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Kit applied to early diagnosis of Alzheimer disease (AD)

A technology for early diagnosis of Alzheimer's disease, applied in the field of bioengineering, can solve problems such as low accuracy and complicated methods for Alzheimer's disease

Inactive Publication Date: 2017-06-23
SHANGHAI EAST HOSPITAL EAST HOSPITAL TONGJI UNIV SCHOOL OF MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the above technical problems in the prior art, the present invention provides a kit for early diagnosis of Alzheimer's disease, said kit for early diagnosis of Alzheimer's disease should solve the existing The early diagnosis method of Alzheimer's disease in the technology is complex and the technical problem is not high accuracy

Method used

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  • Kit applied to early diagnosis of Alzheimer disease (AD)
  • Kit applied to early diagnosis of Alzheimer disease (AD)
  • Kit applied to early diagnosis of Alzheimer disease (AD)

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Embodiment 1

[0015] 1. Inventors

[0016] Mild Cognitive Impairment (MCI) patients and AD patients included in the present invention were recruited from the Dementia Clinic of Ruijin Hospital Affiliated to Shanghai Jiaotong University by neurologists. Age- and sex-matched healthy controls (HC) were recruited through epidemiological survey community advertisements, or relatives of participants with MCI or AD patients. A total of 150 participants aged 55 and older participated in the two-year observational invention. Each participant underwent standardized evaluations, including medical and neuropsychological evaluations. After obtaining the patient's informed consent, each participant took a peripheral blood sample in a EDTA anticoagulant tube. Patients in the diagnosed MCI group met the criteria for subjective and objective cognitive difficulties without significant loss of function. The diagnosis of AD was based on the National Association for Neurologic and Communication Disorders and...

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Abstract

The invention discloses a kit applied to early diagnosis of Alzheimer disease (AD). The kit contains an epidermal growth factor, a growth regulation alpha protein / C-X-C sequence motif chemotactic factor, a chemotactic factor / C-C sequence motif chemotactic factor 22 derived from macrophage, a monocyte chemoattractant protein 1 / C-C sequence motif chemotactic factor 2, a monocyte chemoattractant protein 2 / C-C sequence motif chemotactic factor 8, a monocyte chemoattractant protein 4 / C-C sequence motif chemotactic factor 13, a thymus and activation-regulated chemotactic factor / C-C sequence motif chemotactic factor 17, a stem cell factor / Kit ligand, a Tumor Necrosis Factor (TNF)-related apoptosis-inducing ligand / tumor necrosis factor ligand superfamily member 10, a skin T cell attraction chemotactic factor / C-C sequence motif chemotactic factor 27 and a gamma-microtubulin compound component 2 biomarker. A model consisting of 11 immune or inflammation-related plasma proteins provided by the invention can be applied to the early diagnosis of the AD.

Description

technical field [0001] The invention belongs to the field of bioengineering, and relates to a diagnostic kit, in particular to a kit for early diagnosis of Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is an insidious onset progressive neurodegenerative disease with the highest incidence in people over 65 years old. According to the invention of the University of Edinburgh, as of 2010, about 5.69 million people in China suffer from AD, compared with 1.93 million in 1990, which has almost tripled in 20 years. With the progress of population aging in our country, it is expected that the proportion of increase in AD will be steeper in the next 20 years, resulting in huge family, social and economic burdens. However, contrary to the rapidly increasing patient population and huge social and economic costs, there is currently no effective means to cure AD. Symptoms of AD develop slowly and gradually worsen over time. Multiple lines of evidence sugg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6896G01N2800/2821
Inventor 赵简丁健青王瑛
Owner SHANGHAI EAST HOSPITAL EAST HOSPITAL TONGJI UNIV SCHOOL OF MEDICINE
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