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Anti-inebriation preparation containing dihydromyricetin and use thereof

A technology of dihydromyricetin and preparations, which is applied in the fields of food and medicine, and can solve problems such as difficulty in controlling the effective dose, complicated components of traditional Chinese medicine compound, and difficulty in clarifying the components.

Inactive Publication Date: 2017-03-15
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the anti-alcoholic medicines in China are traditional Chinese medicine compound prescriptions. The ingredients of traditional Chinese medicine compound prescriptions are complex. It is difficult to clarify the specific components that play a role, and it is difficult to control the effective dose.

Method used

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  • Anti-inebriation preparation containing dihydromyricetin and use thereof
  • Anti-inebriation preparation containing dihydromyricetin and use thereof
  • Anti-inebriation preparation containing dihydromyricetin and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Dihydromyricetin anti-drunkenness and shortening the time of sobering up

[0055] Select SPF grade BALB / C mice (body weight 20-24g) to carry out gavage experiment, the method is as follows:

[0056]Prepare 50% ethanol (EOH:PBS=1:1) and divide it into two groups, with 5-6 animals in each group: (1) EOH group, i.e. gavage with 50% ethanol; (2) EOH+DHM group, i.e. With 50% ethanol aqueous solution as solvent, dihydromyricetin was added to a final concentration of 5 mM. Two groups of animals were given 200ul solution orally respectively.

[0057] The test results were recorded in the following manner, and the percentage of drunken individuals, the latent period of drunkenness, and the drunken period of the two groups of animals were calculated and counted.

[0058] When the righting reflex (repeated many times) disappeared, the time point was recorded as the time point of drunkenness; when the righting reflex reappeared, the time point was recorded as the time point of so...

Embodiment 2

[0067] Dihydromyricetin in high-dose anti-drunkness and reduce death due to drunkenness test

[0068] In the method, the animals and reagents are the same as in Example 1, the solution dose is 300ul, and the percentage of drunk individuals and the percentage of dead individuals are observed.

[0069] see results Figure 4 and 5 shown.

[0070] Figure 4 Among them, dihydromyricetin can reduce the percentage of drunk individuals at high doses. The percentage of drunken individuals in the control group was 100%, while that of the dihydromyricetin test group was only about 60%.

[0071] Figure 5 Among them, dihydromyricetin reduced the percentage of individuals who died at high doses. In the control group, the percentage of drunken dead individuals was 17%, while that of the dihydromyricetin test group was only about 0.

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Abstract

The invention provides an anti-inebriation preparation containing dihydromyricetin and a use thereof. The anti-inebriation preparation containing dihydromyricetin is prepared from dihydromyricetin and an acceptable carrier, and can be processed for form an oral preparation, an injection or other administration-form preparations. The preparation utilizes dihydromyricetin as an active ingredient, is used to prevent inebriation and dispel the effects of alcohol through taking before or after drinking and has the advantages of safety, low toxicity, fast curative effect and few side effects.

Description

technical field [0001] The invention relates to the fields of food and medicine, more specifically to an anti-drunk preparation containing dihydromyricetin and its application. Background technique [0002] In China, drinking is an essential behavior for life, work, and social interaction. Therefore, drunkenness is very common in China. People vary greatly in their tolerance to ethanol, which is due to differences in nerve sensitivity to ethanol, gastrointestinal absorption capacity, and liver metabolic processing capacity. The social and physical harm caused by drunkenness has been widely recognized. According to reports, there are more than 500 million drinkers in China, who cannot avoid drinking in social communication, work entertainment, etc. Among them, 60% of the drinkers drink unhealthily and drink too much; 50% of the drinkers are in sub-health and poor health. below its level. Therefore, drunkenness often occurs, and the problem of hangover also arises from it. ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P25/32A23L33/00
Inventor 季红斌杨柳
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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