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Application of atractylodin in pharmacy

A technique of atractylodes and medicine, applied in the field of medicine

Inactive Publication Date: 2017-05-31
泰州中国医药城中医药研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report about the positive inotropic activity of atractylodes

Method used

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  • Application of atractylodin in pharmacy
  • Application of atractylodin in pharmacy
  • Application of atractylodin in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Method:

[0028] Healthy and clean male SD rats with a body weight of 250-300 grams were anesthetized by intraperitoneal administration of 20% urethane 5 mL / kg. Using the Langendorff apparatus, oxygenation (95% O 2 +5%CO 2 ) conditions, isolated heart perfusion (mmol / L): NaCl117, KCl5.7, CaCl 2 1.8,MgCl 2 1.7,NaHCO 3 4.4, NaH 2 PO 4 1.5, HEPES 20, Glucose 11, adjust the pH to 7.4 with NaOH, and the temperature is (37.5±0.5)°C. The baroreceptor probe was inserted into the left ventricle through the left atrium, and connected to the biological amplifier through the pressure transducer to record the contraction curve of the left ventricle. The order of cardiac perfusion is: normal perfusate (Control) → perfusate containing atractylodes (1 μmol / L) → perfusate containing atractylodes (10 μmol / L) → normal perfusate washout (Washout), each group of perfusate perfused for 5 minutes Then start to record the shrinkage curve. The recorded indicators include heart r...

Embodiment 2

[0034] 1. Instrument

[0035] PowerLab multiconductor physiological recorder (Australia AD Instruments, model PowerLab8 / 35); Millar amplifier (US MILLAR company, model: 735-2083Rev.F); Millar ventricular pressure and pressure volume catheter (model: SPR-901)

[0036] 2. Method:

[0037] Healthy clean male SD rats with a body weight of 250-300 grams were anesthetized by intraperitoneal administration of 20% urethane 5ml / kg. Under anesthesia, the right common carotid artery and the left external jugular vein were separated, and the pressure of the pressure-volume catheter was calibrated. Atractylodin (5 mg / kg) was first dissolved in 0.1 mL of DMSO, then added with normal saline to 1 mL, injected slowly through the left external jugular vein, and the effect of Atractylodin was continuously recorded for 30 min. After the experiment, the volume was calibrated with 30% (g / 100mL) saline and autologous blood. The experimental results were analyzed with the Labchart 8 software of AD...

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PUM

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Abstract

The invention discloses application of atractylodin in the preparation of drugs for treating and preventing heart failure, and belongs to the field of medicine. Atractylodin can significantly increase maximum rising speed of left ventricular developed pressure and left ventricular pressure of rat isolated heart, is dependent on concentration, causes no significant effect on heart rate, and is free of adverse effect causing arrhythmia. It is indicated that atractylodin has positive inotropic action and is not dependent on neurohumor. Atractylodin can significantly increase a normal rat's end-systolic volume, end-systolic pressure, stroke volume, ejection fraction, cardiac output, left ventricular pressure maximum rising speed, stroke work, and slope of end-systolic pressure-volume relational curve. It is indicated that atractylodin has positive inotropic action without increasing heart rate.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the application of atractylodes atractylodis in pharmacy, in particular to the application of atractylodes atractylodis in the preparation of medicines for treating and preventing heart failure. Background technique [0002] Positive inotropes are widely used in the treatment of congestive heart failure, especially when the disease is in the exacerbation stage, it is a very important treatment method to improve myocardial contractile function by positive inotropes. [0003] At present, the commonly used inotropic drugs mainly include: [0004] 1. cAMP-dependent positive inotropes, including: [0005] 1. β-receptor agonists: This class of drugs includes dopamine, dobutamine, and norepinephrine, and is used to improve hemodynamic parameters in the acute exacerbation stage of myocardial dysfunction in patients with heart failure. Treatment of congestive heart failure with beta-agonists is rel...

Claims

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Application Information

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IPC IPC(8): A61K31/341A61P9/04
CPCA61K31/341
Inventor 陈龙
Owner 泰州中国医药城中医药研究院
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