Freeze dryer on-line cleaning and sterilization system and method

Abstract

The invention provides a freeze dryer on-line cleaning and sterilization system including a controller, a freeze-drying box and a condensation box; a freeze-drying box inlet and a condensation box inlet are both connected with an inlet pipeline, an inlet group of the inlet pipeline is provided with an inlet master valve, a steam port is provided with a steam valve, a water inlet is provided with a water inlet valve, an air inlet is provided with an air valve, and a compressed air inlet is provided with a compressed air valve; the freeze-drying box is provided with a freeze-drying box drainage and exhaust port, and the freeze-drying box drainage and exhaust port is provided with a first drainage and exhaust valve; the condensation box is provided with a condensation box drainage and exhaust port, and the condensation box drainage and exhaust port is provided with a second drainage and exhaust valve; the freeze-drying box drainage and exhaust port and the condensation box drainage and exhaust port are both connected with a drainage and exhaust pipeline. The system adopts a cleaning and sterilization method, can realize the on-line cleaning and on-line sterilization of a freeze dryer, also has shorter cooling time than that of the prior art, and realizes the convenience of production. The purposes of saving energy and reducing consumption are achieved.

Description

technical field [0001] The invention relates to the technical field of production of biological products and blood products, in particular to an online cleaning and sterilization system and method for a freeze dryer. Background technique [0002] In the technical field of production of biological products and blood products, in order to ensure that the main components in the products, such as proteins and microorganisms, do not denature or lose their biological activity, and maintain their original properties, most of the products are usually freeze-dried. Before each freeze-drying, the freeze-drying box, condensation box and related shelves and pipes of the freeze-dryer need to be washed with 80°C high-temperature water for injection to ensure the cleaning effect of the reaction tank and pipes. After the online cleaning is completed, pure steam is required to sterilize the freeze-drying box, condensation box and related shelves and pipelines of the freeze dryer to ensure th...

AI Technical Summary

Problems solved by technology

The above method has the following problems: 1) If natural cooling is performed after on-line sterilization, since the freeze dryer box and pipelines have insulation layers, the cooling time will be too long, which will affect the arrangement of the production process; 2) Most freeze dryers now use After in-line sterilization, cool down to a certain temperature naturally, turn on the compressor and circulation pump, and use the cooled silicone oil to cool down the shelf

Although this method can achieve rapid cooling of the freeze-drying machine to a certain extent, it consumes a lot of energy; 3) The design of the water-cooled jacket not only wastes water resources, but also cannot achieve uniform cooling of the components of the freeze-drying box. And if the jacket leaks, there is a risk of product contamination

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