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A fully automatic biological sample component sorting device

A technology for biological samples and sorting devices, which is applied to the analysis of materials, instruments, etc., to achieve the effects of shortening time, simplifying the process, and omitting elution steps

Active Publication Date: 2019-04-12
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method is not as highly specific as the immune method, and it can be used as a negative sorting method especially in the application of blood component sorting

Method used

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  • A fully automatic biological sample component sorting device
  • A fully automatic biological sample component sorting device
  • A fully automatic biological sample component sorting device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] like figure 1 Shown is a schematic top view of a preferred embodiment of the automatic biological sample component sorting device of the present invention, the sorting device includes a centrifugal platform 1, a reagent storage platform 2, a waste collection platform 3, and a transfer head storage platform 4. Magnetic rod storage platform 5, magnetic rod support frame 6, washing and dyeing rack 7, stirring rod storage platform 8, three-dimensional linear track 9 and linear track 10, the three-dimensional linear track is provided with a magnetic bar transfer part 11-1 and reagent transfer Part 11-2, the magnetic rod transfer part 11-1 and the reagent transfer part 11-2 can move along the track in the three-dimensional space of X-Y-Z, and its moving surface covers the operation plane, and the magnetic rod transfer part 11-1 is responsible for the magnetic rod 12 And the transfer, rotation and moving up and down of stirring bar, linear track 10 is used for the movement of ...

Embodiment 2

[0060] like figure 2 Shown is a top view structure diagram of another preferred embodiment of the fully automatic biological sample component sorting device of the present invention, the device is divided into two main structures with the sliding track in the middle, wherein the left side is the centrifugal area, On the right is the staining and reading area. The device shown in the figure can sort 12 samples at the same time. As can be seen from the figure, the sorting device includes a centrifugal platform 1, a first reagent storage platform 2-1, a second reagent storage platform 2-2, a first waste collection platform 3-1, a second waste collection platform 3-2, The first transfer head storage platform 4-1, the second transfer head storage platform 4-2, the magnetic bar storage platform 5, the magnetic bar support frame 6, the dyeing frame 7, the cleaning frame 8, the three-dimensional linear track 9 and the linear track 10, the first A transfer part 11-1, a second transfe...

Embodiment 3

[0063] This embodiment provides a magnetic rod, the structure of the magnetic rod 11 is as image 3 As shown, it includes an insertion rod 111, a magnetic core 112 and a magnetic sleeve 113. The magnetic sleeve 113 is set on the outside of the insertion rod 111 like a pen cover, and wraps the magnetic core 112 inside it. On the magnetic sleeve 113 A capture window 114 is provided, and the surface of the magnetic core 112 corresponding to the capture window 114 is a magnetic field emitting surface through which the magnetic field can radiate outwards. The other surfaces of the magnetic core 112 do not emit a magnetic field outward, and the other surfaces are all covered with soft magnetic materials. Encapsulation, so that the nano-magnetic particles in the capture reagent are gathered in the capture window 114. After the nano-magnetic particles with the target CTC are captured and collected, only the insertion rod 111 is pulled out from the magnetic sleeve 113 to directly captur...

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PUM

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Abstract

The invention discloses an automatic biological sample component sorting apparatus. The sorting apparatus has the purpose of positive sorting and negative sorting, can realize positive sorting and negative sorting of a biological sample component on an device, the two sorting results can be mutually verified and complementary, so that the more accurate detection result is obtained. The sorting apparatus has reasonable layout and compact structure, realizes positive sorting and negative sorting of a biological sample, and realizes automatic process during whole staining course.

Description

technical field [0001] The invention relates to a fully automatic biological sample component sorting device. Background technique [0002] Biological samples (such as blood, urine, interstitial fluid) usually contain multiple components. In most cases, we hope to collect one or several components for further analysis, especially for some rare components, which must be Further research can only be carried out through separation and enrichment. In the fields of immunology and oncology, peripheral blood samples or cell suspensions of related tissues are often relied on to obtain certain specific cells or proteins for analysis or diagnosis of these samples. [0003] The use of immunological methods to identify and sort target components in samples is currently a commonly used collection method. In positive sorting techniques, antibody labeling can be used to separate desired components (such as cells) from unlabeled or unwanted components; in negative sorting techniques, anti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N35/00G01N35/04
CPCG01N35/0098G01N35/04G01N2035/00495G01N2035/046
Inventor 樊嘉周俭杨欣荣孙云帆
Owner ZHONGSHAN HOSPITAL FUDAN UNIV