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Biological 3D printing planting shell wire rod and formula and manufacturing process thereof

A 3D printing and manufacturing process technology, applied in the field of biological 3D printing, can solve the problems of easy breeding of bacteria, inability to confirm the shell, etc., and achieve the effects of convenient measurement, improved plasticity, increased viscosity and hardness

Inactive Publication Date: 2017-04-26
GUANGXI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the defects in the prior art that the content of the shell in the planting organ cannot be determined in the biological 3D printing cell planting shell wire material and the bacteria are easy to breed, the pre

Method used

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  • Biological 3D printing planting shell wire rod and formula and manufacturing process thereof
  • Biological 3D printing planting shell wire rod and formula and manufacturing process thereof
  • Biological 3D printing planting shell wire rod and formula and manufacturing process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041]A formulation of biological 3D printing planting shell wire, comprising the following substances by weight: 12 parts of phenazine derivative gel factor, 20 parts of pectin, 30 parts of chitosan gel, 10 parts of collagen, 0.9 wt% chlorine 18 parts of sodium chloride solution, 8 parts of amylose, 5 parts of polystyrene sulfonate, 10 parts of sterilized natural silk powder, 12 parts of ethanol, and 40 parts of water.

[0042] The manufacturing process of the biological 3D printing planting shell wire comprises the following steps:

[0043] (1) Add pectin, chitosan gel and collagen to the heating mixer, then add water to the mixer, heat and stir until dissolved, keep warm at 95-100°C for 30-60min, and then gradually cool down to 75°C ~85°C;

[0044] (2) Add chitosan into the mixing system of step (1), stir until dissolved at 75-85° C., and keep warm for 5-10 minutes;

[0045] (3) Heat and dissolve the phenazine derivative factor in ethanol under airtight conditions to form...

Embodiment 2

[0048] Embodiment 2: A formula for bio-3D printing planting shell wire, including the following materials in parts by weight: 10 parts of phenazine derivative gel factor, 20 parts of sodium alginate gel, 40 parts of gelatin, 8 parts of collagen, 15 parts of crystal sugar, 10 parts of mannitol, 8 parts of sterilized natural silk powder, 15 parts of ethanol, and 40 parts of water.

[0049] The manufacturing process of the biological 3D printing planting shell wire comprises the following steps:

[0050] (1) Add 20 parts of sodium alginate gel, gelatin and collagen to a heating mixer, then add water to the mixer, heat and stir until dissolved, keep warm at 95-100°C for 30-60 minutes, and then gradually cool down to 75~85℃;

[0051] (2) Add chitosan into the mixing system of step (1), stir until dissolved at 75-85° C., and keep warm for 5-10 minutes;

[0052] (3) heating and dissolving the phenazine derivative factor in a mixed solution of isopropanol and ethanol under airtight ...

Embodiment 3

[0055] Embodiment 3: A formula for bio-3D printing planting shell wire, including the following materials in parts by weight: 18 parts of phenazine derivative gel factor, 42 parts of agar, 10 parts of collagen, and 15 parts of 0.9wt% sodium chloride solution , 5 parts of monocrystalline sugar, 15 parts of chitin, 12 parts of sterilized natural silk powder, 10 parts of ethanol, and 50 parts of water.

[0056] The manufacturing process of the biological 3D printing planting shell wire comprises the following steps:

[0057] (1) Add agar and collagen to the heating mixer, then add water to the mixer, heat and stir until dissolved, keep warm at 95-100°C for 30-60min, and then gradually cool down to 75-85°C;

[0058] (2) Add chitosan into the mixing system of step (1), stir until dissolved at 75-85° C., and keep warm for 5-10 minutes;

[0059] (3) heating and dissolving the phenazine derivative factor in acetone under airtight conditions to form a solution with a concentration of ...

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Abstract

The invention discloses a biological 3D printing planting shell wire rod and a formula and manufacturing process thereof and belongs to the technical field of biological 3D printing, the biological 3D printing planting shell wire rod is prepared from phenazine derivative gel, natural gel, collagen, cell nutrients, hydrophilic additives, sterilized natural silk powder, ethyl alcohol and water. The manufacturing process includes the following steps: firstly heating and dissolving the natural gel and the collagen, then adding the chitosan, dissolving the chitosan while stirring the mixture, adding the phenazine derivative gel, the hydrophilic additives, the sterilized natural silk powder, the cell nutrients and the ethyl alcohol in the mixed system, mixing the mixture evenly and fully, evaporating a solvent, and finally conducting extrusion molding to obtain the shell wire rod. The biological 3D printing planting shell wire rod has the advantages that the content is measurable, the measurement is convenient, sterilization of the system can be conducted on the premise that normal cells are not damaged, and the safety is high.

Description

technical field [0001] The present invention relates to the technical field of biological 3D printing, and more specifically, relates to a biological 3D printing planting shell wire material and its formula and production process. Background technique [0002] 3D printing technology, also known as additive manufacturing technology, is actually a new type of rapid prototyping technology. It is based on digital model files and uses adhesive materials such as powder film metal or plastic to print layer by layer The technology of constructing objects by means of layered manufacturing is based on the technology of adding materials layer by layer to generate three-dimensional solids. [0003] Bio-3D printing is a method that can position and assemble biological materials or cell units according to the principle of additive manufacturing under the drive of digital three-dimensional model, and manufacture medical devices, tissue engineering scaffolds, tissues and organs and other pr...

Claims

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Application Information

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IPC IPC(8): C08L5/08C08L5/06C08L89/00C08L3/12C08L25/18C08L5/04C08L5/12C08L5/02C08L71/02C08K5/3465C08K3/16C08K5/053B33Y70/00B33Y80/00
CPCC08L5/08B33Y70/00B33Y80/00C08L5/12C08L89/00C08L2203/02C08L2205/02C08L2205/025C08L2205/035C08L2205/16C08L5/06C08L3/12C08L25/18C08K5/3465C08K3/16C08L5/04C08K5/053C08L5/02C08L71/02
Inventor 赵劲民郑立陆真慧蒋童蒙黄贤元
Owner GUANGXI MEDICAL UNIVERSITY