A trace element selenium dietary supplement with the function of relieving Salmonella-induced enteritis

A dietary supplement, Salmonella technology, applied to the functions of food ingredients, antibacterial drugs, baked goods, etc., to achieve the effects of improving antioxidant capacity, improving immunity, and inhibiting infection

Active Publication Date: 2021-03-30
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although only a small number of Salmonella will be resistant to antibiotics (or spontaneous mutations), after the widespread use of antibiotics, these small numbers of bacteria will reproduce in large numbers, become the dominant flora and cause enteritis in the body

Method used

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  • A trace element selenium dietary supplement with the function of relieving Salmonella-induced enteritis
  • A trace element selenium dietary supplement with the function of relieving Salmonella-induced enteritis
  • A trace element selenium dietary supplement with the function of relieving Salmonella-induced enteritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: mouse feed preparation

[0028] Feed preparation method of the present invention such as figure 1 shown.

[0029] Sodium selenite is dissolved in deionized water, then mixed with the feed, and granulated. Weigh 0.15, 0.40, 1.00 and 2.00 mg of sodium selenite respectively, dissolve in 200 mL of deionized water, pour into 1 kg of feed material, mix and granulate. Feeds with selenium content of 0.15, 0.40, 1.00 and 2.00 mg / kg were formed, named as control group, selenium-enriched group, high-selenium group and extremely high-selenium group respectively. They are equivalent to human intake of 50, 200, 400 and 800ug / d. In the enforcement of the present invention, the composition of feed is shown in table 1, table 2 as follows:

[0030] Table 1 Basic Feed Composition and Content

[0031]

[0032] Table 2 Basic Feed Composition and Nutrient Content

[0033]

Embodiment 2

[0034] Example 2: Effects of trace element selenium dietary supplements on tissues of mice infected with Salmonella

[0035] Forty four-week-old SPF mice were randomly divided into 4 groups, 10 in each group. The groups were control group, selenium-enriched group, high-selenium group and extremely high-selenium group. Each group was fed with feeds containing 0.15, 0.40, 1.00 and 2.00 ppm selenium, respectively. The mice had free access to food and water for 2 months. After the end of the two months, all the mice were fasted for 4 hours, and 20 mg of streptomycin was administered through the mouth, and the mice were allowed to eat and drink freely. After being treated with streptomycin for 20 hours, food and water were fasted again for 4 hours. 7 CFU Salmonella typhimurium SL1344. After 48 hours, all the mice were killed and dissected, the spleen and mesenteric lymph nodes (mLN) were washed with normal saline, homogenized in normal saline containing 1% Triton 100, and the ho...

Embodiment 3

[0040] Example 3: Effects of trace element selenium dietary supplements on the antioxidant capacity of mice

[0041] According to the mouse experiment described in Example 1, after the end of the experiment, the mice were sacrificed by taking blood from the eye sockets, and the livers of the mice were washed with pre-cooled physiological saline and homogenized. Determination of antioxidant indicators such as SOD (superoxide dismutase), MDA (malondialdehyde) and T-AOC (total antioxidant capacity) in the liver. The test results are shown in the table below.

[0042] Table 4 Determination of antioxidant activity in mouse liver

[0043]

[0044] Note: * indicates that there is a significant difference between this group and the control group, p<0.05; ** indicates that there is a very significant difference between this group and the control group, p<0.01.

[0045] After Salmonella invades the body, it will secrete endotoxin through its own metabolism and increase the oxidativ...

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PUM

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Abstract

The invention discloses a trace element selenium dietary supplement with a function of relieving salmonella induced enteritis, and belongs to the technical field of food. The trace element selenium dietary supplement provided by the invention has the main beneficial ingredients of sodium selenite; the infection of the salmonella on the mouse immune organs can be inhibited; the mouse body anti-oxidization index can be obviously improved. The trace element selenium dietary supplement provided by the invention is used for preparing medicine compositions, wheat products and fermented milk with the function of relieving salmonella induced enteritis, and has wide application prospects.

Description

technical field [0001] The invention relates to a trace element selenium dietary supplement capable of alleviating enteritis induced by Salmonella, belonging to the technical field of food. Background technique [0002] Salmonella typhimurium is a pathogenic bacterium capable of infecting many mammalian hosts, causing intestinal disease and diarrhea and even death. It is a invasive pathogen without host specificity. It is reported that 40-80% of food poisoning incidents in developed countries such as Japan and the United States are caused by Salmonella infection. In 1981, the World Health Organization announced that there were more than 2,000 species of Salmonella, of which 53-80% were reported in the literature to infect children with typhoid fever. The characteristics of Salmonella typhimurium are: aerobic, non-spore-forming, Gram-negative bacteria with flagella. It has a strong ability to adapt to the outside world and is widely distributed in nature. Common sources of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L33/16A23K20/20A23C9/13A23L7/10A21D13/00A21D2/02A61K33/04A61P31/04
CPCA21D2/02A21D13/00A23C9/1322A23V2002/00A61K33/04A23V2200/30A23V2200/32A23V2250/1626Y02A50/30
Inventor 陈卫田丰伟翟齐啸李鹏赵建新张灏
Owner JIANGNAN UNIV
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