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Chemical synthesis method of palmitoyl coenzyme A potassium salt

A palmitoyl coenzyme and chemical synthesis technology, applied in the field of chemical synthesis, can solve the problems of expensive raw materials, inconvenient implementation, large-scale production, and complicated processes, and achieve the effects of cheap raw materials, favorable large-scale production, and simple processes

Active Publication Date: 2019-03-08
BEIJING LEADMAN BIOCHEM
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  • Application Information

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Problems solved by technology

[0008] For the existing chemical synthesis method of palmitoyl-CoA potassium salt, the raw materials are expensive, the process is complicated, and it is not convenient for implementation and large-scale production

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  • Chemical synthesis method of palmitoyl coenzyme A potassium salt
  • Chemical synthesis method of palmitoyl coenzyme A potassium salt
  • Chemical synthesis method of palmitoyl coenzyme A potassium salt

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Embodiment Construction

[0020] The technical solutions of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0021] The chemical synthesis method of the palmitoyl-CoA potassium salt shown in the examples includes the following steps: S1, the synthesis of palmitic anhydride: reacting palmitic acid and acetic anhydride, the reaction system is a yellow transparent solution, and the temperature is cooled to room temperature. Then rotary evaporation removes excess acetic anhydride to obtain a white solid, which is palmitic anhydride; S2, synthesis of palmitic acid dimethylaminoethylmercapto: the prepar...

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Abstract

The invention provides a chemical synthesization method of a palmitoyl coenzyme A potassium salt (palmityl-CoA). The chemical synthesization method comprises the following steps that S1, synthesization of palmitic anhydride; S2, synthesization of palmitic dimethylamino mercaptoethyl; S3, synthesization of palmitic trimethylamine mercaptoethyl iodide; and S4, synthesization of the palmityl-CoA. According to the chemical synthesization method of the palmityl-CoA, by introducing a sulfydryl-ester replacement reaction, side reactions are effectively reduced, only four steps of the chemical reactions are needed, the palmityl-CoA product with the purity being 95% can be obtained after being subjected to one-step purification, and the chemical synthesization method is cheap in raw material, simple in process and convenient to implement, and facilitates mass production.

Description

technical field [0001] The invention relates to a chemical synthesis method, in particular to a chemical synthesis method of palmitoyl-CoA potassium salt. Background technique [0002] Palmitoyl Coenzyme A Potassium salt (Palmitoyl Coenzyme A Potassium salt, referred to as: Palmityl-CoA) is a special biochemical reagent, mainly used for the determination of acetyl-CoA oxidase activity, the reaction principle is as follows: [0003] [0004] There are many documents about the preparation of this compound. To summarize, there are the following: 1. Biological enzymatic preparation, such as Chinese patent CN103074400B mentioning a method for preparing palmitoyl-CoA by a biological fermentation method. The advantage of this method is that it is greatly The manufacturing cost is reduced, but the disadvantages are also obvious. The purity of the obtained product is only 40-50%, and the follow-up purification process is very complicated, which limits the improvement of product qu...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H19/20C07H1/00
CPCC07H1/00C07H19/20
Inventor 张建伟梁艳伟谷彦霞于飞熊宁叶建峰
Owner BEIJING LEADMAN BIOCHEM