Mitochondrion 3,4,9,10-perylenetetracarboxylic dianhydride targeting fluorescent probe and application thereof

Abstract

The invention discloses a mitochondrion 3,4,9,10-perylenetetracarboxylic dianhydride targeting fluorescent probe and an application thereof. The molecular formula of the mitochondrion 3,4,9,10-perylenetetracarboxylic dianhydride targeting fluorescent probe is C104H108Br2N4O18P2, and the molar mass of the fluorescent probe is 1923.74. The mitochondrion 3,4,9,10-perylenetetracarboxylic dianhydride targeting fluorescent probe is characterized in that two sides of a fluorophore 3,4,9,10-perylenetetracarboxylic diimide are connected with two water-soluble PEO chains, and the hydrophilicity of the probe is improved greatly; by means of presence of a linking group, the whole conjugate plane is enlarged, and the fluorescence property of the probe is improved; a triphenylphosphine cation is introduced to the position of the linking group, so that the linking group serving as a targeting group can be specifically bound to the mitochondrion. The invention further provides the application of the mitochondrion 3,4,9,10-perylenetetracarboxylic dianhydride targeting fluorescent probe in living cell imaging and provides an application method of the mitochondrion 3,4,9,10-perylenetetracarboxylic dianhydride targeting fluorescent probe. Experiments prove that the fluorescent probe enters cells easily, is good in cell uploading rate and good in cell permeability and cannot produce cytotoxicity.

Description

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AI Technical Summary

Benefits of technology

In this patented technology, it uses polyethyleneglycols (PEG) with specific chemical groups attached onto their ends or terminal end to create polymers called polypolyether gels (PPG). These molecules have unique properties such as being able to attach drugs directly into biological tissues without damaging them during manufacturing processes while also making sure they are safe from harmful substances released when injected inside humans' bodies. They help deliver these medications more efficiently through various routes like injection, absorption through skin layers, etc., resulting in better patient outcomes.

Problems solved by technology

Technological Problem addressed in this patented text relates to improving the choice and optimal design of fluorophore probe moleculae used during fluoresceimaging analysis due to their ability to absorb light efficiently without being affected by environmental factors such as temperature and humidity. Current methods involve modifying certain parts of the molecules themselves but they may also affect some important ones like photosensitizers' efficiency. Therefore there is a technical problem how to optimize these modifications while maintaining good optoelectronic property and biocompatibility.

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