New uses of semen persicae

A technology of peach kernels and uses, which is applied in the field of medicine, can solve the problem of not finding tumor neovascularization, etc., and achieve a significant effect and the effect of inhibiting tumor neovascularization

Inactive Publication Date: 2017-04-19
钟森 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Although it has also been reported that it has anti-tumor effects, it has not been found to inhibit tumor angiogenesis

Method used

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  • New uses of semen persicae
  • New uses of semen persicae
  • New uses of semen persicae

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Experimental program
Comparison scheme
Effect test

Embodiment

[0043] 1. Materials and methods

[0044] 1.1 Material

[0045] Chinese medicines were purchased from Sichuan Huichuntang Pharmaceutical Co., Ltd. All reagents were purchased from Sigma-Aldrich Co. (St. Louis, MO), and PTK787 (vatalanib) was purchased from Selleckchem. Fli1a-EGFP transgenic zebrafish was used for experiments. Zebrafish are reared in a standard environment.

[0046] 1.2 Reagent preparation

[0047] Weigh 450g of traditional Chinese medicine, decoct in 8 times the amount of water for 3 times, 1 hour each time, combine the 3 times of decoction on an 800W electric furnace and concentrate to about 400ml, pass through a 100-mesh sieve (filter residue sample), and apply evenly In the evaporating dish, place the evaporating dish in an electric heating blast drying oven, and after intermittent drying at 60°C for 62 hours, continue to dry in a glass desiccator at room temperature until the moisture content is reached <5% (determined by drying method) of extract.

[0048] 1.3 E...

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PUM

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Abstract

The present invention discloses new uses of semen persicae, particularly uses of semen persicae or boiling-water-soaked semen persicae or fried semen persicae in tumor angiogenesis inhibition drugs, wherein an effective dose of the semen persicae or boiling-water-soaked semen persicae or fried semen persicae is adopted as an active component and is added with a pharmaceutically acceptable auxiliary material according to a conventional pharmacy method to prepare the agent, ie., the tumor angiogenesis inhibition drug. According to the present invention, the semen persicae or boiling-water-soaked semen persicae or fried semen persicae is applied in the tumor angiogenesis inhibition, such that the tumor growth can be effectively inhibited, the good medicinal value is provided, and the new selection is provided for the clinic.

Description

Technical field [0001] The invention belongs to the field of medicine, and specifically relates to new uses of peach kernels, especially peach kernels or Use of peach kernels or fried peach kernels in preparing drugs for inhibiting tumor angiogenesis. Background technique [0002] Angiogenesis is the process of sprouting from existing blood vessels to generate new blood vessels. This process is related to the migration and proliferation of vascular endothelial cells. The embryonic development process is accompanied by angiogenesis. But apart from wound healing, female menstruation and some pathological processes (such as cancer), angiogenesis rarely occurs in adults. [0003] Angiogenesis is extremely important for the growth, metastasis and prognosis of malignant solid tumors. Angiogenesis is necessary for the further growth of malignant solid tumors after breaking through the epithelial basement membrane. The newly formed blood vessels in tumors have their own unique structu...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61P35/00A61K131/00
Inventor 钟森涂翔
Owner 钟森
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