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A kind of hydrogel patch for smoking cessation and preparation method thereof

A technology of hydrogel patch and purified water, which is applied in the direction of pharmaceutical formulations, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of unguaranteed safety, lack of safety evaluation, skin Strong irritation and other issues, to achieve the effect of low damage, safe use, and stable absorption area

Active Publication Date: 2019-10-01
NANJING TECH UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of patch has poor skin affinity and is more irritating to the skin due to the use of organic solvents
[0004] The hydrogel smoking cessation patch announced by Chinese patent 104940408A adopts a hydrogel with better skin affinity, but its transdermal property is not as good as the aforementioned prior art
At the same time, this technology uses ethanol as an amphiphilic solvent, which is volatile and has poor stability.
In addition, the tobacco extract and nicotine inclusion compound used in this technology introduce other components other than nicotine, the key smoking cessation component, and lack the necessary safety evaluation, so the safety cannot be guaranteed

Method used

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  • A kind of hydrogel patch for smoking cessation and preparation method thereof
  • A kind of hydrogel patch for smoking cessation and preparation method thereof
  • A kind of hydrogel patch for smoking cessation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 6 grams of polyacrylic acid and sodium polyacrylate copolymer, 1 gram of nicotine, add to the mixing container of the vacuum mixer, add 20 grams of glycerin and stir to form a thick paste liquid, then add 5 grams of azone, 0.3 grams of eucalyptus oil gram, 1 gram of castor oil, 0.1 gram of glycylic aluminum; mix 1 gram of polyvinyl alcohol, 5 grams of polyvinylpyrrolidone, 0.5 grams of sodium carboxymethylcellulose, 0.5 grams of tartaric acid, and 1 gram of disodium edetate Add an appropriate amount of purified water to disperse and dissolve evenly, slowly add to the above glycerin solution, and stir evenly to obtain 100 g of viscous colloid.

[0027] Using hydrogel coating equipment, after the hydrogel is coated on the backing material, the material is covered and weighed, and the coating and covering of the hydrogel patch are completed. After curing and molding, it is cut into an appropriate size for packaging. The hydrogel patch for smoking cessation is obtaine...

Embodiment 2

[0030] Weigh 4 grams of polyacrylic acid and sodium polyacrylate copolymer, 3 grams of nicotine, add to the mixing container of the vacuum mixer, add 30 grams of glycerin and stir to form a thick paste liquid, then add 2 grams of azone, 0.1 grams of eucalyptus oil gram, 2 grams of castor oil, 0.5 grams of glyoxate, mixed evenly; 1.2 grams of cross-linked polyvinylpyrrolidone, 1 gram of polyvinylpyrrolidone, 6 grams of sodium carboxymethyl cellulose, 1.5 grams of tartaric acid, disodium edetate Add an appropriate amount of purified water to 0.5 g to disperse and dissolve evenly, slowly add to the above glycerin solution, stir evenly to obtain 100 g of viscous colloid, which is coated and pressed into shape.

[0031] Take the SD mouse skin and fix it between the supply pool and the receiving pool of the transdermal device, so that the cuticle faces the supply pool, put in 0.9% saline receiving solution, and drain the air bubbles in the receiving pool so that the liquid surface of...

Embodiment 3

[0033] Weigh 5 grams of polyacrylic acid and sodium polyacrylate copolymer, 4 grams of nicotine, add to the mixing container of the vacuum mixer, add 25 grams of glycerin and stir to form a thick paste liquid, then add 4 grams of azone, 0.2 grams of eucalyptus oil gram, 5 grams of castor oil, and 0.4 grams of aluminum glycylate are mixed evenly; 1.2 grams of polyvinyl alcohol, 0.6 grams of cross-linked polyvinylpyrrolidone, 0.3 grams of sodium carboxymethyl cellulose, 2 grams of tartaric acid, and disodium edetate Add an appropriate amount of purified water to 0.3 g to disperse and dissolve evenly, slowly add to the above glycerin solution, stir evenly to obtain 100 g of viscous colloid, which is coated and pressed into shape.

[0034]Take the SD mouse skin and fix it between the supply pool and the receiving pool of the transdermal device, so that the cuticle faces the supply pool, put in 0.9% saline receiving solution, and drain the air bubbles in the receiving pool so that t...

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PUM

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Abstract

The invention discloses a smoking-quitting hydrogel patch and a preparation method thereof. The smoking-quitting hydrogel patch is prepared by preparing nicotine, polyacrylic acid and sodium polyacrylate copolymer, dihydroxyaluminum aminoacetate, tartaric acid, glycerin, high-molecular polymer having linear and / or netty crosslinking structure, ethylene diamine tetraacetic acid disodium, azone, eucalyptus oil, castor oil and purified water into hydrogel; subjecting the hydrogel to coating, film covering and curing to obtain the smoking-quitting hydrogel patch. The objective of storing and releasing nicotine is achieved by utilizing special structure and ingredients inside materials so as to realize smoking quitting effect. The smoking-quitting hydrogel patch has the advantages of quickness and continuity in release, moisture preservation, air breathability, high skin permeability, little irritation, stability, attractive appearance and comfort.

Description

technical field [0001] The invention relates to a transdermal drug delivery patch for nicotine and a preparation method thereof. Background technique [0002] Nicotine is a major alkaloid that exists in large quantities in tobacco. Although it is neither a carcinogen nor an auxiliary carcinogen, it is the main addictive component of tobacco and has strong addictive properties. Smokers who quit smoking have strong Relapse tendency. Therefore, the effective method of medical smoking cessation treatment is to replace the nicotine obtained from smoking with drugs containing nicotine. The World Health Organization advocated and recommended the use of nicotine replacement therapy to countries in 1996, which can nearly double the success rate of smoking cessation (Nielsen SS, Gallagher LG, et al. Environmental tobacco smoke and Parkinsondisease. MovDisord, 2012, 27 (2): 293-297). [0003] The main therapeutic principle of nicotine replacement therapy is to provide part of the ni...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/36A61K31/465A61P25/34
Inventor 朱颐申刁永勤屠春燕李艳华
Owner NANJING TECH UNIV
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