Brain network analysis method for detecting cognitive function improved by blood nourishing and brain clearing pills

Abstract

The invention belongs to the field of neuroimaging and science of Chinese pharmacology, and relates to the field of brain functional network research based on functional magnetic resonance imaging (fMRI) data, in particular to a brain network analysis method for detecting the cognitive function improved by blood nourishing and brain clearing pills. The brain network analysis method for detecting the cognitive function improved by blood nourishing and brain clearing pills comprises the following steps: (1) designing an experiment, taking a sub-health population as a research object by means of resting fMRI experiments; (2) collecting the fMRI data under resting states; (3) preprocessing the collected fMRI data; (4) defining nodes and edges and selecting a threshold; (5) selecting a traditional brain network analysis method to analyze the fMRI data; (6) selecting a frequent subgraph mining method to analyze the fMRI data; (7) analyzing, comparing and integrating the results of the two methods to obtain the neurological mechanism of the cognitive function improved by the blood nourishing and brain clearing pills.

Description

technical field [0001] The invention belongs to the fields of neuroimaging and Chinese pharmacy, relates to the field of brain function network research based on functional magnetic resonance imaging (fMRI) data, and specifically relates to a brain network analysis method for detecting Yangxue Xuenao pills to improve cognitive functions. Background technique [0002] Yangxue Xuenao Pill is a national third-class new traditional Chinese medicine developed and produced by Tianjin Tasly Pharmaceutical Co., Ltd. It is based on the "Siwu Decoction" in the famous Song Dynasty traditional Chinese medicine book "Taiping Huimin Heji Bureau Prescription" and is developed by using the latest technology. The preparation that treats both symptoms and root causes has the effect of "nourishing and activating blood, calming the liver and suppressing yang". Its main ingredients are Angelica, Chuanxiong, Paeoniae Alba, Rehmannia glutinosa, Uncaria, Millae, Prunella, Cassia, Mother of Pearl, C...

AI Technical Summary

Problems solved by technology

In addition to brain functional network analysis, there are functional connectivity methods based on seed points, local consistency analysis, and independent component analysis, but none of these methods can analyze the topological properties of the network.

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