Topical spraying agent containing desonide

A technology of spray and desonide, which is applied in the field of topical spray containing desonide to achieve the effect of large spray area, avoiding adverse reactions and stable quality

Inactive Publication Date: 2017-03-08
CHONGQING HUAPONT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, the stability of the above-mentioned existing product and the problem of product content uniformity are also one of the problems to be solved in the development of desonide spray

Method used

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  • Topical spraying agent containing desonide
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  • Topical spraying agent containing desonide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of embodiment 1 desonide spray of the present invention

[0031] Desonide spray prescription of the present invention consists of:

[0032] Material mass percentage material quantity Desonide 0.05％ 0.5g benzalkonium chloride 0.77％ 7.7g Propylene Glycol 3.12％ 31.2g Absolute ethanol 15.13％ 151.3g Edetate Disodium 0.11％ 1.1g Tween 80 0.51％ 5.1g tartaric acid 0.04％ 0.4g sodium tartrate 0.13％ 1.3g purified water Fixed weight to 100% Fixed weight to 1000g

[0033] Preparation method: Weigh the prescribed amount of purified water, absolute ethanol, disodium edetate, Tween 80 and benzalkonium chloride, stir and dissolve completely; wet and disperse the prescribed amount of desonide with propylene glycol and add it to the solution. Stir to make it fully dispersed; add tartaric acid and sodium citrate to adjust the pH to 4.5-7; dispense the liquid medicine into a specific spray bottl...

Embodiment 2

[0034] Embodiment 2 Preparation of desonide spray of the present invention

[0035] Desonide spray prescription of the present invention consists of:

[0036] Material mass percentage material quantity Desonide 0.05％ 0.5g 2-Phenoxyethanol 0.81％ 8.1g glycerin 4.92％ 49.2g Absolute ethanol 10.05％ 100.5g Edetate Disodium 0.09％ 0.9g citric acid 0.05％ 0.5g sodium hydroxide 0.10％ 1.0g purified water Fixed weight to 100% Fixed weight to 1000g

[0037] Preparation method: Weigh the prescribed amount of purified water, absolute ethanol, edetate disodium and 2-phenoxyethanol, stir and dissolve completely; add the prescribed amount of desonide to the solution after wetting and dispersing with glycerin, and stir to make It is fully dispersed; citric acid and sodium hydroxide are added to adjust the pH to 4.5-7; the liquid medicine is divided into specific spray bottles, and the pump head is sealed to obtain the deso...

Embodiment 3

[0038] Embodiment 3 Preparation of desonide spray of the present invention

[0039] Desonide spray prescription of the present invention consists of:

[0040] Material mass percentage material quantity Desonide 0.05％ 0.5g benzalkonium chloride 0.47％ 4.7g Absolute ethanol 4.98％ 49.8g Edetate Disodium 0.05％ 0.5g Hydroxypropylmethylcellulose 0.36％ 3.6g Lecithin 0.39％ 3.9g tartaric acid 0.03％ 0.3g sodium hydroxide 0.11％ 1.1g purified water Fixed weight to 100% Fixed weight to 1000g

[0041] Preparation method: Weigh the prescribed amount of purified water, desonide, absolute ethanol, edetate disodium, lecithin, hydroxypropyl methylcellulose and benzalkonium chloride, stir to disperse completely; add tartaric acid and Sodium hydroxide is used to adjust the pH to 4.5-7; the liquid medicine is dispensed into specific spray bottles, and the pump head is added to seal it to obtain the desonide spray of th...

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Abstract

The invention belongs to the field of pharmaceutical preparations, relates to a pharmaceutical preparation containing desonide, and specifically relates to a topical spraying agent containing the desonide. A drug contained in the topical desonide spraying agent is a stable-quality desonide drug containing desonide micro powder, and the desonide drug comprises, by weight, 0.05%-0.2% of the desonide micro powder and balance of pharmaceutically acceptable excipients. The topical desonide spraying agent is sprayed directly on a site of action, and is uniform to distribute, the effect is fast to take, in addition, by use of a direct spray method, contact with microorganism is reduced, by use of a closed dark storage container, contact with water and oxygen in the air can be avoided, and the drug stability can be improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a pharmaceutical preparation containing desonide, in particular to an external spray containing desonide. Background technique [0002] Desonide is a weak glucocorticoid drug in the genus, which has anti-inflammatory, anti-allergic, antipruritic and anti-exudation effects; by affecting the transcription of some genes involved in inflammation, it can reduce and prevent tissue responses to inflammation and eliminate local inflammation. Heat, redness, and swelling caused by non-infectious inflammation, thereby reducing the manifestations of inflammation; has an immunosuppressive effect: prevent or inhibit cellular immune responses, and inhibit the initial immune response. The topical preparations of desonide can be used for the treatment of various hormone-sensitive skin diseases such as contact dermatitis, neurodermatitis, seborrheic dermatitis, eczema, psoriasis, lichen pl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/58A61K47/42A61K47/38A61K47/36A61K47/10A61P17/00
Inventor 传娜陈李平管璐晗陈博赵静
Owner CHONGQING HUAPONT PHARMA
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