A compensation method for scanning speed mismatch of tdi-cmos fluorescence detection instrument
A technology of scanning speed and fluorescence detection, applied in instruments, scientific instruments, fluorescence/phosphorescence, etc., can solve problems such as blurred images, achieve efficient detection and promote development
Active Publication Date: 2020-06-05
SHANGHAI ADVANCED RES INST CHINESE ACADEMY OF SCI
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Problems solved by technology
[0007] In view of the shortcomings of the prior art described above, the purpose of the present invention is to provide a compensation method for the mismatch of scanning speed of the TDI-CMOS fluorescence detection instrument, which is used to solve the problem caused by the mismatch of scanning speed of the TDI-CMOS fluorescence detection instrument in the prior art. image blurring etc.
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[0030] Embodiments of the present invention are described below through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific implementation modes, and various modifications or changes can be made to the details in this specification based on different viewpoints and applications without departing from the spirit of the present invention.
[0031] see Figure 3 ~ Figure 5 . It should be noted that the diagrams provided in this embodiment are only schematically illustrating the basic idea of the present invention, and only the components related to the present invention are shown in the diagrams rather than the number, shape and shape of the components in actual implementation. Dimensional drawing, the type, quantity and proportion of each component can be changed arbi...
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The invention provides a compensation method for TDI (time delay and integration)-CMOS (complementary metal-oxide semiconductor) fluorescence detection instrument scanning speed mismatch, comprising the steps: arranging a calibration line with a certain length on a biochip, judging whether the scanning speed of a TDI-CMOS fluorescence detection instrument is mismatched or not by judging the scanned length of a calibration line image, and thus adjusting the scanning speed to enable the operation time sequence of the TDI-CMOS fluorescence detection instrument is strictly matched with the scanning speed and scanning amplitude. The compensation method for the TDI-CMOS fluorescence detection instrument scanning speed mismatch can be used for efficiently detecting a weak fluorescence signal in the biochip to form a high-resolution image, thus contributing the development of bioresearch.
Description
technical field [0001] The invention relates to the field of image acquisition, in particular to a compensation method for scanning speed mismatch of a TDI-CMOS fluorescence detection instrument. Background technique [0002] Cancer is the most important threat to human life and health. Every year, more than 12 million people are diagnosed with cancer in the world, and on average, 1 person dies of cancer in every 8 deaths. miRNA is a type of endogenous non-coding small molecule RNA (Ribonucleic Acid, ribonucleic acid) found in eukaryotes, which regulates 30% of human gene functions. Mature miRNA is a single-stranded RNA with an average length of 19-24 nucleotides (nt), its main function is to regulate gene expression at the post-transcriptional level, and participate in a series of life activities, including cell proliferation and apoptosis, organ formation, The process of hematopoiesis and development are closely related to the occurrence, diagnosis, treatment and prognos...
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IPC IPC(8): G01N21/64
CPCG01N21/6408
Inventor 汪辉封松林
Owner SHANGHAI ADVANCED RES INST CHINESE ACADEMY OF SCI