Short peptide blocking long-term synaptic potentiation (LTP) and application thereof

A technology of long-term enhancement and short peptides, which is applied in the field of biomedicine to achieve high specificity, wide application prospects, and increased applicability and application range.
CN106632601AActive Publication Date: 2017-05-10KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
Publication Date
2017-05-10

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Abstract

The invention discloses a short peptide blocking long-term synaptic potentiation (LTP) and application thereof and belongs to the field of biological chemistry. A bioinformatics method is adopted to analyze human homologous sequences of different species of AMPA receptor subunits GluR2, it is found that a high conserved domain exists at the terminal C of GluR2, and the short peptide is designed on the basis and further comprises a short peptide modification peptide having cytomembrane penetrating capacity and a short peptide modification peptide marked with a fluorescent group. Amino acid sequences of the short peptide are shown as SEQ ID NO.1 and SEQ ID NO.2. The short peptide or the short peptide modification peptide can block LTP expression and has no influence on functions of LTD and NMDA receptors having synaptic plasticity. Therefore, the short peptide or the short peptide modification peptide is applied to preparation of drugs for treating or preventing diseases related to glutamic acid overexcitation diseases and pathological synaptic plasticity LTP, or establishment of experimental animal models of the diseases related to glutamic acid overexcitation diseases and the pathological synaptic plasticity LTP.
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Description

technical field

[0001] The invention discloses a short peptide for blocking synaptic long-term potentiation (LTP) and its application, especially the application in the field of biomedicine, which belongs to the field of biochemistry. Background technique

[0002] The presynaptic membrane of nerve cells releases neurotransmitters, which act on the receptors of the postsynaptic membrane of nerve cells to form synaptic information transmission between nerve cells. The plasticity of synaptic information transmission endows the plasticity of brain function and structure, which is the fundamental basis of almost all higher brain functions. According to the neurotransmitter, synapses can be divided into excitatory synapses and inhibitory synapses. Glutamate is an excitatory neurotransmitter, and its ionotropic receptors mainly include NMDA (N-methyl-D-aspartic acid receptor, N-methyl-D-aspartic acid receptor) and AMPA receptor (Ξ±- Amino-3-hydroxy-5-methyl-4-isoxazole propionic a...

Claims

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