Antibacterial soluble hemostatic material and preparation method thereof

A hemostatic material and soluble technology, applied in the field of medical devices, can solve the problem of no antibacterial function, and achieve excellent hemostatic effect, good biocompatibility, and no toxic and side effects.

Inactive Publication Date: 2017-03-15
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the existing soluble hemostatic materials have the characteristics

Method used

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  • Antibacterial soluble hemostatic material and preparation method thereof

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Embodiment 1

[0026] An antibacterial and soluble hemostatic material, prepared by acupuncture process of sodium carboxymethyl cellulose fiber and carboxymethyl chitosan fiber, the mass ratio of sodium carboxymethyl cellulose fiber and carboxymethyl chitosan fiber is 7:3.

[0027] The preparation method of the hemostatic material comprises the following steps:

[0028] (1) Pretreat the medical absorbent cotton fibers with absolute ethanol for 30 minutes;

[0029] (2) After the pretreatment, soak the medical absorbent cotton fibers in a mixed solution of ethanol and alkali (25wt%) (v / v=1:1) for alkalization at 30°C for 30 minutes;

[0030] (3) After the alkalization reaction is completed, add chloroacetic acid ethanol solution (acid-base ratio: 3:1) to the reaction system, react at 30°C for 30 minutes, raise the temperature to 70°C, and react for 2.5 hours;

[0031] (4) After the reaction, adjust the pH to 7 with a mixed solution of acetic acid ethanol (V / V=1:4), then wash with 80% ethanol...

Embodiment 2

[0037] An antibacterial and soluble hemostatic material, prepared by acupuncture process of sodium carboxymethyl cellulose fiber and carboxymethyl chitosan fiber, the mass ratio of sodium carboxymethyl cellulose fiber and carboxymethyl chitosan fiber is 7:3.

[0038] (1) Pretreat the medical absorbent cotton fiber for 30 minutes with absolute ethanol;

[0039] (2) After the pretreatment, soak the medical absorbent cotton fibers in a mixed solution of ethanol and alkali (25wt%) (v / v=1:1) for alkalization at 30°C for 30 minutes;

[0040] (3) After the alkalization reaction is completed, add chloroacetic acid ethanol solution (acid-base ratio: 4:1) to the reaction system, react at 30°C for 30 minutes, raise the temperature to 70°C, and react for 2.5 hours;

[0041] (4) After the reaction, adjust the pH to 7 with a mixed solution of acetic acid ethanol (V / V=1:4), then wash with 80% ethanol aqueous solution for 3 times, and finally obtain sodium carboxymethylcellulose fiber by fre...

Embodiment 3

[0047] An antibacterial and soluble hemostatic material, prepared by acupuncture process of sodium carboxymethyl cellulose fiber and carboxymethyl chitosan fiber, the mass ratio of sodium carboxymethyl cellulose fiber and carboxymethyl chitosan fiber is 7:3.

[0048] (1) Pretreat the medical absorbent cotton fibers with absolute ethanol for 30 minutes;

[0049] (2) After the pretreatment, soak the medical absorbent cotton fibers in a mixed solution of ethanol and alkali (30wt%) (v / v=1:1) for alkalization at 30°C for 30 minutes;

[0050] (3) After the alkalization reaction is completed, add chloroacetic acid ethanol solution (acid-base ratio: 3:1) to the reaction system, react at 30°C for 30 minutes, raise the temperature to 70°C, and react for 2.5 hours;

[0051] (4) After the reaction, adjust the pH to 7 with a mixed solution of acetic acid ethanol (V / V=1:4), then wash with 80% ethanol aqueous solution for 3 times, and finally obtain sodium carboxymethylcellulose fiber by fr...

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Abstract

The invention discloses an antibacterial soluble hemostatic material and a preparation method thereof. The antibacterial soluble hemostatic material is characterized in that firstly modified treatments such as alkalization, etherification, neutralization and alcohol leaching are carried out on medical degreasing cotton fiber to obtain sodium carboxymethylcellulose fiber, then carboxymethylation modification is carried out on chitosan fiber to obtain carboxymethyl chitosan fiber, and finally a needle punching technology is carried out on the sodium carboxymethylcellulose fiber and the carboxymethyl chitosan fiber to obtain the antibacterial soluble hemostatic material. The component of the hemostatic material prepared in the invention is a macromolecule natural material, the hemostatic material has excellent antibacterial performance while having a double-hemostasis function, hemostasis and inflammation diminishment can be realized quickly without adding any medicine, surgical adhesions can also be prevented, and finally the product is decomposed into monosaccharide in the body and absorbed by the human body without toxic or side effects.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an antibacterial soluble hemostatic material and a preparation method thereof. Background technique [0002] According to statistics, the main cause of death on the battlefield is excessive blood loss, accounting for about 50% of the total, while in peacetime, 39% of people who died due to trauma died from excessive blood loss. Hemorrhage that has not been effectively controlled is already The second leading cause of traumatic death. Even if the bleeding can be gradually controlled over a long period of time, excessive blood loss usually leads to serious consequences such as wound infection, hypothermia, coagulopathy or multiple organ failure. [0003] Soluble hemostatic material is a new type of hemostatic material that has developed well in recent years. The soluble hemostatic material can quickly stop bleeding and is non-toxic and has no side effects. It is easy to use and is s...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/46
CPCA61L15/28A61L15/46A61L2300/232A61L2300/404A61L2400/04C08L1/286C08L5/08
Inventor 卢亢韦加娜陈锦涛吴帅
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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