Topical spraying agent containing desonide
A technology of spray and desonide, which is applied in the field of topical spray containing desonide to achieve the effect of large spray area, avoiding adverse reactions and stable quality
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Embodiment 1
[0030] The preparation of embodiment 1 desonide spray of the present invention
[0031] Desonide spray prescription of the present invention consists of:
[0032] Material mass percentage material quantity Desonide 0.05% 0.5g benzalkonium chloride 0.77% 7.7g Propylene Glycol 3.12% 31.2g Absolute ethanol 15.13% 151.3g Edetate Disodium 0.11% 1.1g Tween 80 0.51% 5.1g tartaric acid 0.04% 0.4g sodium tartrate 0.13% 1.3g purified water Fixed weight to 100% Fixed weight to 1000g
[0033] Preparation method: Weigh the prescribed amount of purified water, absolute ethanol, disodium edetate, Tween 80 and benzalkonium chloride, stir and dissolve completely; wet and disperse the prescribed amount of desonide with propylene glycol and add it to the solution. Stir to make it fully dispersed; add tartaric acid and sodium citrate to adjust the pH to 4.5-7; dispense the liquid medicine into a specific spray bottl...
Embodiment 2
[0034] Embodiment 2 Preparation of desonide spray of the present invention
[0035] Desonide spray prescription of the present invention consists of:
[0036] Material mass percentage material quantity Desonide 0.05% 0.5g 2-Phenoxyethanol 0.81% 8.1g glycerin 4.92% 49.2g Absolute ethanol 10.05% 100.5g Edetate Disodium 0.09% 0.9g citric acid 0.05% 0.5g sodium hydroxide 0.10% 1.0g purified water Fixed weight to 100% Fixed weight to 1000g
[0037] Preparation method: Weigh the prescribed amount of purified water, absolute ethanol, edetate disodium and 2-phenoxyethanol, stir and dissolve completely; add the prescribed amount of desonide to the solution after wetting and dispersing with glycerin, and stir to make It is fully dispersed; citric acid and sodium hydroxide are added to adjust the pH to 4.5-7; the liquid medicine is divided into specific spray bottles, and the pump head is sealed to obtain the deso...
Embodiment 3
[0038] Embodiment 3 Preparation of desonide spray of the present invention
[0039] Desonide spray prescription of the present invention consists of:
[0040] Material mass percentage material quantity Desonide 0.05% 0.5g benzalkonium chloride 0.47% 4.7g Absolute ethanol 4.98% 49.8g Edetate Disodium 0.05% 0.5g Hydroxypropylmethylcellulose 0.36% 3.6g Lecithin 0.39% 3.9g tartaric acid 0.03% 0.3g sodium hydroxide 0.11% 1.1g purified water Fixed weight to 100% Fixed weight to 1000g
[0041] Preparation method: Weigh the prescribed amount of purified water, desonide, absolute ethanol, edetate disodium, lecithin, hydroxypropyl methylcellulose and benzalkonium chloride, stir to disperse completely; add tartaric acid and Sodium hydroxide is used to adjust the pH to 4.5-7; the liquid medicine is dispensed into specific spray bottles, and the pump head is added to seal it to obtain the desonide spray of th...
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