plastic coated with the same amount of particles are comparable. This confirms that the material of the surface used does not significantly affect...

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Abstract

The invention provides medical devices comprising improved non-uniform coatings for ultrasound detection, which provide optimal ultrasound images. Methods for preparing such devices are also provided.

Description

technical field [0001] The invention relates to the fields of medicine, physics and biotechnology. Background technique [0002] To precisely position a medical device (eg, a needle or catheter) within a patient, ultrasound imaging is often used. Ultrasound imaging relies on different ways of reflecting sound waves from interfaces between substances. Ultrasonic waves with frequencies exceeding the audible range of normal human hearing, typically from 20 kHz up to several gigahertz, are reflected in areas with density differences. In practice, transducers that emit ultrasonic waves are used. Some of the reflected sound waves are detected by transducers, which convert the vibrations into electrical impulses. These electrical impulses are processed and converted into digital images. [0003] The use of ultrasound imaging in medical devices is well known in the art. To improve the quality of ultrasound images of medical devices, the surface of such devices is typically groo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/14A61L31/08A61L31/18
CPCA61L29/08A61L29/14A61L31/08A61L31/18A61L29/18A61L29/126A61L31/125A61L2420/04A61L2420/02A61L31/088
Inventor 李·埃里斯大卫·阿斯里安约翰内斯·安东尼斯·奥普斯廷丹尼斯·曼纽尔·弗里泽马
Owner ENCAPSON
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