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Device and method for recording living body fluorescence signals

A living fluorescence and recording device technology, applied in measurement devices, fluorescence/phosphorescence, material analysis through optical means, etc., can solve the problems of reducing experimental efficiency, waste, increasing workload, etc., and achieves a wide range of applications and low cost Effect

Pending Publication Date: 2017-05-24
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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  • Abstract
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Problems solved by technology

In this way, the animals cannot be killed in advance to test whether the virus transfection is successful, and only continue to complete all experiments before testing
This will waste a lot of increased workload and reduce experimental efficiency

Method used

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  • Device and method for recording living body fluorescence signals
  • Device and method for recording living body fluorescence signals

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Embodiment Construction

[0014] Such as figure 1 As shown, the living body fluorescent signal recording device in this embodiment includes two parts: a light source and a detection device. The light source part includes a laser transmitter and a transmission fiber. The end of the transmission fiber is connected to the insertion fiber. The insertion fiber is a light bundle wrapped in stainless steel. Some of the fibers are used for the projection of excitation light, and the rest are used for sampling and collecting fluorescence. Signal. The detection device includes a filter device (filter group), a spectrometer and transmission fiber.

[0015] The optical filter device used in the present invention includes a light shield, and an optical filter stuck on the optical filter groove, connected to the SMA interface of the device, and the optical filter can be replaced at any time. Both ends of the device are connected with optical fibers. After the fluorescence emitted from the monkey brain passes throu...

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Abstract

The invention discloses a device and method for recording living body fluorescence signals. The device comprises a light source and a detection device. The light source comprises a laser transmitter and a transmission optical fiber. The tail end of the transmission optical fiber is connected with an insertion optical fiber, the insertion optical fiber is a light beam with a casing wrapped with stainless steel, part of optical fiber is used for exciting light projection, and the remaining optical fiber is used for sampling and collecting the fluorescence signals. The detection device comprises a light filtering device (an optical filter group), a spectrometer and a transmission optical fiber. Monkey brain viruses can be monitored in real time through the fluorescence signals, experimental efficiency is improved, and manpower and material resources are saved. In addition, the device is simple to operate and low in cost and can detect deep fluorescence signals in brains of different living body animals.

Description

technical field [0001] The invention belongs to the central nervous system living body fluorescent signal recording in the technical field of biological visible light imaging, and in particular relates to a living body fluorescent signal recording device and method. Background technique [0002] With the rise of gene technology, a series of emerging technologies such as optogenetics, retrovirus tracer, gene knockout and gene therapy play an important role in neuroscience research. The realization of all these technologies depends on the injection of different carrier viruses into the target organs, and whether these viruses can successfully transfect the target cells often becomes the key to the success or failure of the experimental operation. Usually, we use fluorescent signals to detect whether the virus has transfected the target cells, whether it is working normally in the experimental animal body, and the extent of the infected tissue. In the past fluorescent signal d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64
CPCG01N21/6402G01N21/6486
Inventor 吴诗昊雷小光何欢谭恒李浩张琳恒胡新天
Owner KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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